A Long Non-coding RNA IVRPIE Promotes Host Antiviral Immune Responses Through Regulating Interferon β1 and ISG Expression

Zhao, Lingna; Xia, Min; Wang, Keyu; Chen, Lai; Fan, Hongxia; Gu, Huiying; Yang, Peng; Wang, Xiliang

doi:10.3389/fmicb.2020.00260

Cited by 45 publications

(44 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consequently, NRAV negatively regulates the initial transcription of ISGs 10 . Similarly, another lncRNA named IVRPIE positively regulates the expression of various ISGs, including IRF1, IFIT1, IFIT3, Mx1, ISG15, and IFI44L, by increasing H3K4me3 and impairing H3K27me3 in TSSs of these genes 77 . However, IVRPIE also affects the expression of IFN-β 77 ; therefore, the effect of lncRNA IVRPIE on IFN-β may affect the expression of ISGs.…”

Section: Roles Of Lncrnas In Innate Antiviral Responsementioning

confidence: 99%

“…Similarly, another lncRNA named IVRPIE positively regulates the expression of various ISGs, including IRF1, IFIT1, IFIT3, Mx1, ISG15, and IFI44L, by increasing H3K4me3 and impairing H3K27me3 in TSSs of these genes 77 . However, IVRPIE also affects the expression of IFN-β 77 ; therefore, the effect of lncRNA IVRPIE on IFN-β may affect the expression of ISGs. In addition to host-encoded lncRNAs, many viruses themselves generate lncRNAs implicated in their life cycle 7 .…”

Section: Roles Of Lncrnas In Innate Antiviral Responsementioning

confidence: 99%

See 1 more Smart Citation

Roles of long non-coding RNAs and emerging RNA-binding proteins in innate antiviral responses

Wang

Luo

et al. 2020

Theranostics

View full text Add to dashboard Cite

The diseases caused by viruses posed a great challenge to human health, the development of which was driven by the imbalanced host immune response. Host innate immunity is an evolutionary old defense system that is critical for the elimination of the virus. The overactive innate immune response also leads to inflammatory autoimmune diseases, which require precise control of innate antiviral response for maintaining immune homeostasis. Mounting long non-coding RNAs (lncRNAs) transcribed from the mammalian genome are key regulators of innate antiviral response, functions of which greatly depend on their protein interactors, including classical RNA-binding proteins (RBPs) and the unconventional proteins without classical RNA binding domains. In particular, several emerging RBPs, such as m 6 A machinery components, TRIM family members, and even the DNA binding factors recognized traditionally, function in innate antiviral response. In this review, we highlight recent progress in the regulation of type I interferon signaling-based antiviral responses by lncRNAs and emerging RBPs as well as their mechanism of actions. We then posed the future perspective toward the role of lncRNA-RBP interaction networks in innate antiviral response and discussed the promising and challenges of lncRNA-based drug development as well as the technical bottleneck in studying lncRNA-protein interactions. Our review provides a comprehensive understanding of lncRNA and emerging RBPs in the innate antiviral immune response.

show abstract

Section: Roles Of Lncrnas In Innate Antiviral Responsementioning

confidence: 99%

Section: Roles Of Lncrnas In Innate Antiviral Responsementioning

confidence: 99%

Roles of long non-coding RNAs and emerging RNA-binding proteins in innate antiviral responses

Wang

Luo

et al. 2020

Theranostics

View full text Add to dashboard Cite

show abstract

“…Infections with influenza virus (IAV), HIV, herpes simplex virus (HSV), hepatitis C virus (HCV), hepatitis B virus (HBV), severe acute respiratory syndrome coronavirus (SARS-CoV) and others alter the expression of host lncRNA 19 , 20 . Expression of lncRNA EGOT, NEAT1, BISPR/LncBST2, LINC01191/VIN/lnc-ACTR3, ISR (IFN-stimulated lncRNA) 2 and ISR8, LOC100506319/LINC01988/LncRNA-PAAN, LOC102637961/lncRNA-ACOD1, MIR155HG, TSPOAP1-AS1, PSMB8-AS1, PSORS1C3, IVRPIE was increased and expression of NRAV/DYNLL1AS1 was decreased in IAV infected cells 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 . In HIV infected cells expression of ISR2, NEAT1, GOMAFU/MIAT, LUST/RBM5-AS1, BIC/MIR155HG, MALAT1, NRIR/lncCMPK2, MIR3945HG, FIRRE, LINC02574, LINC01426 is increased while expression of NRON, PANDAR/PANDA, CDKN2B-AS1/ANRIL DD3/PCA, DANCR, CMPD/LINC01152, NCRMS/RMST, GAS5, LINC00173, lincRNA-p21/TP53COR1 and SAF/FAS-AS1 is decreased 29 , 30 , 31 .…”

