A Jaundiced Eye

Amory, John K.; Rosen, Henry; Sukut, Chadd; Wallace, Findlay; Saint, Sanjay

doi:10.1056/nejmcps053283

Cited by 7 publications

(1 citation statement)

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“…In immunocompromized patients, especially transplant recipients and those infected with HIV, CMV can cause substantial rate of complications and death [1][2][3]. Recently, a case of severe multisystem CMV disorder in a previously healthy host has been described [5]. However, in that case, the patient did not have splenectomy, lymphocytosis, and retinitis, and did not have massive hepatic lymphocyte infiltration.…”

Section: Discussionmentioning

confidence: 99%

Reactivation versus Primary CMV Infection after Splenectomy in Immunocompetent Patients

et al. 2007

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Acute CMV infection in the immunocompetent host is usually asymptomatic or produces only mild symptoms. CMV infection in immunocompromized patients, especially transplant recipients and those infected with HIV, is a result of profound lymphopenia or dysfunction of CD4+/CD8+ cells and can cause substantial rates of complication and death. We present a case of CMV infection in a previously healthy man who just had splenectomy for blunt trauma: a short incubation of the CMV disease, a strongly positive CMV antigenemia, severity of the disease including prominent lymphocytosis, massive hepatic sinusoidal infiltration, and retinitis. Splenectomy changed the immunological defense against the virus and brought the infection to nearly fulminant scale.

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Section: Discussionmentioning

confidence: 99%