A localized salt-dependent aquagenic urticaria successfully treated with omalizumab

Carra, Sophie; Dereure, O.; Raison‐Peyron, Nadia

doi:10.1111/ced.15346

Clinical and Experimental Dermatology

2022

DOI: 10.1111/ced.15346

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A localized salt-dependent aquagenic urticaria successfully treated with omalizumab

Sophie Carra

O. Dereure

Nadia Raison‐Peyron

Abstract: We present the first case of a localized salt-dependent aquagenic urticaria confirmed by a challenge test. A good therapeutic response was achieved after only the first dose of omalizumab.

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2024

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Cited by 3 publications

References 8 publications

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New insights into chronic inducible urticaria

Muñoz,

Kiefer,

Pereira

et al. 2024

Curr Allergy Asthma Rep

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Purpose of Review Chronic inducible urticaria (CIndU) is a group of long-persisting and challenging to manage diseases, characterized by recurrent wheals and angioedema induced by definite triggers. In this review, we address recent findings on CIndU pathogenesis, diagnosis as well as its treatment, and we discuss novel potential targets that may lead to the development of more effective therapies for CIndU patients. Recent Advances Meaningful advances in the understanding of its pathogenesis have been reported in the last decades. Novel CIndU-specific patient-reported outcome measures enable a closer and better evaluation of patients. Summary CIndU is a hard-to-treat disease that highly impairs quality of life (QoL) of affected patients. Provocation tests allow to diagnose CIndU subtypes. The only licensed and recommended treatment for CIndU are second generation non-sedating H1-antihistamines, which lack efficacy in many cases. Omalizumab off-label use has been assessed in all types of CIndU with overall good outcomes. Promising emerging therapies currently assessed in chronic spontaneous urticaria are paving the path for novel treatments for CIndU

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New insights into chronic inducible urticaria

Muñoz,

Kiefer,

Pereira

et al. 2024

Curr Allergy Asthma Rep

View full text Add to dashboard Cite

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Aquagenic urticaria in an adolescent: differential diagnosis and management

Bajoghli,

Parlak,

Bajoghli

2024

BMJ Case Rep

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Aquagenic urticaria, a rare variant of chronic-inducible urticaria, is triggered by direct contact with water. It is distinguished by its characteristic small wheals accompanied by a halo of erythema from other forms of urticaria. It typically manifests with a delayed diagnosis due to the atypical trigger and the potential for diverse clinical presentations. We present a case of aquagenic urticaria in an adolescent male that demonstrates the need for accurate differential diagnosis and appropriate management.

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Aquagenic urticaria: presentation, diagnosis and management

Abdi,

Diamond,

Stuckless

2024

BMJ Case Rep

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Aquagenic urticaria, a rare dermatological condition characterised by urticarial eruptions following water contact, poses significant diagnostic and therapeutic challenges. This condition, although uncommon, necessitates heightened clinical awareness due to its substantial impact on the patient’s quality of life. We present a comprehensive account of a paediatric case involving a girl in her mid-teens, who developed recurrent wheals post-exposure to water, independent of its temperature or source. Diagnosis hinged on a detailed clinical history and a definitive water provocation test, with routine laboratory assessments yielding no contributory findings. The therapeutic regimen featuring cetirizine yielded significant symptomatic relief. Although antihistamines are the cornerstone of treatment, the differential response among individuals necessitates an individualised approach, considering adjunctive treatments such as omalizumab and ultraviolet therapy. This case reinforces the critical role of clinical acumen in the recognition and diagnosis of aquagenic urticaria and calls for further research into its pathophysiology to refine treatment strategies.

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A localized salt-dependent aquagenic urticaria successfully treated with omalizumab

Abstract: We present the first case of a localized salt-dependent aquagenic urticaria confirmed by a challenge test. A good therapeutic response was achieved after only the first dose of omalizumab.

Cited by 3 publications

References 8 publications

New insights into chronic inducible urticaria

New insights into chronic inducible urticaria

Aquagenic urticaria in an adolescent: differential diagnosis and management

Aquagenic urticaria: presentation, diagnosis and management

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