A label-free electrochemical immunosensor based on the novel signal amplification system of AuPdCu ternary nanoparticles functionalized polymer nanospheres

Yan, Qin; Yang, Yuying; Tan, Zhaoling; Liu, Qing; Liu, Hui; Wang, Ping; Chen, Lei; Zhang, Daopeng; Li, Yueyun; Dong, Yunhui

doi:10.1016/j.bios.2017.12.040

Cited by 69 publications

(22 citation statements)

References 38 publications

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“…They compute the signals generated by the label, leading to versatile and sensitive detection. Nevertheless, the immunosensors can also be label-free, which have the ability to encounter the physical changes during the immuno-complex formation [72,81,82].…”

Section: Electrochemical Sensorsmentioning

confidence: 99%

“…In 2018, another label-free GCE-based immunosensor was designed using a signal amplification system for the detection of hepatitis B surface antigen (HBsAg) [82]. In this work, N-GQDs supported surfactant-free AuPdCu ternary nanoparticles (AuPdCu/N-GQDs) delivered good electroconductivity and excellent catalytic activity for the reduction of H 2 O 2 .…”

Section: Gqd-based Electrochemical Immunosensors For the Detection Ofmentioning

confidence: 99%

“…Schematic representation of a label-free impedimetric electrochemical immunosensor for the recognition of HBV antigen and the preparation procedure of: (A) Polymer nanosphere (PS) functionalized with polyethylenimine (PEI); (B) AuPdCu/N-GQDs@PS. Adapted from[82].…”

mentioning

confidence: 99%

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Graphene Quantum Dot-Based Electrochemical Immunosensors for Biomedical Applications

Mansuriya

Altıntaş

2019

Materials

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In the area of biomedicine, research for designing electrochemical sensors has evolved over the past decade, since it is crucial to selectively quantify biomarkers or pathogens in clinical samples for the efficacious diagnosis and/or treatment of various diseases. To fulfil the demand of rapid, specific, economic, and easy detection of such biomolecules in ultralow amounts, numerous nanomaterials have been explored to effectively enhance the sensitivity, selectivity, and reproducibility of immunosensors. Graphene quantum dots (GQDs) have garnered tremendous attention in immunosensor development, owing to their special attributes such as large surface area, excellent biocompatibility, quantum confinement, edge effects, and abundant sites for chemical modification. Besides these distinct features, GQDs acquire peroxidase (POD)-mimicking electro-catalytic activity, and hence, they can replace horseradish peroxidase (HRP)-based systems to conduct facile, quick, and inexpensive label-free immunoassays. The chief motive of this review article is to summarize and focus on the recent advances in GQD-based electrochemical immunosensors for the early and rapid detection of cancer, cardiovascular disorders, and pathogenic diseases. Moreover, the underlying principles of electrochemical immunosensing techniques are also highlighted. These GQD immunosensors are ubiquitous in biomedical diagnosis and conducive for miniaturization, encouraging low-cost disease diagnostics in developing nations using point-of-care testing (POCT) and similar allusive techniques.

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Section: Electrochemical Sensorsmentioning

confidence: 99%

Section: Gqd-based Electrochemical Immunosensors For the Detection Ofmentioning

confidence: 99%

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Graphene Quantum Dot-Based Electrochemical Immunosensors for Biomedical Applications

Mansuriya

Altıntaş

2019

Materials

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“…[25] Lorentz-Mie theory [26] wasu sed for the theoretical calculation of the plasmonic resonanceo fM NPs. By using Equations (1), (2), (3), (4), and (5), total extinction (Q ext )a nd scattering efficiency (Q sca )f or ah omogenouss pherec an be estimated:…”

Section: Fundamental Properties Of Mnps As Label-free Biosensorsmentioning

confidence: 99%

“…[2] Biological molecules have specific information inscribed by their chemical stimuli, which are captured by the transducer that amplifies andm odifies it into ar eadablef ormat. [3] These devices play ac rucial role in the detection of adrug at aspecific site in the humanbody to regulate the overexpression of disease-causing biomolecules or lysis of invading pathogens.…”

Section: Introductionmentioning

confidence: 99%

Strategies for the Development of Metallic‐Nanoparticle‐Based Label‐Free Biosensors and Their Biomedical Applications

et al. 2019

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Label‐free biosensors offer accurate sensing capabilities due to the reliable quantification of biological and biochemical processes. These devices function by establishing a dynamic interaction of analyte and receptor molecules and convert this interaction into a measurable signal through a transducer. In recent decades, label‐free biosensors have attracted attention in biomedical applications due to the ease of linking nanomaterials with bioreceptor molecules. In this review, recent advances in sensitivity, specificity, and sensing mechanism related to label‐free biosensors of metallic nanoparticles of gold, silver, aluminium, copper, and zinc oxide are presented. Selected sensing methods based on fluorescence, surface plasmon resonance, surface‐enhanced Raman scattering, metal‐enhanced fluorescence, and electrochemical sensors are discussed. New measurement techniques and rapid progress of label‐free biosensors are going to play a vital role in the real‐time detection of biomarkers in clinical samples, such as blood plasma, serum, and urine, as well as in targeted drug delivery. Future trends of these label‐free biosensing mechanisms and their development are also discussed.

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Nanoparticles in Electrochemical Immunosensors – A Concept and Perspective

Polli,

Simonetti,

Surace

et al. 2023

ChemElectroChem

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Nanoparticle‐based electrochemical immunosensors are fascinating and promising screening systems that rely on the affinity binding between antibodies and antigens, allowing the specific detection of diverse types of targets (e. g., proteins, hormones, antibodies). The employment of nanoparticles in the realization of such devices dramatically improves the selectivity, sensitivity, and the transducer surface area for effectively immobilizing the bioreceptor or target molecules. During the last years, the nanoparticles design and fabrication was mainly focused on taking advantage from synergistic effects due to the coupling of different materials. In this review, we summarize the very recent advancements in this regard, with specific emphasis to nanoparticle syntheses procedures, antibody oriented immobilization strategies and transduction techniques. Moreover, the last trends and applications have been extensively discussed along with the remaining challenges and future perspectives.

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A label-free electrochemical immunosensor based on the novel signal amplification system of AuPdCu ternary nanoparticles functionalized polymer nanospheres

Cited by 69 publications

References 38 publications

Graphene Quantum Dot-Based Electrochemical Immunosensors for Biomedical Applications

Graphene Quantum Dot-Based Electrochemical Immunosensors for Biomedical Applications

Strategies for the Development of Metallic‐Nanoparticle‐Based Label‐Free Biosensors and Their Biomedical Applications

Nanoparticles in Electrochemical Immunosensors – A Concept and Perspective

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