A Long Non-Coding RNA snaR Contributes to 5-Fluorouracil Resistance in Human Colon Cancer Cells

Lee, Heejin; Kim, Chongtae; Ku, Ja Lok; Kim, Wook; Yoon, Sungjoo Kim; Kuh, Hyo-Jeong; Lee, Jeong Hwa; Nam, Suk Woo; Lee, Eun K.yung

doi:10.14348/molcells.2014.0151

Cited by 71 publications

(57 citation statements)

References 46 publications

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“…[100][101][102][103][104][105][106][107][108] The LncRNAs may provide potential guides to complex with chromatinmodifying proteins and recruit their catalytic activity to specific sites in the genome, thereby modifying chromatin states and modulating gene expression. 109,110 For instance, lncRNA has functional links with PRC2, 110 and the direct interactions between PRC2 and RepA/Xist RNAs target PRC2 in cis to the mammalian X chromosome. 111 The involvement of lnc RNAs would provide targeting specificity and introduce new regulatory capabilities.…”

Section: Histone Modifications In Uterine Leiomyomamentioning

confidence: 99%

The Mechanism and Function of Epigenetics in Uterine Leiomyoma Development

et al. 2016

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Uterine leiomyomas, also known as uterine fibroids, are the most common pelvic tumors, occurring in nearly 70% of all reproductive-aged women and are the leading indication for hysterectomy worldwide. The development of uterine leiomyomas involve a complex and heterogeneous constellation of hormones, growth factors, stem cells, genetic, and epigenetic abnormalities. An increasing body of evidence emphasizes the important contribution of epigenetics in the pathogenesis of leiomyomas. Genome-wide methylation analysis demonstrates that a subset of estrogen receptor (ER) response genes exhibit abnormal hypermethylation levels that are inversely correlated with their RNA expression. Several tumor suppressor genes, including Kruppel-like factor 11 (KLF11), deleted in lung and esophageal cancer 1 (DLEC1), keratin 19 (KRT19), and death-associated protein kinase 1 (DAPK1) also display higher hypermethylation levels in leiomyomas when compared to adjacent normal tissues. The important role of active DNA demethylation was recently identified with regard to the ten-eleven translocation protein 1 and teneleven translocation protein 3-mediated elevated levels of 5-hydroxymethylcytosine in leiomyoma. In addition, both histone deacetylase and histone methyltransferase are reported to be involved in the biology of leiomyomas. A number of deregulated microRNAs have been identified in leiomyomas, leading to an altered expression of their targets. More recently, the existence of side population (SP) cells with characteristics of tumor-initiating cells have been characterized in leiomyomas. These SP cells exhibit a tumorigenic capacity in immunodeficient mice when exposed to 17b-estradiol and progesterone, giving rise to fibroid-like tissue in vivo. These new findings will likely enhance our understanding of the crucial role epigenetics plays in the pathogenesis of uterine leiomyomas as well as point the way to novel therapeutic options.

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Section: Histone Modifications In Uterine Leiomyomamentioning

confidence: 99%

The Mechanism and Function of Epigenetics in Uterine Leiomyoma Development

et al. 2016

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“…Long non‐coding RNAs (lncRNAs) constitute a novel heterogeneous class of non‐coding RNAs, which range from 200 nucleotides to multiple kilobases and account for much of the transcribed genome . Increasing evidence has demonstrated the key roles of lncRNAs in regulating multiple major physiological and pathological processes, including proliferation, cell growth, apoptosis, metastasis, metabolism, development, differentiation, senescence, self‐renewal, stem‐cell pluripotency, immune response, and drug resistance . Epithelial‐to‐mesenchymal transition (EMT) is one of the underlying mechanisms of colonic cancer progression.…”

Section: Introductionmentioning

confidence: 99%

Long non‐coding ribonucleic acid zinc finger antisense 1 promotes the progression of colonic cancer by modulating ZEB1 expression

Fang

Zan

Yue

et al. 2017

J of Gastro and Hepatol

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“…Research is urgently warranted to fully understand and overcome it. Evidence that lncRNAs are involved in chemotherapy resistance is increasing (20)(21)(22), but to the best of our knowledge there is little data on the correlations between lncRNAs and paclitaxel resistance in human lung adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Microarray expression profile of long non-coding RNAs in paclitaxel-resistant human lung adenocarcinoma cells

Tian

Zhang

et al. 2017

Oncology Reports

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Abstract. Paclitaxel (PTX)-based chemotherapy is a standard treatment for human lung adenocarcinoma, but treatment often fails since resistance develops. Recent studies have described the activity of long non-coding RNAs (lncRNAs) in many biological processes and human diseases. Chemotherapy resistance is one of these areas, but the role of lncRNAs in paclitaxel resistance of human lung adenocarcinoma cells has not been reported. A paclitaxel resistance model was established using A549 human lung adenocarcinoma cells. lncRNAs and mRNAs were profiled in parental A549 and paclitaxel-resistant A549/PTX cells by microarray analysis. Real-time quantitative PCR (RT-qPCR) was used to validate the results of the microarray. Chromosomal distribution patterns of differentially expressed lncRNAs and mRNAs were assessed. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed using gene set enrichment. We screened 1,154 lncRNAs and 1,733 mRNAs that had a >3-fold difference in expression in A549/PTX cells compared with A549 cells, most of which were downregulated. Nine lncRNAs and six mRNAs were randomly selected and validated by RT-qPCR. Most aberrantly expressed lncRNAs and mRNAs were located on chromosomes 1, 2, 6, 12 and 17, particularly on chromosome 1. Bioinformatics, GO and KEGG pathway analyses, revealed that some differentially expressed genes regulated classical functions and pathways such as cytosol components, protein binding, gene expression and metabolic pathways. Differential expression of lncRNAs and mRNAs in A549/PTX and A549 cells indicates that various lncRNAs may be useful diagnostic or prognostic markers of resistance to treatment, or future targets for paclitaxel-based chemotherapy, providing a novel rationale for clinical treatment.

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A Long Non-Coding RNA snaR Contributes to 5-Fluorouracil Resistance in Human Colon Cancer Cells

Cited by 71 publications

References 46 publications

The Mechanism and Function of Epigenetics in Uterine Leiomyoma Development

The Mechanism and Function of Epigenetics in Uterine Leiomyoma Development

Long non‐coding ribonucleic acid zinc finger antisense 1 promotes the progression of colonic cancer by modulating ZEB1 expression

Microarray expression profile of long non-coding RNAs in paclitaxel-resistant human lung adenocarcinoma cells

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