A long-term study of interstitial lung disease in systemic lupus erythematosus

Weinrib, Lisa; Sharma, Om P.; Quismorio, Francisco P.

doi:10.1016/0049-0172(90)90094-v

Cited by 141 publications

(80 citation statements)

References 18 publications

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“…It is noteworthy that the significant differences in mean total and weighted DS at 5 and lOyr seem to reflect to a great extent the differences in renal DS. These two findings, being in accordance with the literature [3,4,11,12], demonstrate prognostic validity for the pulmonary and renal item of the SLICC/ACR Damage Index.…”

Section: Discussionsupporting

confidence: 79%

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Slicc/Acr Damage Index Is Valid, and Renal and Pulmonary Organ Scores Are Predictors of Severe Outcome in Patients With Systemic Lupus Erythematosus

Stoll¹,

Seifert²,

Isenberg³

1996

Rheumatology

226

139

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SUMMARYWe investigated the Systemic Lupus International Collaborative Clinics/American College of Rheumatology (SLICC/ACR) Damage Index as a predictor of severe outcome and an indicator of morbidity in different ethnic groups, and in regard to its validity. We retrospectively studied disease course within 10 yr of diagnosis in an inception cohort of 80 patients with systemic lupus erythematosus (SLE). The mean renal damage score (DS) at 1 yr after diagnosis was a significant predictor of endstage renal failure and the mean pulmonary DS at 1 yr significantly predicted death within 10 yT of diagnosis. Compared to Caucasians, Afro-Caribbeans and Asians had significantly higher mean total DS at 5 and 10 yr, and higher mean renal DS at 10 yr. At 5 yr, the mean renal DS in Afro-Caribbeans and the mean neuropsychiatric DS in Asians were significantly higher than in Caucasians. The rate of endstage renal failure in Caucasians was significantly lower than in the other ethnic groups. Our results confirm the validity of the SLICC/ACR Damage Index.

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Section: Discussionsupporting

confidence: 79%

“…The relevant items in those who died were either pulmonary fibrosis or pulmonary hypertension (Table II). This was predictable, as interstitial lung disease [11] and pulmonary hypertension in SLE [12] are known to increase mortality. The mean renal DS at 1 yr significantly correlated with the development of ESRF.…”

Section: Discussionmentioning

confidence: 99%

Slicc/Acr Damage Index Is Valid, and Renal and Pulmonary Organ Scores Are Predictors of Severe Outcome in Patients With Systemic Lupus Erythematosus

Stoll¹,

Seifert²,

Isenberg³

1996

Rheumatology

226

139

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“…Acute lupus pneumonitis consisting of pulmonary infiltrates and atelectasis, occurs in 10–15% of children with SLE. Chronic interstitial lung disease has been reported in adults with SLE [17,20], but not in children. Cystic lesions similar to the finding in the imaging of patient no.…”

Section: Discussionmentioning

confidence: 99%

Prolidase deficiency associated with systemic lupus erythematosus (SLE): single site experience and literature review

et al. 2012

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IntroductionProlidase deficiency (PD) is a rare autosomal recessive disorder which may have a wide spectrum of clinical features. These features include a characteristic facies, cognitive impairment, rashes or skin ulceration, splenomegaly, recurrent infections involving mainly the respiratory system, and iminodipeptiduria. The disorder is caused by a mutation in the PEPD gene.ObjectiveTo describe a cohort of unrelated PD patients from Northern Israel whose inborn error of metabolism was associated with systemic lupus erythematosus (SLE) and to identify in the medical literature all PD cases mimicked by and/or associated with SLE.MethodsThree patients with PD associated with SLE were clinically, biochemically and genetically investigated. These patients were from 3 unrelated consanguineous families residing in Northern Israel. A computer-assisted (PubMed) search of the medical literature from 1975 to 2011 was performed using the following key words: Prolidase deficiency, SLE, and systemic lupus erythematosus.ResultsAn association between PD and SLE was found in 10 PD patients. These 10 patients included three from our cohort of 23 PD patients, and seven out of just under 70 PD patients previously reported in the literature.ConclusionThe present findings underscore the relatively high incidence of the association between SLE and PD, suggesting that this association may not be coincidental. The phenotypic similarities between SLE and PD might suggest that the PEPD gene constitutes a modifier gene or a genetic risk factor in the causation of SLE.

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“…(Kamen & Strange, 2010) Any part of the pulmonary system can be affected including airways, lung parenchyma, pulmonary vasculature, pleura and diaphragm. (Gross et al, 1972;Haupt et al, 1981;Kamen & Strange, 2010;Orens et al, 1994;Quadrelli et al, 2009;Weinrib et al, 1990) If SLE develops after age 49 years, it has a higher incidence of serositis, pulmonary involvement and mortality. (Boddaert et al, 2004) It is difficult to find out the true prevalence of pulmonary complications of SLE since many cases are due to infections.…”

Section: Introductionmentioning

confidence: 99%