A laboratory-based study on patients with Parkinson’s disease and seborrheic dermatitis: the presence and density of Malassezia yeasts, their different species and enzymes production

Arsenijevic, Valentina S Arsic; Milobratović, Danica; Barać, Aleksandra; Vekić, Berislav; Marinković, Jelena; Kostić, Vladimir

doi:10.1186/1471-5945-14-5

Cited by 71 publications

(78 citation statements)

References 28 publications

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“…Within the elderly population, SD has been associated with localized itch [61,62]. SD is a particularly common skin manifestation in elderly patients with Parkinson's disease, depression or anxiety [63,64].…”

Section: Cutaneous Conditionsmentioning

confidence: 99%

Chronic Pruritus in the Elderly: Pathophysiology, Diagnosis and Management

2015

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Chronic itch in the elderly is a common problem, with a significant impact on quality of life and sleep in elderly patients. Chronic itch may be attributable to several causes, including dry skin, immunosenescence and neural degeneration. Itch may also be caused by skin diseases, such as seborrhoeic dermatitis and stasis dermatitis; systemic conditions, such as end-stage renal disease and diabetes; and psychogenic conditions, such as depression and anxiety. The use of polypharmacy may also cause itch, with or without a rash. Specifically, thiazides and calcium channel blockers have been known to cause itch in elderly patients. Management should be tailored according to the underlying dermatological or systemic aetiology of itch. Topical treatment is the mainstay of therapy, providing special emphasis on skin hydration and barrier repair. In addition, topical and oral medications that target the nervous system and reduce neuronal hypersensitization, such as gabapentin and selective antidepressants, have a role in treating patients with severe chronic itch. Furthermore, management must account for changes in metabolism and pharmacokinetics of drugs in the aging population in order to prevent the occurrence of adverse effects.

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Section: Cutaneous Conditionsmentioning

confidence: 99%

Chronic Pruritus in the Elderly: Pathophysiology, Diagnosis and Management

2015

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“…The increased production of host sebum as well as the presence and increased reproduction of Malassezia yeasts are the two major factors believed to contribute to the development of SD 4,8. Seborrhea has been associated with PD, with a prevalence as high as 52%–59% 8.…”

Section: Skin Conditions In Pdmentioning

confidence: 99%

“…Seborrhea has been associated with PD, with a prevalence as high as 52%–59% 8. In 1927, Krestin reported seborrheic facies as a cutaneous manifestation of parkinsonism, particularly in post-encephalic parkinsonism,9 and described the skin as shiny, greasy, and with characteristic scarring acne.…”

Section: Skin Conditions In Pdmentioning

confidence: 99%

Skin disorders in Parkinson’s disease: potential biomarkers and risk factors

Ravn¹,

Thyssen²,

Egeberg³

2017

CCID

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Parkinson’s disease (PD) is one of the most common neurodegenerative disorders, characterized by a symptom triad comprising resting tremor, rigidity, and akinesia. In addition, non-motor symptoms of PD are well recognized and often precede the overt motor manifestations. Cutaneous manifestations as markers of PD have long been discussed, and cumulative evidence shows an increased prevalence of certain dermatological disorders in PD. Seborrheic dermatitis is considered to occur as a premotor feature of PD referable to dysregulation of the autonomic nervous system. Also, an increased risk of melanoma has been observed in PD. Light hair color is a known risk factor for melanoma, and interestingly the risk of PD is found to be significantly higher in individuals with light hair color and particularly with red hair. Furthermore, several studies have reported a high prevalence of PD in patients with bullous pemphigoid. Moreover, a 2-fold increase in risk of new-onset PD has been observed in patients with rosacea. Besides the association between PD and various dermatological disorders, the skin may be useful in the diagnosis of PD. Early PD pathology is found not only in the brain but also in extra-neuronal tissues. Thus, the protein α-synuclein, which is genetically associated with PD, is present not only in the CNS but also in the skin. Hence, higher values of α-synuclein have been observed in the skin of patients with PD. Furthermore, an increased risk of PD has been found in the Cys/Cys genotype, which is associated with red hair color. In this review, we summarize the current evidence of the association between PD and dermatological disorders, the cutaneous adverse effects of neurological medications, and describe the potential of skin protein expression and biomarkers in identification of risk and diagnosis of PD.

