A locus telomeric toHLA-DPB encodes susceptibility to coeliac disease

Rosenberg, William; Wordsworth, B P; Jewell, D P; Bell, John I.

doi:10.1007/bf02421336

Cited by 52 publications

(29 citation statements)

References 16 publications

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“…Studies in different ethnic groups are necessary to clarify that matter further. Interestingly, recent reports have identified distinct au toimmune diseases being linked to some HLA-DR/ DQ-DP haplotypes [16][17][18]. Similar to other studies [11,19] we observed strong LD between HLA-DPB1 and HLA-DQA1 loci only in some haplotypes.…”

Section: Statistical Analysessupporting

confidence: 78%

Detection of Established and Novel Alleles of the HLA-DPB1 Locus by PCR-SSO

Pickl¹,

Faé²,

Fischer³

1993

Vox Sanguinis

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The polymorphism at the HLA-DPB1 locus was investigated in 490 Austrian individuals. Exon 2 sequences of the HLA-DPB1 genes were amplified by polymerase chain reaction and probed with a panel of sequence-specific oligonucleotide probes. HLA-DPB1 genotypes were deduced from the hybridization pattern of the probes. HLA-DPB1 allele frequencies and Hardy-Weinberg equilibrium were calculated. Linkage disequilibria between HLA-DPB1 and HLA-DQA1 alleles were determined. Four novel hybridization patterns indicating new alleles were found.

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Section: Statistical Analysessupporting

confidence: 78%

Detection of Established and Novel Alleles of the HLA-DPB1 Locus by PCR-SSO

Pickl¹,

Faé²,

Fischer³

1993

Vox Sanguinis

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“…Earlier case-control studies have found increased risks of both dermatitis herpetiformis and celiac disease associated with DPB1*01:01 in white populations, including those residing in the United Kingdom. 40,41 More recently, a large study found that, along with other HLA class II alleles, DPB1*01:01 is associated with an increased susceptibility to sarcoidosis in a United States black population. 42 The evaluation of interaction between DP1 supertypes and proxy measures in the risk of childhood ALL showed that the increased risk associated with DP1 is only found in children cALL indicates common ALL; E, glutamic acid; G, glycine; L, leucine; D, aspartic acid; and K, lysine.…”

Section: Discussionmentioning

confidence: 99%

HLA-DP genetic variation, proxies for early life immune modulation and childhood acute lymphoblastic leukemia risk

Urayama

Chokkalingam

Metayer

et al. 2012

Blood

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The human leukocyte antigen (HLA) genes are candidate genetic susceptibility loci for childhood acute lymphoblastic leukemia (ALL). We examined the effect of HLA-DP genetic variation on risk and evaluated its potential interaction with 4 proxies for early immune modulation, including measures of infectious exposures in infancy (presence of older siblings, daycare attendance, ear infections) and breastfeeding. A total of 585 ALL cases and 848 controls were genotyped at the HLA-DPA1 and DPB1 loci. Because of potential heterogeneity in effect by race/ethnicity, we included only nonHispanic white (47%) and Hispanic (53%) children and considered these 2 groups separately in the analysis.

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“…This is most clearly evident in coeliac disease where two distinct susceptibility alleles are present on the B8 DR3 haplotype [58]. This is most clearly evident in coeliac disease where two distinct susceptibility alleles are present on the B8 DR3 haplotype [58].…”

Section: Non-hla Candidate Genes Encoded Within the Mhcmentioning

confidence: 94%