A label-free and selective SERS-based sensor for determination of ampicillin contamination in water using a fabric gold–silver alloy substrate with a handheld Raman spectrometer

Abstract

A plasmonic Au–Ag alloy fabric substrate is developed via in situ self-assembly of Au–Ag alloy NPs on muslin fabric. An appropriate molar ratio of Au and Ag and type of substrate are proved to be key factors for selective detection of ampicillin.

Development of a highly sensitive ampicillin sensor utilizing functionalized aptamers

“…Consequently, numerous scholars have focused on developing innovative ampicillin sensors, such as antigen-antibody-based immune sensors, 6 colorimetric, 7 electrochemical, 8,9 fluorescent, 10,11 and Raman sensors based on nucleic acid aptamers. 12–14 Among these, aptamers 15 have been extensively researched for ampicillin detection due to their low cost, high selectivity, and non-toxic side effects. For instance, a turn-off fluorescent aptasensor was developed for the detection of ampicillin, utilizing perylenetetracarboxylic acid diimide (PTCDI) and gold nanoparticles (AuNPs).…”