Section: Introductionmentioning

confidence: 99%

In silico analysis of altered expression of long non-coding RNA in SARS-CoV-2 infected cells and their possible regulation by STAT1, STAT3 and interferon regulatory factors

Laha

Saha

Dutta

et al. 2021

Heliyon

View full text Add to dashboard Cite

Altered expression of long noncoding RNA (lncRNA), longer than 200 nucleotides without potential for coding protein, has been observed in diverse human diseases including viral diseases. It is largely unknown whether lncRNA would deregulate in SARS-CoV-2 infection, causing ongoing pandemic COVID-19. To identify, if lncRNA was deregulated in SARS-CoV-2 infected cells, we analyzed in silico the data in GSE147507. It was revealed that expression of 20 lncRNA like MALAT1, NEAT1 was increased and 4 lncRNA like PART1, TP53TG1 was decreased in at least two independent cell lines infected with SARS-CoV-2. Expression of NEAT1 was also increased in lungs tissue of COVID-19 patients. The deregulated lncRNA could interact with more than 2800 genes/proteins and 422 microRNAs as revealed from the database that catalogs experimentally determined interactions. Analysis with the interacting gene/protein partners of deregulated lncRNAs revealed that these genes/proteins were associated with many pathways related to viral infection, inflammation and immune functions. To find out whether these lncRNAs could be regulated by STATs and interferon regulatory factors (IRFs), we used ChIPBase v2.0 that catalogs experimentally determined binding from ChIP-seq data. It was revealed that any one of the transcription factors IRF1, IRF4, STAT1, STAT3 and STAT5A had experimentally determined binding at regions within -5kb to +1kb of the deregulated lncRNAs in at least 2 independent cell lines/conditions. Our analysis revealed that several lncRNAs could be regulated by IRF1, IRF4 STAT1 and STAT3 in response to SARS-CoV-2 infection and lncRNAs might be involved in antiviral response. However, these in silico observations are necessary to be validated experimentally.

show abstract

“…It is currently unknown whether these hnRNPs function to stabilize or guide the lncRNA to the proper cellular context or if they are adaptors that help interaction between the lncRNA and transcription regulators. Binding to hnRNPU was described to mediate the chromatin state changes behind IVRPIE (inhibiting IAV replication by promoting IFN and ISG expression) regulation of the antiviral response during IAV infection [172]. IVRPIE is upregulated in patients with acute IAV and limits IAV replication by increasing mRNA and protein levels of IFN-β1, and some critical ISGs, including IRF1, IFIT1, IFIT3, MxA, ISG15, and IFI44L.…”

Section: Lncrnas Can Positively Regulate the Transcription Of Isgs Anmentioning

confidence: 99%

LncRNAs in the Type I Interferon Antiviral Response

Suarez

Prats-Mari

Unfried

et al. 2020

IJMS

View full text Add to dashboard Cite

The proper functioning of the immune system requires a robust control over a delicate equilibrium between an ineffective response and immune overactivation. Poor responses to viral insults may lead to chronic or overwhelming infection, whereas unrestrained activation can cause autoimmune diseases and cancer. Control over the magnitude and duration of the antiviral immune response is exerted by a finely tuned positive or negative regulation at the DNA, RNA, and protein level of members of the type I interferon (IFN) signaling pathways and on the expression and activity of antiviral and proinflammatory factors. As summarized in this review, committed research during the last decade has shown that several of these processes are exquisitely regulated by long non-coding RNAs (lncRNAs), transcripts with poor coding capacity, but highly versatile functions. After infection, viruses, and the antiviral response they trigger, deregulate the expression of a subset of specific lncRNAs that function to promote or repress viral replication by inactivating or potentiating the antiviral response, respectively. These IFN-related lncRNAs are also highly tissue- and cell-type-specific, rendering them as promising biomarkers or therapeutic candidates to modulate specific stages of the antiviral immune response with fewer adverse effects.

show abstract

A Long Non-coding RNA IVRPIE Promotes Host Antiviral Immune Responses Through Regulating Interferon β1 and ISG Expression

Cited by 45 publications

References 38 publications

Roles of long non-coding RNAs and emerging RNA-binding proteins in innate antiviral responses

Roles of long non-coding RNAs and emerging RNA-binding proteins in innate antiviral responses

In silico analysis of altered expression of long non-coding RNA in SARS-CoV-2 infected cells and their possible regulation by STAT1, STAT3 and interferon regulatory factors

LncRNAs in the Type I Interferon Antiviral Response

Contact Info

Product

Resources

About