A label-free SERS sensor for the detection of Hg2+ based on phenylacetylene functionalized Ag nanoparticles

Zhang, Qijia; Gao, Ce; Ma, Liping; Song, Peng; Xia, Lixin

doi:10.1016/j.microc.2021.106504

Cited by 14 publications

(12 citation statements)

References 42 publications

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“…Matthew’s correlation coefficient of 1 indicated high accuracy in the prediction results. The sensitivity obtained for the 3D brain cancer profiler for label-free detection of brain cancer is higher compared to other label-free noble metal-based nanosensors previously reported. − …”

Section: Resultsmentioning

confidence: 79%

DEEP Surveillance of Brain Cancer Using Self-Functionalized 3D Nanoprobes for Noninvasive Liquid Biopsy

et al. 2022

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Brain cancers, one of the most fatal malignancies, require accurate diagnosis for guided therapeutic intervention. However, conventional methods for brain cancer prognosis (imaging and tissue biopsy) face challenges due to the complex nature and inaccessible anatomy of the brain. Therefore, deep analysis of brain cancer is necessary to (i) detect the presence of a malignant tumor, (ii) identify primary or secondary origin, and (iii) find where the tumor is housed. In order to provide a diagnostic technique with such exhaustive information here, we attempted a liquid biopsy-based deep surveillance of brain cancer using a very minimal amount of blood serum (5 μL) in real time. We hypothesize that holistic analysis of serum can act as a reliable source for deep brain cancer surveillance. To identify minute amounts of tumor-derived material in circulation, we synthesized an ultrasensitive 3D nanosensor, adopted SERS as a diagnostic methodology, and undertook a DEEP neural network-based brain cancer surveillance. Detection of primary and secondary tumor achieved 100% accuracy. Prediction of intracranial tumor location achieved 96% accuracy. This modality of using patient sera for deep surveillance is a promising noninvasive liquid biopsy tool with the potential to complement current brain cancer diagnostic methodologies.

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Section: Resultsmentioning

confidence: 79%

DEEP Surveillance of Brain Cancer Using Self-Functionalized 3D Nanoprobes for Noninvasive Liquid Biopsy

et al. 2022

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“…The new bond formation lowered the peak at 1988 cm –1 and produced a new peak at 2146 cm –1 . This method was successfully used to detect and quantify Hg 2+ in lake water samples several orders of magnitude below the USEPA limits for permissible concentrations in drinking water 99 . A different study proposed a novel SERS aptasensor with dual‐recycling amplification for Hg 2+ detection, combining SERS with nucleic acid signal amplification to obtain a more sensitive detection 86 .…”

Section: Analytes Of Interestmentioning

confidence: 99%

“…This method was successfully used to detect and quantify Hg 2+ in lake water samples several orders of magnitude below the USEPA limits for permissible concentrations in drinking water. 99 A different study proposed a novel SERS aptasensor with dual‐recycling amplification for Hg 2+ detection, combining SERS with nucleic acid signal amplification to obtain a more sensitive detection. 86 Dual‐recycling amplification involves the immobilization of aptamers onto a substrate and bound with a complementary DNA strand, which will cleave off once the target molecule is introduced and is captured by the aptamer.…”

Section: Analytes Of Interestmentioning

confidence: 99%

“…In this review, we will look into articles published in 2021 and 2022 (those accessible as of December 2021), with a special focus on newest findings in SERS nanosubstrate development and applications in analysing different chemical and biological pollutants. Additionally, Table 1 provides an overview of these recent publications involving SERS for environmental contaminant detection and Table 2 Tap and lake water 0.11 Fm [86] IP6@AgNPs probe Fe 3+ Integrated circuit cleaning solution waste 0.1 μM [90] Phenylacetylene-AgNPs Hg 2+ Lake water 87.6 pM [99] Dual enhancement SERS sensor Pb 2+ Water 4.31 pM [42] Gold nanoparticles Polystyrene and poly (ethylene terephthalate)…”

Section: Introductionmentioning

confidence: 99%

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Applications of surface‐enhanced Raman spectroscopy in environmental detection

Terry

Sanders

Potoff

et al. 2022

Analytical Science Advances

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As the human population grows, the anthropogenic impacts from various agricultural and industrial processes produce unwanted contaminants in the environment. The accurate, sensitive and rapid detection of such contaminants is vital for human health and safety. Surface-enhanced Raman spectroscopy (SERS) is a valuable analytical tool with wide applications in environmental contaminant monitoring. The aim of this review is to summarize recent advancements within SERS research as it applies to environmental detection, with a focus on research published or accessible from January 2021 through December 2021 including early-access publications. Our goal is to provide a wide breadth of information that can be used to provide background knowledge of the field, as well as inform and encourage further development of SERS techniques in protecting environmental quality and safety. Specifically, we highlight the characteristics of effective SERS nanosubstrates, and explore methods for the SERS detection of inorganic, organic, and biological contaminants including heavy metals, pharmaceuticals, plastic particles, synthetic dyes, pesticides, viruses, bacteria and mycotoxins. We also discuss the current limitations of SERS technologies in environmental detection and propose several avenues for future investigation. We encourage researchers to fill in the identified gaps so that SERS can be implemented in a real-world environment more effectively and efficiently, ultimately providing reliable and timely data to help and make science-based strategies and policies to protect environmental safety and public health.

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“…At present, the main detection methods of Hg 2+ include fluorescence spectrometry, [3][4][5] atomic absorption/emission spectrometry, [6][7][8] inductively coupled plasma mass spectrometry, [9][10][11] surface-enhanced Raman scattering [12][13][14] and electrochemical sensors [15,16] and so on. Among these methods, electrochemical methods have attracted much attention due to their advantages of low cost, fast response, easy miniaturization of the instrument, and being suitable for field detection.…”

Section: Introductionmentioning

confidence: 99%

Screen‐printed electrode‐based homogeneous electrochemical aptasensor for mercury (II) based on reduced graphene oxide and exonuclease III‐driven cyclic reaction

Zhang

Jin

et al. 2022

J Chinese Chemical Soc

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A novel disposable and portable electrochemical aptasensor based on reduced graphene oxide (RGO) was constructed for the detection of mercury (II) (Hg 2+ ) using methylene blue (MB) as the signal tag and exonuclease III-induced cyclic reaction as signal amplification strategy. RGO was utilized as a carrier to immobilize MB-DNA, and screen-printed electrode (SPE) was used as the substrate electrode. The whole reaction was carried out in a homogeneous system, and finally, the target was detected directly in the solution using SPE, which did not require multiple fixation steps and simplified the experimental process. Under the optimized conditions, the developed electrochemical aptasensor had a wide linear range of 0.01-300 nmol L À1 with a low detection limit of 0.009 nmol L À1 and was successfully used for the determination of Hg 2+ in tap water samples. Furthermore, the aptasensor exhibited good stability and high selectivity. It had good application prospects in the detection of harmful substances in food.

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A label-free SERS sensor for the detection of Hg2+ based on phenylacetylene functionalized Ag nanoparticles

Cited by 14 publications

References 42 publications

DEEP Surveillance of Brain Cancer Using Self-Functionalized 3D Nanoprobes for Noninvasive Liquid Biopsy

DEEP Surveillance of Brain Cancer Using Self-Functionalized 3D Nanoprobes for Noninvasive Liquid Biopsy

Applications of surface‐enhanced Raman spectroscopy in environmental detection

Screen‐printed electrode‐based homogeneous electrochemical aptasensor for mercury (II) based on reduced graphene oxide and exonuclease III‐driven cyclic reaction

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