A Living Material Constructed from Stem Cells for Tumor‐Tropic Oncotherapy with Real‐Time Imaging

Abstract

Progress in targeted drug delivery has changed the landscape of tumor therapy. An efficient drug delivery system with real-time monitoring will boost the therapeutic effect. This study reports a novel living material constructed from living stem cells, nanocarriers, and drugs to achieve targeted delivery with real-time monitoring. The nanocarriers of mesoporous silica-coated super-paramagnetic Fe 3 O 4 nanoparticles (Fe 3 O 4 @MSNPs) are connected to human adipose-derived stem cells (hADSCs) by anti-CD44 antibody bioconjugation. The inherent tumor tropism of hADSCs provides targeting ability. Drug delivery can be performed without endocytosis for drug loading based on antibody bioconjugation and high drug loading. This method also reduces the drug effect on hADSCs and results in long troop migration toward tumors for doxorubicin delivery. Successful doxorubicin delivery induces the apoptosis of Michigan Cancer Foundation-7 (MCF-7) tumor cells. Magnetic resonance imaging of super-paramagnetic Fe 3 O 4 nanoparticles shows the real-time monitoring ability of the proposed living material, which can confirm targeted drug delivery. This study provides a living material design strategy for oncotherapy.

Engineered Living Materials For Sustainability

“…Gelatin derivatives, particularly gelMA, can be rapidly photo-cross-linked into a 3D network with durable structural stability at physiological temperatures. They have been used as scaffolding materials to encapsulate various prokaryotic or eukaryotic cells. , In a study led by Cui et al, researchers created living materials composed of gelatin, GelMA, and Streptococcus zooepidemicus for the catalytic synthesis of HA . The gelatin/GelMA composites exhibited typical shear-thinning behavior and temperature-dependent rheology, which facilitated the 3D printing of the gels.…”

Concerting magnesium implant degradation facilitates local chemotherapy in tumor-associated bone defect

“…Moreover, traditional chemo/radiotherapy are often associated with inevitable problems including severe side effects of drugs to healthy tissues or even systemic toxicity, the development of resistance, and inadequate bioeffects on the defected bone tissues [ [9] , [10] , [11] ]. It thus motivates efforts to develop innovative therapeutic options with compelling biosafety and efficacy, among which local bone therapy [ [12] , [13] , [14] ] through the employment of a drug carrier or implant biomaterial to diseased bone tissue has recently emerged as an attractive strategy [ 15 ].…”

CD44 and HAP‐Conjugated hADSCs as Living Materials for Targeted Tumor Therapy and Bone Regeneration

“…[ 14 ] In our previous work, we modified mesoporous silica‐coated superparamagnetic Fe 3 O 4 nanoparticles with Anti‐CD44 antibodies to tightly bind to human adipose–derived stem cells (hADSCs), resulting in living materials with high drug delivery efficiency. [ 15 ] Notably, as discussed above, the occupancy of lesions as soon as possible is critical for efficient osteosarcoma therapy. Therefore, spontaneous bone regeneration would play an indispensable role in enhancing tumor treatment after surgery.…”