A-kinase anchoring protein 13 interacts with the vitamin D receptor to alter vitamin D-dependent gene activation in uterine leiomyoma cells

Cross, Chantel I.; Driggers, Paul H.; McCarthy, Breanne E.; Diab, Maya; Brennan, Joshua T.; Segars, James H.

doi:10.1016/j.xfss.2021.04.002

Cited by 3 publications

(2 citation statements)

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“…A-kinase anchoring protein 13 (AKAP13) interacts with the VDR to alter vitamin D-dependent signaling in UF cells. AKAP13 inhibited the VDR activation by a mechanism that required, at least in part, RhoA activation [117]. In relation to the origin of UFs, specific genetic variations and polymorphisms have been linked to the VDR gene, which could conceivably function as mitigating factors lowering the risk of UFs development [118,119].…”

Section: Vitamin D Serum Level Checkup and Proper Supplementationmentioning

confidence: 99%

“…Supplementation with vitamin D may help alleviate symptoms by modulating hormonal pathways, reducing inflammation, and influencing the growth of UF tissue. It is important to consult with a healthcare professional for personalized advice on incorporating vitamin D as part of a comprehensive treatment approach for managing UF symptoms [117,128].…”

Section: Vitamin D Serum Level Checkup and Proper Supplementationmentioning

confidence: 99%

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Evidence-Based Approach for Secondary Prevention of Uterine Fibroids (The ESCAPE Approach)

Vafaei,

Ciebiera,

Omran

et al. 2023

IJMS

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Uterine fibroids (UFs) are common tumors in women of reproductive age. It is imperative to comprehend UFs’ associated risk factors to facilitate early detection and prevention. Simple relying on surgical/pharmacological treatment of advanced disease is not only highly expensive, but it also deprives patients of good quality of life (QOL). Unfortunately, even if the disease is discovered early, no medical intervention is traditionally initiated until the disease burden becomes high, and only then is surgical intervention performed. Furthermore, after myomectomy, the recurrence rate of UFs is extremely high with the need for additional surgeries and other interventions. This confused approach is invasive and extremely costly with an overall negative impact on women’s health. Secondary prevention is the management of early disease to slow down its progression or even halt it completely. The current approach of watchful observation for early disease is considered a major missed opportunity in the literature. The aim of this article is to present an approach named the ESCAPE (Evidence-Based Approach for Secondary Prevention) of UF management. It comprises simple, inexpensive, and safe steps that can arrest the development of UFs, promote overall reproductive health, decrease the number of unnecessary surgeries, and save billions of health care systems’ dollars worldwide.

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Section: Vitamin D Serum Level Checkup and Proper Supplementationmentioning

confidence: 99%

Section: Vitamin D Serum Level Checkup and Proper Supplementationmentioning

confidence: 99%