A Labdane Diterpene Glucoside from the Rhizomes of Curcuma mangga

Abas, Faridah; Lajis, Nordin H.; Shaari, Khozirah; Israf, Daud Ahmad; Stanslas, Johnson; Yusuf, Umi Kalsom; Raof, Salahuddin Mohd

doi:10.1021/np0500171

Cited by 97 publications

(86 citation statements)

References 22 publications

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“…Phytochemical studies on C. mangga have resulted in the isolation of various compounds, including β-sitosterol, curcumin, (E)-labda-8(17),12-dien-15,16-dial, zerumin A (E)-15,16-bisnorlabda-8(17),11-dien-13-one, demethoxycurcumin and bisdemethoxycurcumin [4,5]. C. mangga has been reported to have analgesic and anti-inflammatory activities [6].…”

Section: Introductionmentioning

confidence: 99%

Acute Toxicity Evaluation of Ethanol Extract of Curcuma Mangga Rhizome

Yuandani

Suwarso

2016

Asian J Pharm Clin Res

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Objective: Curcuma mangga is highly valued in traditional medicines. This study was carried out to evaluate the in vivo acute toxicity of C. mangga.Methods: Acute toxicity of ethanol extract of C. mangga rhizome was evaluated in mice. The extract at a single dose of 500, 1000, 2000 and 5000 mg/kg body weight (BW) were orally administered to the test animal. Signs of toxicity, BW and mortality were observed for 14 days. The macropathology and histopathology examination was also performed. Results:The highest dose administered (5000 mg/kg BW) did not produce mortality of the test animals. Hence, the lethal dose 50 of ethanol extract of C. mangga was estimated to be more than 5000 mg/kg. No sign of toxicity was observed except lethargy. All the organs displayed normal color and texture. Histopathological examination did not show any lesion except for highest dose. Conclusion:The results indicate the safety of ethanol extract of C. mangga rhizome to the animal tested. Therefore, this plant can be used as a safe and effective alternative medicine.

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Section: Introductionmentioning

confidence: 99%

Acute Toxicity Evaluation of Ethanol Extract of Curcuma Mangga Rhizome

Yuandani

Suwarso

2016

Asian J Pharm Clin Res

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“…These include antioxidant, antiarthritic, antimutagenic, antitumor, antithrombotic, antivenom, antibacterial, antifungal, antiviral, nematocidal, choleretic, antihepatotoxic and hemagglutinating activities (Kumar et al 2006;Sangvanich et al 2007). Turmeric also contains a wide variety of phytochemicals (Almedia et al 2005;Abas et al 2005). Due to its growing importance, turmeric is a target crop for gene expression and transcriptome analysis aimed at modifying curcuminoid biosynthetic pathway and identification of transcripts against various human diseases (Annadurai et al 2012).…”

Section: Introductionmentioning

confidence: 99%

A simple and efficient protocol for isolation of high quality functional RNA from different tissues of turmeric (Curcuma longa L.)

Deepa

Sheeja

Santhi

et al. 2014

Physiol Mol Biol Plants

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Many experiments in plant molecular biology require processing of a large number of RNA samples and in some cases large quantities are required for a single application. In turmeric, a major spice and medicinal plant, a protocol for RNA isolation is not available. The major difficulty encountered while using other popular protocols is the low yield and quality of RNA which hampers the downstream applications like qRT-PCR, cDNA synthesis and micro RNA isolation. Commercial kits though available are costly and were found to be unsuccessful in case of rhizomes and root tissues that are rich in polyphenols, polysaccharides and alkaloids. It was thus felt that a quick, handy and cheap protocol of total RNA isolation from different tissues of turmeric was required for day to day working in our lab. The new protocol utilizes SDS based extraction buffer including β-mercaptoethanol and PVP with sequential acid phenol:chloroform extraction to remove polyphenols and proteins, followed by the purification with sodium acetate to eliminate polysaccharides. The protocol is simple and can be completed in less than 3 h. The RNA yield from rhizome was higher by more than fivefold with both A 260/280 and A 260/230 ratio in the range of 1.8-2.0. The protocol worked well with leaf, rhizome, pseudostem and root tissues with RIN >7.0 and the isolated RNA could be successfully used for cDNA synthesis, RT-PCR, qRT-PCR and small RNA isolation including microRNA.

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“…Turmeric Zingiberaceae Root Antioxidant and antitumour [99,100,156] Curcuma mangga Valeton Mango ginger Zingiberaceae Rhizome Antioxidant, antitumour and [157,158] and van Zijp antiallergic Etlingera elatior (Jack)…”

Section: Sesbania Grandifoliamentioning

confidence: 99%

Antioxidant Research in Asia in the Period from 2000-2008

Hafidh¹,

Abdulamir²,

Bakar³

et al. 2009

American J. of Pharmacology and Toxicology

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Problem statement: Plant antioxidants are natural plant products that inhibit the adverse effects of the Reactive Oxygen Species (ROS) produced in plants. Thus, antioxidants enable plants to survive. Depending on this principle, human beings started using some plants' parts to cure from diseases many centuries ago, even before the discovery of microbes or disclosing the etiology of many human diseases. Shed light on the importance of diet and natural products that have proved of great health impact on human traditionally and scientifically, disclosing the central role of natural antioxidants in this matter. Moreover, this review tried to give an overview on the research has so far done in Asian countries particularly in the field of natural antioxidants during the period 2000-2008. Therefore, the aim of this review is to present a comprehensive index for the antioxidant property of herbs and plants that have been traditionally used as well as experimentally proved beneficial in these countries. Approach: We had compared Asian and other nation's diet in the popularity of the traditional medicine and the type of daily meal in respect to their antioxidants contents and valuable health promoting effects. Many literatures had been collected using online search engines and the main library of University Putra Malaysia. The gathered data had been arranged alphabetically in a table depending on the plant's scientific name, common name, the used part(s) and the family name. Results: The research had shown that there were seventy-six plants with proved antioxidant activity which had been well studied by Asian scientists in the chosen period of time. Conclusion: The antioxidant components of the natural products constitute the major source of human health promotion and maintenance. The nature is still the perfect source for health promotion and for the supplementation of safe drugs. Great attention is mandatory from all the scientists around the world to explore many underestimated plants with highly effective antioxidant activity.

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A Labdane Diterpene Glucoside from the Rhizomes of Curcuma mangga

Cited by 97 publications

References 22 publications

Acute Toxicity Evaluation of Ethanol Extract of Curcuma Mangga Rhizome

Acute Toxicity Evaluation of Ethanol Extract of Curcuma Mangga Rhizome

A simple and efficient protocol for isolation of high quality functional RNA from different tissues of turmeric (Curcuma longa L.)

Antioxidant Research in Asia in the Period from 2000-2008

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