A Lectin Immunosensor Technique for Determination of α1-Acid Glycoprotein Fucosylation

Mucoadhesive Microspheres for Controlled Drug Delivery

“…24) They may be used to target therapeutic agents for different gut components or even for different cells (e.g. complex-specific lectins for parietal cells or fucose-specific Galanthus nivalis agglutinin (GNA) Epithelial cells in stomach, caecum, and colon 2 N-Acetyl Wheat germ agglutinin (WGA) Epithelial cells in stomach, caecum, colon and absorptive glucosamine 57) enterocytes in small intestine Lycopersicon esculentum or tomato Strong binding to M cells lectin (LEA) 3 N-Acetyl Lectin ML-1 from Visum album Endocytosed by villus enterocytes and goblet cells strong glucosamine 58) binding to epithelial cells in small intestine 4 P h ytohaemagglutinin 59) Phaseolus vulgaris isoagglutinin Surface cells of the stomach 5 Fucose 60) Aleuria aurentia agglutinin (AAA) Specific binding and transcytosis by M cells lectins for M cells). A bioinvasive mechanism has been described for the activity of lectins as targeting moieties.…”

Surface plasmon resonance immunosensor for human cardiac troponin T based on self-assembled monolayer

“…Due to SPR does not require label or tracer reducing the number of steps, permitting real-time analysis of interactions, regeneration of the sensor surfaces and low cost analysis, etc. innumerous SPR systems were developed including the commercial BIAcore system [16][17][18][19]. Although, the BIAcore system has dominated the market since their introduction, a number of SPR instruments more sensitive have been recently introduced.…”

X-ray crystallographic characterization and phasing of a fucose-specific lectin fromAleuria aurantia

“…Because AAL exhibits a higher af®nity toward fucosylated sugars than the other two types of fucose-speci®c lectin, it has commonly been used as a speci®c probe for fucosecontaining oligosaccharides (Liljeblad et al, 2001;Ohkura et al, 1994). This lectin was isolated from the fruiting bodies of an orangepeel mushroom, A. aurantia, and is known to exist as a dimer under physiological conditions (Kochibe & Furukawa, 1980).…”