A longitudinal pilot study to assess temporal changes in coronary arterial 18F-sodium fluoride uptake

Kitagawa, Toshiro; Sasaki, Ko; Fujii, Yoshiaki; Tatsugami, Fuminari; Awai, Kazuo; Hirokawa, Yutaka; Nakano, Yukiko

doi:10.1007/s12350-022-02975-w

Cited by 3 publications

(6 citation statements)

References 12 publications

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“…Forty-five articles were included in this review [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ] ( Figure 1 ), to which were added selected articles on methodological and other aspects. Findings in the articles are summarized in the following sections and in Tables S1–S6 in the Supplementary Material .…”

Section: Resultsmentioning

confidence: 99%

“…Anti-atherosclerotic intervention evaluated by NaF-PET/CT [ 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ].…”

Section: Resultsmentioning

confidence: 99%

“…Several studies dealt with one arterial bed only, i.e., coronary arteries [ 16 , 17 , 18 , 20 , 29 , 30 , 31 , 38 , 39 , 44 ], global heart [ 22 , 23 , 24 , 25 , 27 , 34 ], pulmonary arteries [ 11 ], left carotid artery [ 28 ], aorta [ 26 , 32 , 41 , 42 , 48 , 49 ], abdominal aorta [ 13 , 33 , 45 ], or several arterial beds [ 5 , 6 , 7 , 8 , 9 , 10 , 12 , 14 , 15 , 21 , 35 , 36 , 37 , 40 , 41 , 43 , 46 , 47 ]. Eight reports were experimental animal studies [ 5 , 6 , 32 , 42 , 43 , 45 , 48 , 49 ], and one was an image case report [ 44 <...…”

Section: Resultsmentioning

confidence: 99%

“…Kitagawa et al [ 38 ] found no mean change in NaF uptake in 51 coronary lesions of 15 patients imaged twice 37–59 months apart. Baseline CT-based lesion feature (location, obstruction, plaque type, high-risk features) in individual patients did not correlate with change in NaF uptake, but 63% of NaF positive lesions at baseline were also positive at follow-up.…”

Section: Resultsmentioning

confidence: 99%

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NaF-PET Imaging of Atherosclerosis Burden

et al. 2023

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The method of 18F-sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) of atherosclerosis was introduced 12 years ago. This approach is particularly interesting because it demonstrates microcalcification as an incipient sign of atherosclerosis before the development of arterial wall macrocalcification detectable by CT. However, this method has not yet found its place in the clinical routine. The more exact association between NaF uptake and future arterial calcification is not fully understood, and it remains unclear to what extent NaF-PET may replace or significantly improve clinical cardiovascular risk scoring. The first 10 years of publications in the field were characterized by heterogeneity at multiple levels, and it is not clear how the method may contribute to triage and management of patients with atherosclerosis, including monitoring effects of anti-atherosclerosis intervention. The present review summarizes findings from the recent 2¾ years including the ability of NaF-PET imaging to assess disease progress and evaluate response to treatment. Despite valuable new information, pertinent questions remain unanswered, not least due to a pronounced lack of standardization within the field and of well-designed long-term studies illuminating the natural history of atherosclerosis and effects of intervention.

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Section: Resultsmentioning

confidence: 99%

“…Anti-atherosclerotic intervention evaluated by NaF-PET/CT [ 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ].…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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NaF-PET Imaging of Atherosclerosis Burden

et al. 2023

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“…Imaging atherosclerosis with new and novel PET radiotracers and evaluating its association with stroke and multi-vessel coronary artery disease can help elucidate the basic mechanisms of atherosclerosis (16)(17)(18)(19)(20). In addition, the reproducibility and in vivo imaging can be useful in the longitudinal follow-up of disease status (21). Another increasingly popular imaging modality, cardiovascular magnetic resonance (CMR), provides comprehensive information without the need for radiation, and it has recently been used to evaluate the etiology and predict the outcomes of cardiovascular diseases (22,23).…”

Section: Editorial On the Research Topic Atherosclerosis And Function...mentioning

confidence: 99%