2020
DOI: 10.1039/d0an00335b
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A lipophilic ionic liquid-based dye for anion optodes: importance of dye lipophilicity and application to heparin measurement

Abstract: A fully lipophilic ionic liquid comprising a lipophilic fluorescein anion and a trihexyltetradecylphosphonium cation was synthesized and used as the plasticizer for a PVC membrane optode, demonstrating high sensitivity, rapid, and reversible responses toward anions and heparin.

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Cited by 14 publications
(14 citation statements)
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“…16,17 Following this work, membrane and particle type sensors that rely on an ion exchange between the target ion and an optical reporter were developed further. [18][19][20][21][22] Emulsified (nanoparticle-type) optical sensors have been of particular interest as they allow: assay miniaturization (to the cellular scale 23,24 ), integration of automated liquid handling, and significantly reduced equilibrium times. Unfortunately, nanoparticle-based polyion sensors for reliable measurement in blood, plasma and serum have not yet been successful.…”
Section: Introductionmentioning
confidence: 99%
“…16,17 Following this work, membrane and particle type sensors that rely on an ion exchange between the target ion and an optical reporter were developed further. [18][19][20][21][22] Emulsified (nanoparticle-type) optical sensors have been of particular interest as they allow: assay miniaturization (to the cellular scale 23,24 ), integration of automated liquid handling, and significantly reduced equilibrium times. Unfortunately, nanoparticle-based polyion sensors for reliable measurement in blood, plasma and serum have not yet been successful.…”
Section: Introductionmentioning
confidence: 99%
“…Unfortunately, polyion-selective nanoscale sensors were failing in undiluted serum or plasma, 34,53,59 requiring the use of diluted samples, while the membrane type sensors performed adequately in serum. 62 Likely the most significant difference from cast film sensors is their dramatically larger surface to volume ratio.…”
Section: Polyion Sensing By Controlling Inner Polarity Of the Nanopar...mentioning
confidence: 99%
“…140 nm). 59 However, the sensing mechanism of such modern optode sensors makes use of the same ion exchange principle as the one employed in membrane-type sensors. Although the development of nanoscale optodes in the 2010s significantly improved response time and applicability to polyion detection, 60 the fact remains that the sensing mechanism itself had not changed ever since the first development of polyion optode sensor in the 1990s.…”
Section: Polyion Sensing By Controlling Inner Polarity Of the Nanopar...mentioning
confidence: 99%
“…[24] It is known that many delocalized lipophilic cationic dyes, [25][26][27][28] which have a complete positive charge are easily accumulated and absorbed by living cells. [29] Recently, although many SO 2 Abbreviations used: Cys, cysteine; DMEM, Dulbecco's modified Eagle's medium; DMSO, dimethylsulfoxide; ESI, electrospray ionization; HPLC, high-performance liquid chromatography; HR-MS, high resolution mass spectrascopy; FIA, flow injection analysis; NMR, nuclear magnetic resonance; PBS, phosphate-buffered saline; SD, standard deviation; SO 2 , sulfur dioxide; TBHP, tert-Butyl hydroperoxide; TLC, thin layer chromatography; UV, ultraviolet.…”
Section: Introductionmentioning
confidence: 99%