A Localized Surface Plasmon Resonance-Based Portable Instrument for Quick On-Site Biomolecular Detection

Rampazzi, Sara; Danese, Giovanni; Leporati, Francesco; Marabelli, F.

doi:10.1109/tim.2015.2465691

Cited by 45 publications

(29 citation statements)

References 42 publications

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“…The outputs from all the system are sent to personal computer (PC) via serial interface for signal processing. In another configuration [16], a multichannel SPR system is developed by using a prism based approach. The two-channel SPR system is demonstrated by introducing two flow channels on a single SPR chip.…”

Section: Introductionmentioning

confidence: 99%

Realization of Low-Cost Multichannel Surface Plasmon Resonance Based Optical Transducer

2018

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This paper demonstrates a low-cost and portable multichannel surface plasmon resonance (SPR) based optical transducer. The system's portability is achieved through the development of compact web-cam based spectrometer, and edge coupling to the SPR chip. Here, two configurations are presented: single-channel integrated system and two-channel system where the SPR chip and the spectrometer are coupled by a pair of plastic optical fibers. For the two-channel configuration, two different approaches are utilized to extract the optical spectrum: manual region cropping and automatic regions detection. For both approaches, image distortion and the size of the fiber tip affect the measured spectrum. For all configurations, mechanical alignment and mounting are made by 3D printing. The developed systems are tested with water and glycerol solution of different concentrations. The measured sensitivity is in the order of 10-4 RIU (refractive index unit) for all systems under the ambient condition.

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Section: Introductionmentioning

confidence: 99%

Realization of Low-Cost Multichannel Surface Plasmon Resonance Based Optical Transducer

2018

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“…technologies have been increasingly investigated-including medical devices for in vitro diagnosis and point-of-care (PoC) systems-supported also by the growing interest toward customized and personalized medicine and toward rapid and home-accessible portable diagnostic systems [1]- [3].…”

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confidence: 99%

“…Furthermore, user safety and sample sterility can also be addressed by implementing wireless module, as highlighted in [3].…”

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confidence: 99%

“…More specifically in order to allow an efficient transduction of physiological processes into quantifiable signal, combinations of potentiostats and galvanostats standard designs have been investigated in different solutions [13]. Additionally, a great interest was related to combine innovative detection techniques (including label-free techniques based on optical, mechanical and electrochemical transducers) with their optimal conditioning circuit in order to realize fast, portable, and easily usable devices aiming to smart bio sensing and to bring a significant improvement to clinical daily practice [3], [14]. However, among the various technologies proposed for the realization of PoC systems, no reliable, quantitative, and sensitive devices for specific protein detection have been yet commercialized.…”

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confidence: 99%

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Wireless Point-of-Care Platform With Screen-Printed Sensors for Biomarkers Detection

Tonello

Abate

Borghetti

et al. 2017

IEEE Trans. Instrum. Meas.

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Abstract-Measurement systems for early and reliable detection of degenerative diseases, such as Alzheimer's disease (AD), are extremely important in clinical diagnosis. Among these, biochemical assays represent a commonly used method to distinguish patients from healthy population thanks to the sensitive recognition of specific biomarkers in biological fluids. In order to overcome actual limitations of these techniques in term of cost, standardization, and sensitivity, this study aimed to realize a low-cost highly sensitive portable point-of-care (PoC) testing system based on screen-printed electrochemical sensors. The development of the platform specifically included both the design of the sensing probe and the electronic circuit devoted to condition and acquires the transduced electric signal. The designed circuit was implemented in a printed circuit board and interfaced to a wireless system based on bluetooth data transmission in order to improve the portability of the proposed solution. Preliminary results were obtained by using controlled concentrations of electrolytic solutions and calibrating the sensors for antibodies and for a well-known protein (i.e., interleukin 8) quantified by anodic stripping voltammetry (ASV). Findings from ASV measurements showed a sensitivity of 38 µA/(ng/ml) with a tested range from 1.25 to 20 ng/ml, with a limit of detection of 2 ng/ml. Further investigation will include the validation of this PoC device by testing the concentration of a specific p53 protein isoform, which was recently identified to early correlate to AD development.

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“…The device was fabricated on indium tin oxide-coated glass substrates, with a patterned coating of Teflon-AF and gold or silver electrodeposited electrodes 102 . In another example, a low-cost device that uses localized surface plasmon resonance was built for detection of various biomolecules 103 . While these devices greatly simplify traditionally difficult laboratory processes, they do require a few steps of pipetting which are best performed by trained personnel.…”

Section: Recent Developments In Poc Diagnosticsmentioning

confidence: 99%

Point-of-Care Diagnostics: Recent Developments in a Connected Age

et al. 2016

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A Localized Surface Plasmon Resonance-Based Portable Instrument for Quick On-Site Biomolecular Detection

Cited by 45 publications

References 42 publications

Realization of Low-Cost Multichannel Surface Plasmon Resonance Based Optical Transducer

Realization of Low-Cost Multichannel Surface Plasmon Resonance Based Optical Transducer

Wireless Point-of-Care Platform With Screen-Printed Sensors for Biomarkers Detection

Point-of-Care Diagnostics: Recent Developments in a Connected Age

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