2015
DOI: 10.1242/jcs.168674
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A local VE-cadherin/Trio-based signaling complex stabilizes endothelial junctions through Rac1

Abstract: Endothelial cell-cell junctions maintain a restrictive barrier that is tightly regulated to allow dynamic responses to permeability-inducing angiogenic factors, as well as to inflammatory agents and adherent leukocytes. The ability of these stimuli to transiently remodel adherens junctions depends on Rho-GTPase-controlled cytoskeletal rearrangements. How the activity of Rho-GTPases is spatio-temporally controlled at endothelial adherens junctions by guanine-nucleotide exchange factors (GEFs) is incompletely un… Show more

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Cited by 87 publications
(118 citation statements)
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“…Moreover, actin dynamics tightly control the assembly and disassembly of VE-cadherin-based junctions [19, 20]. In cultured endothelial cells, the formation and stabilization of cell–cell adhesions are promoted by actin-protrusive structures that locate at or near the junctions [2123]. In mature stabilized junctions, VE-cadherin is linearly or continuously organized between cells and supported by parallel running cortical actin bundles [23, 24].…”
Section: Mechanical Regulation Of Endothelial Cell–cell Junctionsmentioning
confidence: 99%
“…Moreover, actin dynamics tightly control the assembly and disassembly of VE-cadherin-based junctions [19, 20]. In cultured endothelial cells, the formation and stabilization of cell–cell adhesions are promoted by actin-protrusive structures that locate at or near the junctions [2123]. In mature stabilized junctions, VE-cadherin is linearly or continuously organized between cells and supported by parallel running cortical actin bundles [23, 24].…”
Section: Mechanical Regulation Of Endothelial Cell–cell Junctionsmentioning
confidence: 99%
“…Rac1 activity also serves to promote VE-Cadherin stability by locally counteracting actomysoin force on VE-cadherin trans-dimers [39]. Recent evidence suggests that the AJ mechanotransduction complex may be able to spatially control the activation of Rac1 through the local recruitment of the GEF Trio to VE-cadherin [40]. …”
Section: Molecular Force Sensing and Mechanotransductionmentioning
confidence: 99%
“…3a–b). The Rho-family GTPases are powerful regulators of actin redistribution and barrier function 20 , where Rac1 can stabilize AJs by promoting the formation of cortical actin bundles 21 . Indeed, Notch1-KO cells and ECs treated with DAPT exhibited reduced Rac1 activity (Fig.…”
mentioning
confidence: 99%