A large pigmented lesion mimicking malignant melanoma

Clinical and dermoscopic features of genital pigmented Bowen disease

“…Similarly, the precise mechanism of pigmentation of pBD has not yet been completely clarified. It has been suggested that neoplastic cells may produce specific factors or cytokines, promoting the proliferation of melanocytes with subsequent synthesis and secretion of melanin . An alternative hypothesis suggests that in the anogenital area, pigmentation in BD might be secondary to increased temperature or simply due to the physiological hyperpigmentation in this region .…”

“…There are several treatment options for BD, including surgery, topical agents (such as 5‐fluorouracil or imiquimod), curettage, laser ablation, electrocauterization, radiotherapy and photodynamic therapy . The prognosis or treatment of BD does not depend on the presence of pigmentation, but on tumour characteristics such as site, size and number of lesions and patient‐related factors such as age, immunological status and comorbidities…”