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“…3 Parkinson hastalarının derilerinde artmış sebum salgısı olur. 32 Down sendromu ve Hailey-Hailey hastalığı gibi bazı genetik hastalıklarda da SD daha sıktır. 33,34 SD'nin etiyopatogenezde rol oynadığı düşünü-len faktörler Tablo 1'de görülmektedir.…”

Section: Hormonal Faktörlerunclassified

Seborrheic Dermatitis: Review

Aksoy¹,

ARICA²

2016

Turkiye Klinikleri J Dermatol

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deri gibi sebase bezlerden zengin alanlarda yerleşir. Özellikle adolesan ve postadolesan yaş grubunu etkileyen SD, genel populasyonda %3-5, gençlerde %1-3 oranında görülür. İmmün yetmezlikli hastalarda daha yüksek oranlarda görülen SD, infantil başlangıçlı SD ve erişkin başlangıçlı SD olarak iki gruba ayrılabilir. Nedeni tam olarak bilinmeyen, etiyolojisinde birçok faktörün rol oynadığı multifaktöriyel bir hastalıktır. Bu faktörler stres, androjenler, depresyon, yorgunluk, mikroanjiyopatik olabilen vasküler bozukluklar, basınç değişiklikleri gibi atmosfer değişiklikleri, mevsimler, giyim, beslenme biçimleri ve yiyecek allerjileri, otoimmünite, klimakterik değişiklikler, Malassezia furfur, başka nedenlerle alınan ilaçlar, riboflavin, piridoksin, biyotin eksiklikleri gibi birçok faktördür. Seboreik dermatit lezyonlarının histopatolojisi, psöriyazis ve spongiyotik dermatitin histopatolojik bulgularının kombinasyonu şeklindedir. Klinik olarak ayırıcı tanısı ise tutulan lokalizasyona göre değişiklik göstermesidir. Hastalığın şiddetine, morfolojik değişikliklere ve önceki tedavilere verilen yanıta göre seçilen tedavi, daha çok alevlenmeleri kontrol altına almaya yöneliktir. Antifungaller, retinoidler, kortikosteroidler ve fototerapi, bu amaçla kullanılan sistemik tedavi seçenekleridir. Aynı amaç için kullanılan topikal tedavi seçenekleri çok çeşitli olup, salisilik asit, kömür katranı, ardıç katranı, selenyum sülfit, çinko piritiyon gibi keratolitik ajanlar; azoller, alilaminler, benzilaminler, hidroksipiridonlar gibi antifungaller; takrolimus ve pimekrolimus gibi immünmodülatörler; kepek şampuanı, antifungal ajanlar ve topikal steroidleri içeren kombine tedaviler; lityum süksinat, lityum glukonat gibi lityum bileşikleri; kortikosteroidler; metronidazol; 1-24 dihidroksikalsiferol; çay ağacı yağı; 'borage' yağı; aloe vera ekstresi; propilen glikol gibi birçok seçeneği içerir. Bu çalışma, SD etiyopatogenezi, kliniği ve tedavisi ile bu alanda mevcut güncel literatürleri içermektedir.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Dermatit,seboreik; etiyoloji; tedavi; tanı A AB BS S T TR RA AC CT T Seborrheic dermatitis is a chronic relapsing inflammatory skin disorder clinically characterized by scaling and poorly defined erythematous patches. Seborrheic dermatitis has a distinctive distribution in areas rich in sebaceous glands -the scalp, eyebrows, glabella, nasolabial and nasofacial folds, cheeks, peri-auricular skin, presternal and interscapular areas. SD especially affecting adolescence and postadolescence is seen in both general and young population with ratios 3-5%, 1-3%, respectively. Seborrheic dermatitis seen at higher rates in patients immunocompromised, can be divided into infantile-onset SD and adult-onset SD. Seborrheic dermatitis is a multifactorial disease that many factors play a role in it's ethiology, although the reason of SD is exactly unknown. These factors are stress, androgens, depression, fatigue, vascular disorder which can be microangiopathic, athmosphere changes such as pressure alter...

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A laboratory-based study on patients with Parkinson’s disease and seborrheic dermatitis: the presence and density of Malassezia yeasts, their different species and enzymes production

Cited by 71 publications

References 28 publications

Chronic Pruritus in the Elderly: Pathophysiology, Diagnosis and Management

Chronic Pruritus in the Elderly: Pathophysiology, Diagnosis and Management

Skin disorders in Parkinson’s disease: potential biomarkers and risk factors

Seborrheic Dermatitis: Review

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A laboratory-based study on patients with Parkinson’s disease and seborrheic dermatitis: the presence and density of Malassezia yeasts, their different species and enzymes production

Cited by 71 publications

References 28 publications

Chronic Pruritus in the Elderly: Pathophysiology, Diagnosis and Management

Chronic Pruritus in the Elderly: Pathophysiology, Diagnosis and Management

Skin disorders in Parkinson&rsquo;s disease: potential biomarkers and risk factors

Seborrheic Dermatitis: Review

Contact Info

Product

Resources

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Skin disorders in Parkinson’s disease: potential biomarkers and risk factors