A link between depression and bone metabolism: what are the implications for treatment?

Mezuk, Briana; Golden, Sherita Hill

doi:10.1586/eem.09.2

Cited by 3 publications

(1 citation statement)

References 45 publications

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“…Antidepressant classes may also confer differential fracture risk (Gagne et al, 2011). Frailty may contribute to withdrawal from pharmacotherapy (Katz et al, 1994), which emphasizes the need to explore multimodal, non-pharmacological interventions for depressed, frail adults (Schulz & Williamson, 1993;Fairhall et al, 2008), or at least more focused targeting of antidepressant medications that reflects the patient's needs in a holistic manner (Mezuk & Golden, 2009).…”

Section: Discussionmentioning

confidence: 99%

Depression and frailty in later life: a synthetic review

Mezuk

Edwards

Lohman

et al. 2011

Int J Geriat Psychiatry

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219

167

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Background Many of the symptoms, consequences, and risk factors for frailty are shared with late-life depression. However, thus far, few studies have addressed the conceptual and empirical interrelationships between these conditions. This review synthesizes existing studies that examined depression and frailty among older adults and provides suggestions for future research. Methods A search was conducted using PubMed for publications through 2010. Reviewers assessed the eligibility of each report and abstracted information on study design, sample characteristics, and key findings, including how depression and frailty were conceptualized and treated in the analysis. Results Of 133 abstracted articles, 39 full-text publications met inclusion criteria. Overall, both cross-sectional (n = 16) and cohort studies (n = 23) indicate that frailty, its components, and functional impairment are risk factors for depression. Although cross-sectional studies indicate a positive association between depression and frailty, findings from cohort studies are less consistent. The majority of studies included only women and non-Hispanic Whites. None used diagnostic measures of depression or considered antidepressant use in the design or analysis of the studies. Conclusions A number of empirical studies support for a bidirectional association between depression and frailty in later life. Extant studies have not adequately examined this relationship among men or racial/ethnic minorities, nor has the potential role of antidepressant medications been explored. An interdisciplinary approach to the study of geriatric syndromes such as late-life depression and frailty may promote cross-fertilization of ideas leading to novel conceptualization of intervention strategies to promote health and functioning in later life.

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Section: Discussionmentioning

confidence: 99%

Depression and frailty in later life: a synthetic review

Mezuk

Edwards

Lohman

et al. 2011

Int J Geriat Psychiatry

Self Cite

219

167

View full text Add to dashboard Cite

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Intentional Insulin Overdose and Depression in Subjects with and Without Diabetes Mellitus: A Commentary

Gouveri,

Gkouveri,

Popovic

et al. 2024

Diabetes Ther

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Insulin is an essential medication for people with type 1 diabetes mellitus and for some people with type 2 diabetes. Interestingly, insulin abuse has been reported as a mode of suicide, not only among people with diabetes, but also among their relatives, and among medical and paramedical personnel who have access to insulin. The aim of the present commentary was to raise awareness of potential depression-related intentional insulin overdose and its complications, as well as of the diagnosis and treatment of this entity. Insulin overdose may lead to severe and prolonged hypoglycemia, hypoglycemic coma, and death. Moreover, hypokalemia, hypomagnesemia, hypophosphatemia, and elevated liver enzymes are common. Insulin overdose should be suspected among people with diabetes in case of unexplained prolonged hypoglycemia and among people without diabetes who exhibit hypoglycemia and may have access to diabetic medications. The ratio of insulin to C-peptide helps distinguish exogenous insulin administration from endogenous secretion. The cornerstone of therapy is prompt administration of concentrated glucose infusions for days with simultaneous oral intake, when possible, and intense glucose monitoring to prevent hypoglycemia. Moreover, monitoring of serum electrolyte levels is recommended. Finally, psychiatric evaluation aiming at early identification of depression and suicidality is of paramount importance.

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Perte osseuse induite par les antidépresseurs et les neuroleptiques

Breuil

Euller‐Ziegler

2011

Revue du Rhumatisme Monographies

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A link between depression and bone metabolism: what are the implications for treatment?

Cited by 3 publications

References 45 publications

Depression and frailty in later life: a synthetic review

Depression and frailty in later life: a synthetic review

Intentional Insulin Overdose and Depression in Subjects with and Without Diabetes Mellitus: A Commentary

Perte osseuse induite par les antidépresseurs et les neuroleptiques

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