A Lipotoxic Medium Decreases the Number of Lipid Droplets in β Cells: One Possible Explanation of the β-Cell Failure in Patients With Hyperlipidemia Receiving Tacrolimus

Yilmaz-Yalcin, Yaprak; Tütüncü, Neslihan Başçıl; Baysan-Cebi, H. Pınar; Verdı, Hasıbe; Erol, Suleyman; Kaymaz, Fevziye Figen; Ataç, Fatma Belgin

doi:10.6002/ect.2022.0269

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…In ApoE -/mice, hyperlipidemia promotes lipid deposition and foam cell formation, subsequently leading to atherosclerosis. Lowering blood lipid levels, especially low-density lipoprotein cholesterol (LDL-c) levels, dramatically relieves the risk of CVD (Yilmaz-Yalcin et al, 2022). In aortic diseases, hyperlipidemia serves as a critical factor in the progression of atherosclerosis (AS) (Zhang et al, 2022).…”

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confidence: 99%

Wogonoside improves high-fat diet-induced hyperlipidemia and aortic injury in ApoE -/- mice by upregulating SIRT1 expression

Shen

Zhu²,

Chen³

et al. 2023

Qual. Assur. Saf. Crops Foods

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This study aimed to evaluate the effect of Wogonoside (Wog), a flavonoid monomer, on hyperlipidemia and explore its possible mechanisms. APOE -/- mice were used to establish the animal model of hyperlipidemia by feeding the high-fat diet (HFD). The serum level of triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), and inflammatory cytokines were measured by enzyme-linked immunosorbent assay (ELISA), oil red O staining, and real-time PCR assay. The oxidative stress was measured by ELISA assay. Immunoblot assay and ELISA assay were used to detect the mechanism of Wogonoside on hyperlipidemia. We found that Wogonoside ameliorated lipid metabolism disorders in ApoE -/- mice induced by HFD (P<0.01). Wogonoside also ameliorated HFD-induced inflammation in ApoE -/- mice (P<0.01). Wogonoside ameliorated oxidative stress in HFD-induced ApoE -/- mice (P<0.01). Further study showed that Wogonoside improved HFD-induced hyperlipidemia and inflammation by upregulating SIRT1 expression (P<0.01). These results suggested that Wogonoside has the potential to be used as a promising approach for the intervention of hyperlipidemia.

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Section: Introductionmentioning

confidence: 99%

Wogonoside improves high-fat diet-induced hyperlipidemia and aortic injury in ApoE -/- mice by upregulating SIRT1 expression

Shen

Zhu²,

Chen³

et al. 2023

Qual. Assur. Saf. Crops Foods

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Diabetic Ketoacidosis Management: Updates and Challenges for Specific Patient Population

El-Remessy

2022

Endocrines

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Diabetic ketoacidosis (DKA) is the most common hyperglycemic emergency and causes the greatest risk for death that could be prevented in patients with diabetes mellitus. DKA occurs more commonly among patients with type-1 diabetes with a thirty percent of the cases take place in patients with type 2 diabetes. DKA is characterized by sever hyperglycemia, metabolic acidosis and ketosis. Proper management of DKA requires hospitalization for aggressive replacement and monitoring of fluids, electrolytes and insulin therapy. Management of DKA has been updated with guidelines, to help standardize care, and reduce mortality and morbidity. The major precipitating factors for DKA include new diagnosis of diabetes, non-adherence to insulin therapy as well as infection in patients with diabetes. Discharge plans should include appropriate selection of insulin dosing and regimens as well as patient education to prevent recurrence of DKA. Further, definition and management of euglycemic DKA in patients prescribed sodium-glucose co-transporter 2 inhibitors are discussed. Special consideration is reviewed for specific patient population including pregnancy, renal replacement, acute pancreatitis, and insulin pump users as well as patients with COVID-19.

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A Lipotoxic Medium Decreases the Number of Lipid Droplets in β Cells: One Possible Explanation of the β-Cell Failure in Patients With Hyperlipidemia Receiving Tacrolimus

Cited by 2 publications

References 26 publications

Wogonoside improves high-fat diet-induced hyperlipidemia and aortic injury in ApoE -/- mice by upregulating SIRT1 expression

Wogonoside improves high-fat diet-induced hyperlipidemia and aortic injury in ApoE -/- mice by upregulating SIRT1 expression

Diabetic Ketoacidosis Management: Updates and Challenges for Specific Patient Population

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