A light-controllable specific drug delivery nanoplatform for targeted bimodal imaging-guided photothermal/chemo synergistic cancer therapy

Guo, Yuan; Wang, Xingyue; Chen, Yuli; Liu, Feng-Qiu; Tan, Mixiao; Meng, Aimin; Yu, Jinhong; Ran, Haitao; Wang, Zhao-xia

doi:10.1016/j.actbio.2018.09.024

Cited by 75 publications

(36 citation statements)

References 40 publications

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“…Finally, a carboxyl-modified PEGylated poly skeleton, to which the herceptin antibody was modified to present a HER-2 specific surface, was added to superparamagnetic iron oxide nanoparticles (SPIONs), with perfluorohexane and paclitaxel [95]. These SPIONs were activated by NIR laser and allowed the transformation of laser energy into thermal energy, causing the perfluorohexane to be vaporized and consequently release paclitaxel.…”

Section: Nanotheranostics In Diagnosis and Treatment Of Cancermentioning

confidence: 99%

“…These SPIONs were activated by NIR laser and allowed the transformation of laser energy into thermal energy, causing the perfluorohexane to be vaporized and consequently release paclitaxel. Therefore, this nanotheranostic comprises another combination of photothermal therapy and chemotherapy for the treatment of breast cancer [95].…”

Section: Nanotheranostics In Diagnosis and Treatment Of Cancermentioning

confidence: 99%

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Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems

et al. 2019

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Theranostics has emerged in recent years to provide an efficient and safer alternative in cancer management. This review presents an updated description of nanotheranostic formulations under development for skin cancer (including melanoma), head and neck, thyroid, breast, gynecologic, prostate, and colon cancers, brain-related cancer, and hepatocellular carcinoma. With this focus, we appraised the clinical advantages and drawbacks of metallic, polymeric, and lipid-based nanosystems, such as low invasiveness, low toxicity to the surrounding healthy tissues, high precision, deeper tissue penetration, and dosage adjustment in a real-time setting. Particularly recognizing the increased complexity and multimodality in this area, multifunctional hybrid nanoparticles, comprising different nanomaterials and functionalized with targeting moieties and/or anticancer drugs, present the best characteristics for theranostics. Several examples, focusing on their design, composition, imaging and treatment modalities, and in vitro and in vivo characterization, are detailed herein. Briefly, all studies followed a common trend in the design of these theranostics modalities, such as the use of materials and/or drugs that share both inherent imaging (e.g., contrast agents) and therapeutic properties (e.g., heating or production reactive oxygen species). This rationale allows one to apparently overcome the heterogeneity, complexity, and harsh conditions of tumor microenvironments, leading to the development of successful targeted therapies.

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Section: Nanotheranostics In Diagnosis and Treatment Of Cancermentioning

confidence: 99%

Section: Nanotheranostics In Diagnosis and Treatment Of Cancermentioning

confidence: 99%

Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems

et al. 2019

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“…Dual-modality imaging, which provides non-invasive assessment of preoperative disease and provides real-time fluorescence imaging of tumour margins during surgery, is an important research direction in tumour imaging [64]. Dualmodality imaging results of multiple imaging can be mutually verified, so the imaging results of multimodal imaging are more accurate and reliable than single-modal imaging [65,66]. For example, a dual-labelled bispecific antibody 64 Cu-NOTA-heterodimer-ZW800 was synthesized though biorthogonal click chemistry [67].…”

Section: Antibody Fragment In Dual-modality Imagingmentioning

confidence: 99%

A promising cancer diagnosis and treatment strategy: targeted cancer therapy and imaging based on antibody fragment

Zhao

Ning

Zhang

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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With the arrival of the precision medicine and personalized treatment era, targeted therapy that improves efficacy and reduces side effects has become the mainstream approach of cancer treatment. Antibody fragments that further enhance penetration and retain the most critical antigen-specific binding functions are considered the focus of research targeting cancer imaging and therapy. Thanks to the superior penetration and rapid blood clearance of antibody fragments, antibody fragment-based imaging agents enable efficient and sensitive imaging of tumour sites. In tumour-targeted therapy, antibody fragments can directly inhibit tumour proliferation and growth, serve as an ideal carrier for delivery of anti-tumour drugs, or manipulate the immune system to eliminate tumour cells. In this review, the excellent physicochemical properties and the basic structure of antibody fragments are expressly depicted depicted, the progress of antibody fragments in cancer therapy and imaging are thoroughly summarized, and the future development of antibody fragments is predicted.

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“…35 The quest for synergetic chemo and photothermal therapy also lead to the design of innovative core-shell nanostructures, made of a poly(lacticco-glycolic acid), PLGA, polymer surrounding liquid perfluorohexane and superparamagnetic oxide. The combination of those elements inside a single nanoplatform allowed for the precise monitoring of their location in vivo using bimodal ultrasound/photoacoustic (US/PA) imaging thus helping with the spatiotemporal activation of paclitaxel release and localized hyperthermia leading to severe reduction of mice tumor growth 36 Photothermal agent Ni8C 12 was synthesized according to the method previously described. 18,37 Preparation of the liposomes containing nickel-bis(dithiolene) complexes.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Liposomes Containing Nickel–Bis(dithiolene) Complexes for Photothermal Theranostics

et al. 2019

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New thermosensitive liposomes with a phase transition at 42 °C, containing nickelbis(dithiolene) complexes as efficient and stable photothermal agents, have been formulated and characterized. These liposomes are highly stable and keep their contents at 37 °C for more than 30 days. On the contrary, the mild hyperthermia generated by the nickel-bis(dithiolene) complex under 940 nm NIR irradiation allows for the fine controlled release of the liposome contents, making such liposomes highly suitable for on-demand drug delivery in human body under NIR laser irradiation. These liposomes can also be directly used, as shown here, as nanoagents for photothermal therapy. In fact, strong cell death can be generated under laser irradiation in presence of these photothermally active nanocargos containing less than 10 %w/w

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A light-controllable specific drug delivery nanoplatform for targeted bimodal imaging-guided photothermal/chemo synergistic cancer therapy

Cited by 75 publications

References 40 publications

Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems

Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems

A promising cancer diagnosis and treatment strategy: targeted cancer therapy and imaging based on antibody fragment

Liposomes Containing Nickel–Bis(dithiolene) Complexes for Photothermal Theranostics

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