A longitudinal study of cortical auditory maturation and implications of the short inter-implant delay in children with bilateral sequential cochlear implants

Atilgan, Atılım; Cesur, Sıdıka; Çiprut, Ayça

doi:10.1016/j.ijporl.2023.111472

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…The LLR has also been studied in the context of binaural hearing [ 39 ]. Meanwhile, studies have shown that the LLR is modulated by binaural cues, including interaural time and intensity differences, and is sensitive to the spatial location of sounds [ 40 ], suggesting its potential role in auditory scene analysis through its sensitivity to changes in binaural cues over time [ 41 ]. However, the literature on the LLR in binaural hearing is still limited, demanding further research to fully understand its contribution to binaural processing.…”

Section: Introductionmentioning

confidence: 99%

Frequency and Time Domain Analysis of EEG Based Auditory Evoked Potentials to Detect Binaural Hearing in Noise

Ignatious

Azam

Jonkman

et al. 2023

JCM

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Hearing loss is a prevalent health issue that affects individuals worldwide. Binaural hearing refers to the ability to integrate information received simultaneously from both ears, allowing individuals to identify, locate, and separate sound sources. Auditory evoked potentials (AEPs) refer to the electrical responses that are generated within any part of the auditory system in response to auditory stimuli presented externally. Electroencephalography (EEG) is a non-invasive technology used for the monitoring of AEPs. This research aims to investigate the use of audiometric EEGs as an objective method to detect specific features of binaural hearing with frequency and time domain analysis techniques. Thirty-five subjects with normal hearing and a mean age of 27.35 participated in the research. The stimuli used in the current study were designed to investigate the impact of binaural phase shifts of the auditory stimuli in the presence of noise. The frequency domain and time domain analyses provided statistically significant and promising novel findings. The study utilized Blackman windowed 18 ms and 48 ms pure tones as stimuli, embedded in noise maskers, of frequencies 125 Hz, 250 Hz, 500 Hz, 750 Hz, 1000 Hz in homophasic (the same phase in both ears) and antiphasic (180-degree phase difference between the two ears) conditions. The study focuses on the effect of phase reversal of auditory stimuli in noise of the middle latency response (MLR) and late latency response (LLR) regions of the AEPs. The frequency domain analysis revealed a significant difference in the frequency bands of 20 to 25 Hz and 25 to 30 Hz when elicited by antiphasic and homophasic stimuli of 500 Hz for MLRs and 500 Hz and 250 Hz for LLRs. The time domain analysis identified the Na peak of the MLR for 500 Hz, the N1 peak of the LLR for 500 Hz stimuli and the P300 peak of the LLR for 250 Hz as significant potential markers in detecting binaural processing in the brain.

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Section: Introductionmentioning

confidence: 99%

Frequency and Time Domain Analysis of EEG Based Auditory Evoked Potentials to Detect Binaural Hearing in Noise

Ignatious

Azam

Jonkman

et al. 2023

JCM

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Validation of direct recording of electrically evoked cortical auditory evoked potentials through a cochlear implant system

Bell-Souder,

Chen,

Spahr

et al. 2024

Sci Rep

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Cochlear implants (CI) are one of the most successful treatments available to enable individuals with severe to profound hearing loss to regain access to the world of sound. This is accomplished through the electrical stimulation of the auditory nerve using electrodes implanted inside the cochlea. The use of subjective user feedback makes the process of fitting these devices much more challenging in cases where users are not able to actively or accurately report their experience (e.g. pediatrics), making an objective measurement that reflects the accuracy or effectiveness of a program quite attractive. We recorded one objective measure, the electrically-stimulated cortical auditory evoked potential (eCAEP), non-invasively using the CI in response to a simulated speech sound in seven adult participants and compared it to their eCAEP recorded using a scalp EEG set-up. The eCAEPs recorded with CI electrodes were comparable to scalp recorded eCAEPs (grand mean cross-correlation of r = 0.83, individual mean cross-correlations ranged from 0.13 to 0.70). Evoked potential peaks P1, N1 and P2 showed no significant latency difference based on if the eCAEP was recorded on the scalp or using the CI. The eCAEP waveforms recorded via the CI appear to converge in a distinct P1-N1-P2 waveform by as early as 130 sweeps. In conclusion, in this study we show the feasibility of recording the eCAEP directly through the CI system, which could potentially be used to guide CI fitting and track auditory cortex development in response to CI use.

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Person-centered aural rehabilitation program improved mood, cognition, and auditory processing in a professional musician who uses a hearing aid and cochlear implant: Case Report

Brennan,

Spence-Olson,

Cormier

et al. 2024

Front. Rehabil. Sci.

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IntroductionAural rehabilitation focused on music for individuals with cochlear implants (CIs) and/or hearing aids (HAs) typically emphasizes perceptual skills rather than enjoyment of music. Yet, those with CIs and/or HAs often struggle to enjoy music, complaining that it sounds distorted with the implant or HAs. Typically, aural rehabilitation programs require a significant time commitment, but this may not be feasible or preferable for many patients. This study aimed to evaluate the efficacy of two individualized intensive 3-week home practice programs focused on enjoyment of music, a personal goal for this subject.MethodsThe subject was a professional musician who used a CI and HA. Cognitive measures of global cognitive function, executive function, processing speed, auditory working memory, visual-spatial abilities, verbal fluency, and auditory-verbal memory, as well as auditory electrophysiology (EEG) measures were conducted pre-post experiment 2. Two experiments were undertaken to evaluate responses to two practice programs that incorporated different variations in listening dosage and intervention activities.ResultsExperiment 1 resulted in minimal measurable improvements related to music likability ratings, with the highest dosage condition showing a small increase in average likability rating from baseline to week 3. The results of experiment 2 revealed an improvement in likability ratings only when dosage steadily increased each week. The subject also reported improved mood and decreased frustration during weeks two and three of experiment 2. Finally, we found improvement pre-post experiment 2 on several cognitive and EEG measures.DiscussionThe results of these experiments are encouraging and support the use of an individualized, person-centered, and semi-structured home practice program to increase music enjoyment and improve quality of life and auditory processing for individuals with hearing loss. Future studies should aim to increase sample size and explore pairing person-centered home practice programs with concurrent clinician-lead aural rehabilitation.

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A longitudinal study of cortical auditory maturation and implications of the short inter-implant delay in children with bilateral sequential cochlear implants

Cited by 3 publications

References 26 publications

Frequency and Time Domain Analysis of EEG Based Auditory Evoked Potentials to Detect Binaural Hearing in Noise

Frequency and Time Domain Analysis of EEG Based Auditory Evoked Potentials to Detect Binaural Hearing in Noise

Validation of direct recording of electrically evoked cortical auditory evoked potentials through a cochlear implant system

Person-centered aural rehabilitation program improved mood, cognition, and auditory processing in a professional musician who uses a hearing aid and cochlear implant: Case Report

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