A hypermorphic Nfkbid allele represents an Idd7 locus gene contributing to impaired thymic deletion of autoreactive diabetogenic CD8⁺ T-cells in NOD mice

Abstract

25In both NOD mice and humans the development of type 1 diabetes (T1D) is dependent at 26 least in part on autoreactive CD8 + T-cells recognizing pancreatic ß-cell peptides presented by 27 often quite common MHC class I variants. Studies in NOD mice previously revealed the 28