“…In cases in which it was examined, these deletions were not noted in the constitutional (normal) DNA of the patients, indicating that the deletion does not reflect the site of the inherited mutation. LOH has been noted on other chromosomes also, including 3p, l lp, 17p, and chromosome 22q, but LOH for lp has been the most consistent finding to date (Khosla et al,1991;Mathew et al, 1987b;Moley et al, 1992;Takai et al, 1987;Tsutsumi et al, 1989;Yang et al, 1990). This suggests that an important suppressor gene resides on this chromosomal arm, and its loss or inactivation plays a role in the development or progression of pheochromocytomas, at least in a substantial subset of patients.…”