A link between inflammation and thrombosis in atherosclerotic cardiovascular diseases: Clinical and therapeutic implications

The Inflammasome Signaling Pathway Is Actively Regulated and Related to Myocardial Damage in Coronary Thrombi from Patients with STEMI

“…One study has suggested prothrombotic functions of the NLRP3 inflammasome by showing reduced human platelet aggregation response after NLRP3 inhibition in vitro [ 34 ]. Several publications in recent years have described the linkage between inflammation, atherosclerosis, and thrombosis in cardiovascular disease [ 35 , 36 ]. Our findings support the general theory of interplay between innate immune cells, the inflammasome axis, and thrombotic mechanisms actively taking place in human coronary thrombi and may also indicate that the inflammasome-related markers are involved in the formation of intracoronary thrombi.…”

Updating concepts on atherosclerotic inflammation: From pathophysiology to treatment

“…Multiple pro‐inflammatory cytokines indeed act on hepatocytes, promoting the secretion of coagulation factors; furthermore, IL‐6 induces the production of plasminogen activator inhibitor‐1 (PAI‐1) and inhibits the production of antithrombin. Il‐6 inhibits also the cleavage of von Willebrand factor by ADAMTS13, whereas C‐reactive protein (CRP) upregulates TF and inhibits the production of prostaglandins, with the net effect of a pro‐thrombotic and hypo‐fibrinolytic state 28 . Overall, a pro‐inflammatory state would not only drive atherosclerotic plaque instability, but it would also promote a local and systemic pro‐thrombotic state, leading to the formation of larger thrombi and ultimately suffering for severe acute ischaemia after plaque rupture 29 …”

Editorial: Gut Microbiota and Inflammation: Relevance in Cancer and Cardiovascular Disease

“…As previously reported, and recently well-reviewed (Novakovic et al, 2020;Oikonomou et al, 2020), different studies link the interplay microbiota-immune response with cardiovascular diseases, for which hypertension represents the main risk factor. Hypertension is a clinical condition, resulting from a multifaceted interplay of endogenous and environmental factors, where the GM role has been strongly supposed but is still poorly understood.…”