A journey from brain to muscle across the thyroid continent

Benvenga, Salvatore

doi:10.1007/s11154-017-9412-5

Cited by 2 publications

(3 citation statements)

References 16 publications

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“…57,58 Muscle-brain crosstalk has been confirmed, especially for exercise-induced myokines. 98,99 Myokines, including FNDC5, cathepsin B, and IL-6 mediate the exercise-induced beneficial impact on neurogenesis. 99 Brain-derived neurotrophic factor (BDNF) is secreted mainly by the brain, 59 and exercise has been shown to also induce the release of BDNF from skeletal muscle.…”

Section: Hepatokinesmentioning

confidence: 99%

“…Mice with a recessive mutation in the leptin receptor gene exhibited defective muscle regeneration, which was attributed to the perturbation of cell cycle reentry of SCs 57,58 . Muscle‐brain crosstalk has been confirmed, especially for exercise‐induced myokines 98,99 . Myokines, including FNDC5, cathepsin B, and IL‐6 mediate the exercise‐induced beneficial impact on neurogenesis 99 .…”

Section: Exercise Regulates Satellite Cell Fate Decisionsmentioning

confidence: 99%

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Control of muscle satellite cell function by specific exercise‐induced cytokines and their applications in muscle maintenance

Guo,

Luo,

Song

2024

J cachexia sarcopenia muscle

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Exercise is recognized to play an observable role in improving human health, especially in promoting muscle hypertrophy and intervening in muscle mass loss‐related diseases, including sarcopenia. Recent rapid advances have demonstrated that exercise induces the release of abundant cytokines from several tissues (e.g., liver, muscle, and adipose tissue), and multiple cytokines improve the functions or expand the numbers of adult stem cells, providing candidate cytokines for alleviating a wide range of diseases. Muscle satellite cells (SCs) are a population of muscle stem cells that are mitotically quiescent but exit from the dormancy state to become activated in response to physical stimuli, after which SCs undergo asymmetric divisions to generate new SCs (stem cell pool maintenance) and commit to later differentiation into myocytes (skeletal muscle replenishment). SCs are essential for the postnatal growth, maintenance, and regeneration of skeletal muscle. Emerging evidence reveals that exercise regulates muscle function largely via the exercise‐induced cytokines that govern SC potential, but this phenomenon is complicated and confusing. This review provides a comprehensive integrative overview of the identified exercise‐induced cytokines and the roles of these cytokines in SC function, providing a more complete picture regarding the mechanism of SC homeostasis and rejuvenation therapies for skeletal muscle.

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Section: Hepatokinesmentioning

confidence: 99%

Section: Exercise Regulates Satellite Cell Fate Decisionsmentioning

confidence: 99%

Control of muscle satellite cell function by specific exercise‐induced cytokines and their applications in muscle maintenance

Guo,

Luo,

Song

2024

J cachexia sarcopenia muscle

View full text Add to dashboard Cite

show abstract

“…Patients with non small-cell lung carcinoma, renal cell carcinoma, and metastatic melanoma treated with nivolumab or pembrolizumab who had baseline antithyroidal antibodies checked before anti-programmed cell death protein-1 (PD1) infusion therapy, and whose antithyroidal antibody concentrations increased and who acquired overt thyroid dysfunction during treatment had higher overall survival [34]. Thyroid dysfunction induced by checkpoint inhibitors has recently been reviewed along with other articles in the thyroid field including environmental aspects and cancer [35][36][37][38][39].…”

Section: The Various Faces Of Hyperthyroidismmentioning

confidence: 99%