A hypoxia-irrelevant Fe-doped multivalent manganese oxide sonosensitizer via a vacancy engineering strategy for enhanced sonodynamic therapy

Sun, Lirong; Cao, Yi; Lu, Zhongzhong; Ding, Pi; Wang, Zhili; Ma, Fanshu; Wang, Zheng; Pei, Renjun

doi:10.1016/j.nantod.2022.101434

Cited by 37 publications

(26 citation statements)

References 47 publications

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“…Like type II PDT, the treatment of SDT also requires oxygen as a raw material to produce 1 O 2 . 195 Therefore, dealing with anaerobic TME of cancer cells is a challenge to improve the efficiency of SDT treatment.…”

Section: Targeted Applications Of Porphyrin-based Mofsmentioning

confidence: 99%

Research development of porphyrin-based metal–organic frameworks: targeting modalities and cancer therapeutic applications

Xiang¹,

Zhao²,

Sun³

et al. 2023

J. Mater. Chem. B

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Section: Targeted Applications Of Porphyrin-based Mofsmentioning

confidence: 99%

Research development of porphyrin-based metal–organic frameworks: targeting modalities and cancer therapeutic applications

Xiang¹,

Zhao²,

Sun³

et al. 2023

J. Mater. Chem. B

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“…Their luminescence is stable against photobleaching and has a large Stokes-shift. Those advantages have largely expanded their application towards bioanalytical − and biomedical fields. − The importance of emissive properties of Au NCs has driven related studies of protein-templated Au NCs to focus on the acquisition of the “brightest” Au NCs for a long time . However, the pursuit of the most emissive Au NCs can also result in the so-called “flash blindness effect”, which might limit our knowledge of other potential types of Au NCs, with alternative structural and photophysical properties.…”

Section: Introductionmentioning

confidence: 99%

Protein-Directed Au(0)-Rich Gold Nanoclusters as Ratiometric Luminescence Sensors for Auric Ions via Comproportionation-Induced Emission Enhancement

et al. 2023

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Gold nanoclusters (Au NCs) are widely used as fluorescent probes in biomedical sensing and imaging due to their versatile optical properties and low cytotoxicity. Surface engineering of gold nanoclusters (Au NCs) aims to design a surface with versatile physicochemical performances, but previous investigations have primarily focused on the acquisition of the "brightest" species. This has resulted in other types of Au NC being neglected.In the present study, our group prepared a series of Au NCs that were rich in surface Au(0), using the "aged" form of bovine serum albumin (BSA) via controlling the pH during synthesis. We found that slight increases of alkalinity during synthesis over that which produced Au NCs with the most intensive photoluminescence generated the "darkest" Au NCs, which exhibited the strongest absorption. These Au NCs included more Au atoms and had a higher Au(0) content. Furthermore, the addition of Au 3+ quenched the emission of the "brightest" Au NCs, but increased that of the "darkest" Au NCs. The increased Au(I) proportion observed in the Au 3+ -treated "darkest" Au NCs resulted in a novel comproportionation-induced emission enhancement effect, which we utilized to construct a "turn-on" ratiometric sensor for toxic Au 3+ . The addition of Au 3+ generated simultaneous, opposite effects on blue-emissive diTyr BSA residues and red-emissive Au NCs. After optimization, we successfully constructed ratiometric sensors for Au 3+ with high sensitivity, selectivity, and accuracy. This study will inspire a new pathway to redesign the protein-framed Au NCs and analytical methodology via comproportionation chemistry.

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“…It is found that SDT is similar to photocatalytic oxidation, and the difference is just irradiation conditions. Inspired from photocatalysis, sonosensitizers with narrow band gaps are considered as candidates to increase the number of generated charges. , Besides the construction of heterostructures, the addition of scavengers is also an effective approach to inhibit electron–hole recombination to enhance catalytic performance. Considering the complexity of the tumor microenvironment (TME), it is more likely to use some intracellular constituents as scavengers, such as endogenous glutathione (GSH), to decrease the risk of side effects from other additives.…”

Section: Introductionmentioning

confidence: 99%

Hollow CoP@N–Carbon Nanospheres: Heterostructure and Glucose-Enhanced Charge Separation for Sonodynamic/Starvation Therapy

Wang

Song

Choi³

et al. 2023

ACS Appl. Mater. Interfaces

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Sonodynamic therapy (SDT) can be described as ultrasonic (US) catalysis. Adequate charge separation is considered as effective means to promote reactive oxygen species (ROS). Here, hollow CoP@N–carbon@PEG (CPCs@PEG) nanospheres (∼60 nm) are prepared as sonosensitizers, showing greater ROS generation than pure CoP@PEG under US irradiation. Both 1O2 and ·O2 – are activation species that are determined by O2 and electrons. The great SDT performance of CPCs@PEG is ascribed to the heterostructure which promotes the separation and transfer for US-generated electrons and holes. In addition, holes can be further captured by endogenous glucose that is in favor of electron aggregation and ROS generation. Moreover, the consumption of glucose would decrease intracellular ATP for starvation therapy. Given the higher oxidation ability of Co3+, CPCs@PEG nanospheres possess catalase (CAT) activity to convert H2O2 into O2 for assisting ROS generation. Moreover, they also can oxidize glutathione (GSH) as a mimic GSH oxidase to break intratumor redox balance, facilitating oxidative stress. More importantly, the nanocomposites reveal good degradation ability dominated by the oxidation from insoluble phosphide into soluble phosphate, accelerating elimination via urine and feces within 14 days. CPCs@PEG nanospheres integrate the above effects not only to reveal great tumor inhibition ability but also to excite immune activation for anticancer.

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A hypoxia-irrelevant Fe-doped multivalent manganese oxide sonosensitizer via a vacancy engineering strategy for enhanced sonodynamic therapy

Cited by 37 publications

References 47 publications

Research development of porphyrin-based metal–organic frameworks: targeting modalities and cancer therapeutic applications

Research development of porphyrin-based metal–organic frameworks: targeting modalities and cancer therapeutic applications

Protein-Directed Au(0)-Rich Gold Nanoclusters as Ratiometric Luminescence Sensors for Auric Ions via Comproportionation-Induced Emission Enhancement

Hollow CoP@N–Carbon Nanospheres: Heterostructure and Glucose-Enhanced Charge Separation for Sonodynamic/Starvation Therapy

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