A longitudinal analysis of physical functional disability over the course of juvenile idiopathic arthritis

Magni‐Manzoni, Silvia; Pistorio, Angela; Labò, Elena; Viola, Stefania; Garcia-Munitis, Pablo; Panigada, Serena; Visconti, Chiara; Buoncompagni, Antonella; Martini, Alberto; Ravelli, Angelo

doi:10.1136/ard.2007.078121

Cited by 40 publications

(30 citation statements)

References 29 publications

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“…Patients with JIA with marked functional impairment have been found to have a greater risk of developing long-term physical disability21 and poorer Health-Related Quality of Life (HRQOL) 22. These findings suggest that early development of functional impairment represents an indication to the start of a more aggressive treatment with biological agents.…”

Section: Discussionmentioning

confidence: 99%

Predictors of poor response to methotrexate in polyarticular-course juvenile idiopathic arthritis: analysis of the PRINTO methotrexate trial

Vilca

Munitis

Pistorio

et al. 2010

Annals of the Rheumatic Diseases

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OBJECTIVES: To determine whether baseline demographic, clinical, articular and laboratory variables predict methotrexate (MTX) poor response in polyarticular-course juvenile idiopathic arthritis. METHODS: Patients newly treated for 6 months with MTX enrolled in the Paediatric Rheumatology International Trials Organization (PRINTO) MTX trial. Bivariate and logistic regression analyses were used to identify baseline predictors of poor response according to the American College of Rheumatology pediatric (ACR-ped) 30 and 70 criteria. RESULTS: In all, 405/563 (71.9%) of patients were women; median age at onset and disease duration were 4.3 and 1.4 years, respectively, with anti-nuclear antibody (ANA) detected in 259/537 (48.2%) patients. With multivariate logistic regression analysis, the most important determinants of ACR-ped 70 non-responders were: disease duration > 1.3 years (OR 1.93), ANA negativity (OR 1.77), Childhood Health Assessment Questionnaire (CHAQ) disability index > 1.125 (OR 1.65) and the presence of right and left wrist activity (OR 1.55). Predictors of ACR-ped 30 non-responders were: ANA negativity (OR 1.92), CHAQ disability index > 1.14 (OR 2.18) and a parent's evaluation of child's overall well-being < or = 4.69 (OR 2.2). CONCLUSION: The subgroup of patients with longer disease duration, ANA negativity, higher disability and presence of wrist activity were significantly associated with a poorer response to a 6-month MTX course. Results In all, 405/563 (71.9%) of patients were women; median age at onset and disease duration were 4.3 and 1.4 years, respectively, with anti-nuclear antibody (ANA) detected in 259/537 (48.2%) patients.

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Section: Discussionmentioning

confidence: 99%

Predictors of poor response to methotrexate in polyarticular-course juvenile idiopathic arthritis: analysis of the PRINTO methotrexate trial

Vilca

Munitis

Pistorio

et al. 2010

Annals of the Rheumatic Diseases

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“…The present classification distinguishes two categories of oligoarthritis based on the number of joints that are involved: persistent oligoarthritis in which the disease remains confined to four or less joints and extended oligoarthritis in which arthritis extend to more than four joints after the first 6 months of disease However, ANA positive patients belonging to these two categories share the same characteristics, strongly suggesting that they represent the same disease (Ravelli et al, 2005, 2011). Given the good prognosis a proportion of these children are treated with intra-articular steroids injections only (Ravelli et al, 2001; Ravelli and Martini, 2007; Magni-Manzoni et al, 2008; Solari et al, 2008). …”

Section: Current Jia Classification and Pathogenesismentioning

confidence: 99%

Current Medical Treatments for Juvenile Idiopathic Arthritis

Ruperto¹,

Martini²

2011

Front. Pharmacol.

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Juvenile idiopathic arthritis (JIA) differs markedly from adult rheumatoid arthritis. It is not a single disease, but an exclusion diagnosis that gather together all forms of arthritis that begin before the age of 16 years, persist for more than 6 weeks, and are of unknown origin. The advent of the new biological treatments has dramatically changed both the observed responses to treatment and the expectations of therapies. The implementation of an adequate legislation as well as the presence of international research networks of pediatric rheumatology have contributed to foster the conduct of controlled clinical trials and the development of validated outcome measures. This review will currently describe the methodological approach for performing clinical trials in JIA as well as the current available drug treatment.

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“…Как показано S. Magni-Manzoni и соавт. [35,36], ранний возраст дебюта в сочетании с множествен-ным поражением суставов значительно влиял на функцио-нальный прогноз, указывая на его ухудшение в будущем.…”

Section: нии ревматологии рамн москваunclassified

Functional Status and Quality of Life in Adult Patients With Juvenile Arthritis During the Long-Termcourse of Disease

Салугина¹

2011

Modern Rheumatology Journal

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Цель -оценить функциональный статус и качество жизни взрослых пациентов, длительно страдающих ювенильным артритом (ЮА HAQ (R=0,6, p<0,001), возрастом больных (R=0,3, p<0,001),3, p<0,001 43.3, 39.8, and 16.9% of the patients, respectively. There was a correlation between the health status and the HAQ scores (R = 0.6; p<0,001), age (R = 0.3; p<0,001), and JA duration (R = 0.3; p<0.001

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A longitudinal analysis of physical functional disability over the course of juvenile idiopathic arthritis

Abstract: A wide within-patient and between-patient variability in the longitudinal course of functional disability was found. Children with early disease onset and a greater number of restricted joints had the highest risk of developing long-term physical disability.

Cited by 40 publications

References 29 publications

Predictors of poor response to methotrexate in polyarticular-course juvenile idiopathic arthritis: analysis of the PRINTO methotrexate trial

Predictors of poor response to methotrexate in polyarticular-course juvenile idiopathic arthritis: analysis of the PRINTO methotrexate trial

Current Medical Treatments for Juvenile Idiopathic Arthritis

Functional Status and Quality of Life in Adult Patients With Juvenile Arthritis During the Long-Termcourse of Disease

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