A longitudinal event-related potential study of selective serotonin reuptake inhibitor therapy in treatment-naïve pediatric obsessive compulsive disorder patients

Yamamuro, Kazuhiko; Ota, Toyosaku; Iida, Junzo; Kishimoto, Naoki; Nakanishi, Yoko; Matsuura, Hiroki; Uratani, Mitsuhiro; Okazaki, Kosuke; Kishimoto, Toshifumi

doi:10.1016/j.psychres.2016.07.031

Cited by 7 publications

(19 citation statements)

References 62 publications

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“…Studies of auditory MMN in individuals with ADHD have generally shown decreased MMN amplitudes as compared to TD controls, with subsequent increase in MMN amplitude after administration of stimulants (Sawada et al, 2010; M. J. Taylor, Voros, Logan, & Malone, 1993; Yamamuro et al, 2016] or atomoxetine [Yamamuro et al, 2016]. Similar augmentation of MMN has been described with SSRIs [Wienberg, Glenthoj, Jensen, & Oranje, 2010; Yamamuro et al, 2016]. Benzodiazepines and antiepileptics may suppress MMN [Rosburg et al, 2005; Rosburg, Marinou, Haueisen, Smesny, & Sauer, 2004].…”

Section: Discussionmentioning

confidence: 86%

Individuals With Autism Have No Detectable Deficit in Neural Markers of Prediction Error When Presented With Auditory Rhythms of Varied Temporal Complexity

et al. 2020

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The brain's ability to encode temporal patterns and predict upcoming events is critical for speech perception and other aspects of social communication. Deficits in predictive coding may contribute to difficulties with social communication and overreliance on repetitive predictable environments in individuals with autism spectrum disorder (ASD). Using a mismatch negativity (MMN) task involving rhythmic tone sequences of varying complexity, we tested the hypotheses that (1) individuals with ASD have reduced MMN response to auditory stimuli that deviate in presentation timing from expected patterns, particularly as pattern complexity increases and (2) amplitude of MMN signal is inversely correlated with level of impairment in social communication and repetitive behaviors. Electroencephalography was acquired as individuals (age 6-21 years) listened to repeated five-rhythm tones that varied in the Shannon entropy of the rhythm across three conditions (zero, medium-1 bit, and high-2 bit entropy). The majority of the tones conformed to the established rhythm (standard tones); occasionally the fourth tone was temporally shifted relative to its expected time of occurrence (deviant tones). Social communication and repetitive behaviors were measured using the Social Responsiveness Scale and Repetitive Behavior Scale-Revised. Both neurotypical controls (n = 19) and individuals with ASD (n = 21) show stepwise decreases in MMN as a function of increasing entropy. Contrary to the result forecasted by a predictive coding hypothesis, individuals with ASD do not differ from controls in these neural mechanisms of prediction error to auditory rhythms of varied temporal complexity, and there is no relationship between these signals and social communication or repetitive behavior measures.

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Section: Discussionmentioning

confidence: 86%

Individuals With Autism Have No Detectable Deficit in Neural Markers of Prediction Error When Presented With Auditory Rhythms of Varied Temporal Complexity

et al. 2020

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“…MMN was identified from the difference waveform as a negative wave with a peak latency between 100 and 250 ms, and its latency and amplitude were recorded. We have previously reported similar methods for examining ERPs in several psychiatric disorders 18,19…”

Section: Methodsmentioning

confidence: 99%

Effects of Canon chord progression on brain activity and motivation are dependent on subjective feelings, not the chord progression per se

Kayashima¹,

Yamamuro²,

Makinodan³

et al. 2017

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Abstract:A number of studies have indicated that relaxing and pleasant melodies are useful for the treatment of patients with psychiatric disorders, including schizophrenia, depression, and dementia. However, few studies have investigated what constitutive elements of the music had an effect on brain activity. As Canon chord progression is one of critical elements for pleasant melodies, we sought to examine the effects of Canon chord progression and pitch-shifted Canon chord progression on brain activity using performance on the auditory oddball task during event-related potentials (ERPs) in 30 healthy subjects. Unexpectedly, we found no differences in ERP components between subjects listening to Canon chord progression (n=15) or pitchshifted Canon chord progression (n=15). Next, we divided participants into two groups: those who found the melody pleasant (n=17) and those who did not (n=13), for both Canon chord progression and pitch-shifted Canon chord progression. The average of P300 amplitude was higher at Fz in subjects found the music pleasant versus those finding it unpleasant. Moreover, subjects who found it pleasant exhibited higher motivation scores than those who felt it was unpleasant, whereas listening to Canon chord progression did not matter. These findings suggest that the effects of Canon chord progression on brain activity and motivation depend on subjective feelings, not the chord progression per se.

