2024
DOI: 10.26434/chemrxiv-2024-c7vp2
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A Live-Cell Epigenome Manipulation by Photo-stimuli-responsive Histone Methyltransferase Inhibitor

Chuan-Shuo Wu,
Xin Sun,
Li Liu
et al.

Abstract: Post-translational modifications (PTMs) on the histone H3 tail regulate chromatin structure and impact epigenetics and hence the gene expressions. Current chemical modulation tools, such as unnatural amino acid incorporation, protein splicing, and sortase-based editing, have allowed for the modification of histones with various PTMs in cellular contexts, but most of these methods are not applicable for editing native chromatin. The use of small organic molecules to manipulate histone-modifying enzymes alters e… Show more

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