A large-scale transcriptional study reveals inhibition of COVID-19 related cytokine storm by traditional Chinese medicines

Dai, Yifei; Qiang, Weijie; Gui, Yu; Tan, Xiaojun; Pei, Tianli; Lin, Kequan; Cai, Siwei; Sun, Liang; Ning, Guochen; Wang, Jianxun; Guo, Hongyan; Sun, Yimin; Cheng, Jing; Xie, Liang; Lan, Xun; Wang, Dong

doi:10.1016/j.scib.2021.01.005

Cited by 28 publications

(22 citation statements)

References 16 publications

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“…The HTS 2 assay mainly comprised cell culture, treatment with herb extracts, probe design, and screening. In this research, HTS 2 assay was carried out to detect the regulation of six herbal extracts in TSD on a total of 2336 genes in MDA-MB-231 cells, which was in accordance with our previous report [10] , [11] .…”

Section: Methodssupporting

confidence: 83%

“…It can be used to quantitatively analyze gene matrices related to a specific pathway to screen out potential drugs [9] . Moreover, it can be applied in large-scale herb treated cell gene studies that offer novel perspectives in research into TCM [10] , [11] . In comparison with conventional screening strategies, HTS 2 has several advantages, namely, cost-effectiveness, time-savings, and higher reproducibility [12] .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Taohong Siwu Decoction exerts anticancer effects on breast cancer via regulating MYC, BIRC5, EGF and PIK3R1 revealed by HTS2 technology

Gui

Dai²,

Wang³

et al. 2022

Computational and Structural Biotechnology Journal

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Section: Methodssupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Taohong Siwu Decoction exerts anticancer effects on breast cancer via regulating MYC, BIRC5, EGF and PIK3R1 revealed by HTS2 technology

Gui

Dai²,

Wang³

et al. 2022

Computational and Structural Biotechnology Journal

Self Cite

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“…Yang et al 375 showed that Qingfei Paidu Decoction, one of the most well-known anti-COVID-19 formulae, can defend against COVID-19 by regulating multiple CS-related signaling pathways such as the NF-κB and MAPK pathways and cytokines such as TNF-α, IL-1β, and IL-8. In addition, Dai et al 376 conducted a large-scale transcriptional study to evaluate the effects of 578 herbs and all 338 reported anti-COVID-19 TCM formulae on CS-related signaling, by combining high-throughput sequencing-based screening assay with bioinformatics and computer-aided drug design. The results showed that some herbs might inhibit the IL-6 pathway, some, the TNF-α pathway, and some drugs such as Guizhi and Qingfei Paidu Decoction may inhibit both pathways.…”

Section: Interventions Targeting Multiple Cytokines and Pathwaysmentioning

confidence: 99%

The signal pathways and treatment of cytokine storm in COVID-19

Yang

Xie

et al. 2021

Sig Transduct Target Ther

466

413

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The Coronavirus Disease 2019 (COVID-19) pandemic has become a global crisis and is more devastating than any other previous infectious disease. It has affected a significant proportion of the global population both physically and mentally, and destroyed businesses and societies. Current evidence suggested that immunopathology may be responsible for COVID-19 pathogenesis, including lymphopenia, neutrophilia, dysregulation of monocytes and macrophages, reduced or delayed type I interferon (IFN-I) response, antibody-dependent enhancement, and especially, cytokine storm (CS). The CS is characterized by hyperproduction of an array of pro-inflammatory cytokines and is closely associated with poor prognosis. These excessively secreted pro-inflammatory cytokines initiate different inflammatory signaling pathways via their receptors on immune and tissue cells, resulting in complicated medical symptoms including fever, capillary leak syndrome, disseminated intravascular coagulation, acute respiratory distress syndrome, and multiorgan failure, ultimately leading to death in the most severe cases. Therefore, it is clinically important to understand the initiation and signaling pathways of CS to develop more effective treatment strategies for COVID-19. Herein, we discuss the latest developments in the immunopathological characteristics of COVID-19 and focus on CS including the current research status of the different cytokines involved. We also discuss the induction, function, downstream signaling, and existing and potential interventions for targeting these cytokines or related signal pathways. We believe that a comprehensive understanding of CS in COVID-19 will help to develop better strategies to effectively control immunopathology in this disease and other infectious and inflammatory diseases.

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“…In Covid-19, IKBKAP gene is downregulated due to inflammatory changes, and Zexie herbal medicine ameliorates COVID-19-complications mainly DSN through upregulation of IKBKAP gene (Dai et al, 2021). Similarly, N-type calcium channels are upregulated in SARS-CoV-2 infection leading to autonomic dysfunction and cardiac conductive abnormality.…”

Section: Molecular Mechanism Of Dysautonomia In Covid-19mentioning

confidence: 99%

Covid-19-Induced Dysautonomia: A Menace of Sympathetic Storm

Al-Kuraishy¹,

Al-Gareeb²,

Qusti

et al. 2021

ASN Neuro

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Among the plethora of debilitating neurological disorders of COVID-19 syndrome in survivors, the scope of SARS-CoV-2-induced dysautonomia (DNS) is yet to be understood, though the implications are enormous. Herein, we present an inclusive mini-review of SARS-CoV-2-induced DNS and its associated complications. Although, the direct link between Covid-19 and DSN is still speculative, the hypothetical links are thought to be either a direct neuronal injury of the autonomic pathway or a para/post-infectious immune-induced mechanism. SARS-CoV-2 infection-induced stress may activate the sympathetic nervous system (SNS) leading to neuro-hormonal stimulation and activation of pro-inflammatory cytokines with further development of sympathetic storm. Sympathetic over-activation in Covid-19 is correlated with increase in capillary pulmonary leakage, alveolar damage, and development of acute respiratory distress syndrome. Furthermore, SARS-CoV-2 can spread through pulmonary mechanoreceptors and chemoreceptors to medullary respiratory center in a retrograde manner resulting in sudden respiratory failure. Taken together, DSN in Covid-19 is developed due to sympathetic storm and inhibition of Parasympathetic nervous system-mediated anti-inflammatory effect with development of cytokine storm. Therefore, sympathetic and cytokine storms together with activation of Renin-Angiotensin-System are the chief final pathway involved in the development of DSN in Covid-19.

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A large-scale transcriptional study reveals inhibition of COVID-19 related cytokine storm by traditional Chinese medicines

Cited by 28 publications

References 16 publications

Taohong Siwu Decoction exerts anticancer effects on breast cancer via regulating MYC, BIRC5, EGF and PIK3R1 revealed by HTS2 technology

Taohong Siwu Decoction exerts anticancer effects on breast cancer via regulating MYC, BIRC5, EGF and PIK3R1 revealed by HTS2 technology

The signal pathways and treatment of cytokine storm in COVID-19

Covid-19-Induced Dysautonomia: A Menace of Sympathetic Storm

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