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“…The finding of attenuated P300 amplitude has also been considered to be a pattern of genetic endophenotype in OCD (75,76), which has also been confirmed in pediatric studies (64,68,70). Moreover, it was found to correlate with illness severity, suggesting that the reduction in P300 amplitude may be a sensitive tool for measuring some biological aspects of OCD severity (64,68), also based on the evidence that P300 is generated along a widely distributed network that includes several brain areas implicated in the pathophysiology of OCD (12)(13)(14)(15)(16)(17)(18)26). Of note, one study in schizo-OCD patients showed a pattern of alteration, i.e., a reduced P300 amplitude as in schizophrenia (60), which suggests the occurrence of brain structural abnormalities also in this peculiar clinical psychosis with relevant obsessional symptoms (88)(89)(90).…”

Section: Discussionmentioning

confidence: 69%

“…A significant relationship between ERP abnormalities and severity of OCD symptoms was found in 13 studies ( 44 , 46 – 53 , 55 , 57 , 59 , 64 , 68 – 70 , 72 ). Thus, ERP abnormalities might be considered as a sensitive tool for measuring the biological substrate of OCD severity.…”

Section: Resultsmentioning

confidence: 90%

“…Overall, studies reporting a P300 amplitude reduction in OCD are thirteen ( 20 , 28 , 45 , 51 , 54 , 55 , 59 , 64 , 65 , 67 , 68 , 70 , 72 ), including the result of a P300 alteration at the F7 location in patients with functional constipation within a probable OCD ( 65 ). Conversely, we counted eight studies reporting enhanced P300 amplitude in OCD patients compared to normal controls ( 50 , 52 , 58 , 61 – 63 , 66 , 69 ), a finding that was considered as an electrophysiological correlate of an OCD trait and indicating an increased propensity to be aroused ( 50 , 77 ).…”

Section: Resultsmentioning

confidence: 99%

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A Review on P300 in Obsessive-Compulsive Disorder

2021

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Neuropsychological studies indicate the presence of cognitive changes in patients with obsessive-compulsive disorder (OCD). Indeed, OCD may be included among the dysfunctions of the frontal lobes and their connections with the limbic system, associative cortex, and basal ganglia. P300 is a positive component of the human event-related potential (ERP); it is associated with processes of encoding, identification, and categorization constituting, as a whole, the superior cortical function of information processing. Thus, P300 explores several areas that are implicated in OCD pathophysiology. Our aim is to review all relevant studies on the P300 component of the human ERP in order to recognize any significant central nervous system (CNS) correlate of cognitive dysfunction in OCD. A PubMed-based literature search resulted in 35 articles assessing P300 in OCD and reporting neurophysiological correlates of response inhibition, cortical hyperarousal, and over-focused attention. A decreased P300 amplitude was reported in both adult and pediatric patients, with a trend toward normalization after pharmacological treatment. Source localization studies disclosed an association between P300 abnormalities and the functioning of brain regions involved in the pathophysiology of OCD. Moreover, studies converge on the evidence of neurophysiological dysfunction in the frontal areas with impairment of the normal inhibitory processes in OCD. At least some of these electrophysiological correlates might reflect the obsessive thoughts and compulsions that characterize this disorder. These findings may also support cognitive-behavioral therapy (CBT) approaches on over-focused attention and inflexibility of compulsive behaviors, which should be associated to pharmacological treatment in these patients.

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A longitudinal event-related potential study of selective serotonin reuptake inhibitor therapy in treatment-naïve pediatric obsessive compulsive disorder patients

Cited by 7 publications

References 62 publications

Individuals With Autism Have No Detectable Deficit in Neural Markers of Prediction Error When Presented With Auditory Rhythms of Varied Temporal Complexity

Individuals With Autism Have No Detectable Deficit in Neural Markers of Prediction Error When Presented With Auditory Rhythms of Varied Temporal Complexity

Effects of Canon chord progression on brain activity and motivation are dependent on subjective feelings, not the chord progression per se

A Review on P300 in Obsessive-Compulsive Disorder

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