A Leishmania infantum enzymatic variant, causative agent of cutaneous leishmaniasis in north Tunisia

Gramiccia, Marina; Ben-Ismail, R.; Gradoni, Luigi; Rachid, Mohamed; Saïd, M. Ben

doi:10.1016/0035-9203(91)90294-9

Cited by 40 publications

(19 citation statements)

References 10 publications

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“…documented LICL in 6 publications 12,13,16,18,22,23 and the initial reports by Rioux and colleagues, 2,10,11 providing at least clinical, biological, histological, or therapeutic information.…”

Section: Methodsmentioning

confidence: 99%

“…The most usual clinical feature is a single lesion that consists of small, crusty ulcers surrounded by a notable erythematous reaction or nonulcerated papules that, when ulcerated, are recovered with a discrete crust. 30 Lesions are located on the face (80%), are generally unique or few in number (1-3), 16,23 and are symptomless. The medium diameter is 10 mm, but it varies from a few to 30 mL.…”

Section: Clinical Featuresmentioning

confidence: 99%

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Cutaneous Leishmaniasis Due to Leishmania infantum

Giudice¹,

Marty²,

Lacour³

et al. 1998

Arch Dermatol

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Background: Leishmania infantum recently has been identified as a possible agent of cutaneous leishmaniasis (CL). This species has been isolated from cutaneous lesions of patients from the Mediterranean Basin. However, little is known about the clinical, biological, or therapeutic features of this newly recognized CL.Observations: Six patients aged 9 months to 85 years in southeastern France were found to have autochthonous leishmaniasis. Parasitological identification showed that the agent was L infantum, zymodemes Montpellier-1 for 2 patients and Montpellier-24 for 1 patient. Five patients who underwent testing with a Western blot assay were found to have antibodies against 4 antigens with molecular masses of 18, 21, 23, and 31 kd. Five patients were successfully treated with local injections of N-methylglucamine, and 1 patient was successfully treated with topical paromomycin sulfate. No patient had visceral disease at diagnosis or after follow-up.Conclusions: Recent data provide increasing evidence that L infantum is an important agent of CL. In southwestern Europe, this species is the only agent that has long been identified from autochthonous CL. Leishmania infantum should be considered an agent of CL in areas in which visceral leishmaniasis is endemic. Western blot assay could be a useful test for the diagnosis, but precise parasitological identification is important to having a better knowledge of the disease. The relationships between CL and the visceral disease have to be explored.

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Section: Methodsmentioning

confidence: 99%

Section: Clinical Featuresmentioning

confidence: 99%

Cutaneous Leishmaniasis Due to Leishmania infantum

Giudice¹,

Marty²,

Lacour³

et al. 1998

Arch Dermatol

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“…Indeed, all L. major strains obtained from humans, rodents and sandflies proved to be identical to the L. major MON 25 reference strain (Aoun et al, 2008 ;Ben Ismail et al, 1986;Haouas et al, 2007 ;Kallel et al, 2005). In contrast, at least three L. infantum zymodemes occur in Tunisia : i) the MON 1, mainly causing VL and to a lesser extent SCL ; ii) the MON 24, the most common agent of SCL, that also causes VL ; iii) the MON 80, which is very rarely isolated (Aoun et al, 1999(Aoun et al, , 2008Bel Hadj et al, 2000Gramiccia et al, 1991;Haouas et al, 2007). These findings show that a single zymodeme may cause quite different diseases; and raise the as yet poorly documented question of pathogenesis and virulence of strains in cause.…”

Section: Discussionmentioning

confidence: 99%

Retrospective Analysis of Leishmaniasis in Central Tunisia: An Update on Emerging Epidemiological Trends

Mili¹,

Saghrouni²,

BenSaid³

et al. 2012

Current Topics in Tropical Medicine

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“…Zymodeme MON-24 was previously considered to be a dermotropic zymodeme causative of sporadic CL in northern Tunisia (Aoun et al, 2000). In 1991, this zymodeme was isolated for the first time from a child with VL in the North (Gramiccia et al 1991) Belhadj et al, 2002). All cases were reported in the North part of the country including Zaghouan province which has frontier with Kairouan province.…”

Section: Discussionmentioning

confidence: 99%

“…Two zymodemes were reported in this form of leishmaniasis: zymodeme MON-24 was described as a predominant agent of sporadic CL in Seliana province in the North (Bel Hadj et al, 2002a). It is also encountered in neighboring countries such as Algeria and Morocco (Gramiccia et al, 1991;Harrat et al, 1996). However, the zymodeme MON-1 was isolated for the first time in 1999 in the North (Aoun et al, 2000).…”

Section: Human Cutaneous Leishmaniasismentioning

confidence: 99%