A lipid membrane supported on an artificial extracellular matrix made of polyelectrolyte multilayers: towards nanoarchitectonics at the cellular interface

Abstract

To implement a specific function, cells recognize multiple physical and chemical cues and display molecular responses at their interfaces - boundary regions between cell lipid-based membrane and surrounding extracellular matrix...

Chemistry of Materials Nanoarchitectonics for Two-Dimensional Films: Langmuir–Blodgett, Layer-by-Layer Assembly, and Newcomers

“…Even though biological systems appear to be three-dimensionally complex structures, they are structures of an intertwined two-dimensional membrane and interfacial structures. Therefore, essentially organizing functional molecules into two-dimensional systems such as thin films may be the best strategy of nanoarchitectonics to create highly functional materials similarly to living organisms. − In addition, two-dimensional systems provide opportunities to integrate macroscopic events along the lateral direction and nanoscale phenomena within the thickness direction. Physical chemistry in two-dimensional systems is influenced by different dielectric properties and mechanical natures of contacting two phases.…”