A Longitudinal Study of Oxidative Stress and Antioxidant Status in Women With Uncomplicated Pregnancies Throughout Gestation

Hung, Tai-Ho; Lo, Lun Jou; Chiu, Tsung‐Hong; Li, Meng-Jen; Yeh, Yi-Lin; Chen, Szu-Fu; Hsieh, T’sang‐T’ang

doi:10.1177/1933719109359704

Cited by 110 publications

(79 citation statements)

References 38 publications

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“…Data from these independent cohorts suggest a 40% increase in 8-iso-PGF 2α levels at the end of pregnancy. However, it was previously shown that plasma 8-iso-PGF 2α levels are significantly increased by about two-fold from 15-20 weeks to the 37-41 weeks of pregnancy [52]. In the present study, levels of the various F 2 -isoPs varied from 0 (iPF 2α -IV) to 2.4-fold (iPF 2α -VI + 5-iPF 2α -VI) at the end of pregnancy compared to early pregnancy.…”

Section: Discussionmentioning

confidence: 61%

F2-isoprostanes are correlated with trans fatty acids in the plasma of pregnant women

LaRose¹,

Julien

Fraser

et al. 2014

Prostaglandins, Leukotrienes and Essential Fatty Acids

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We hypothesized that the mild physiological oxidative stress present during pregnancy could increase both, plasma F 2 -isoprostanes (F 2 -isoPs) by lipid oxidation and trans fatty acids (TFA) through cis-trans isomerization respectively. Plasma samples collected at 12-18 weeks (MIROS cohort; n=65) and 38-41 weeks of pregnancy (CHUL cohort; n = 21) were subjected to alkaline hydrolysis followed by liquid-liquid extraction in order to extract total F 2 -isoPs for quantification by HPLC-MS/MS. Several positive correlations were found between F 2 -isoPs and TFA, measured by GC-FID in plasma phospholipids, such as 6t-18:1, 9t-18:1 and 9t,12c-18:2 (r > 0.306; p < 0.045). Despite its low level, the 9t,12c-18:2 trans isomer, known to be associated to cardiovascular diseases, showed the most significant correlations with F 2 -isoPs. No correlation was observed between F 2 -isoPs and 9t-16:1 or 11t-18:1. In summary, this study suggests either a concomitant phenomenon or a competition between lipid peroxidation and cis-trans isomerisation of the cis precursor fatty acid in vivo during pregnancy.

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Section: Discussionmentioning

confidence: 61%

F2-isoprostanes are correlated with trans fatty acids in the plasma of pregnant women

LaRose¹,

Julien

Fraser

et al. 2014

Prostaglandins, Leukotrienes and Essential Fatty Acids

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“…Another cause of deficiency of these antioxidants during pregnancy could be placental transfer. Significant changes in the antioxidant enzyme activities have also been observed in pregnant females (Watson et al 1997, Djordjevic et al 2004, Jauniaux et al 2005, Oztabak et al 2005, Erisir et al 2009, Hung et al 2010.…”

Section: Discussionmentioning

confidence: 91%

“…As pregnancy and fetal growth progress, an overproduction of ROS in placental and fetal mitochondria is observed (Kim et al 2005). It is thought that the placenta is a major source of oxidative stress in pregnant females (Gitto et al 2002, Myatt and Cui 2004, Hung et al 2010. A significant part of the total indicators of pregnancy-related oxidative stress may derive from the placenta's mitochondrial mass, which increases with gestational age (Wang and Walsh 1998).…”

Section: Discussionmentioning

confidence: 99%

“…Numerous studies have demonstrated higher concentrations of lipid peroxidation products in healthy pregnant women than in non-pregnant women (Uotila et al 1991, Qanungo et al 2000, Toescu at al 2002, Djordjevic et al 2004, Hung et al 2010, Idonije et al 2011. Some authors have found that plasma concentrations of TBARS and other markers of lipid peroxidation gradually increase during pregnancy, reaching the highest values in the third trimester (Carine et al 1993, Djordjevic et al 2004, Hung et al 2010), but other authors have reported that levels of the products of lipid peroxidation reach their maximum concentrations in the second trimester and then decline until term (Uotila et al 1991, Qanungo et al 2000. Also, a comparison of the levels of the markers of protein peroxidation processes in women indicates the occurrence of oxidative stress during pregnancy (Wisdom et al 1991).…”

Section: Discussionmentioning

confidence: 99%

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Assessment of lipid and protein peroxidation markers in non-pregnant and pregnant female dogs

Szczubiał¹,

Kankofer²,

Dąbrowski³

et al. 2015

Polish Journal of Veterinary Sciences

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The aim of the study was to investigate oxidative stress during normal pregnancy in female dogs based on an evaluation of plasma markers for lipid and protein peroxidation. Twenty clinically healthy female dogs (10 non-pregnant and 10 pregnant) were used in the study. Blood samples from the pregnant animals were collected at 19-21, 38-40, and 56-58 days of pregnancy. Blood samples from non-pregnant female dogs were obtained between 20 and 35 days after ineffective breeding. As indicators of oxidative stress, we measured the following using spectrophotometric and spectrofluorimetric methods: thiobarbituric acid reactive substances (TBARS), radical cations of N,N, diethylpara-phenylene diamine (RC-DEPPD), sulfhydryl groups (SH groups), bityrosine and formylkynurenine. The mean plasma TBARS concentration in the pregnant dogs (0.486 ± 0.071 -0.581 ± 0.191 μmol/g protein) was significantly higher (p<0.05) than that found in the non-pregnant animals (0.274 ± 0.111 μmol/g protein). A marked, although not significant, decrease in SH group content, as well as an increase in bityrosine and formylkynurenine concentration were concurrently observed in the pregnant dogs. No significant differences were found in terms of the studied markers in the pregnant animals when comparing the values obtained during the investigated periods of pregnancy, although there was a progressive decrease in TBARS concentration and a progressive increase in RC-DEPPD, bityrosine and formylkynurenine contents. Our findings suggest that normal pregnancy in female dogs is associated with oxidative stress. Further studies are necessary to establish the physiological ranges of antioxidative/oxidative profiles in pregnant dogs and to explain if and how the intensity of oxidative stress might contribute to the risk of the complications of pregnancy.

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“…After the first trimester of pregnancy, the formation and development of placental blood flow results in a rapid increase in partial oxygen pressure (1,2). Increased metabolic activity and reduced antioxidative activity in uncomplicated pregnancy may lead to exaggerated oxidative stress (OS) (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Lipid-lysine adducts and modified tyrosines as markers of oxidative stress in the second trimester of pregnancy and their association with infant characteristics

Rejc

Kato

Karas-Kuzelicki

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Pregnancy is a physiological state accompanied by excessive levels of oxidative stress (OS), due to the increased demand and utilisation of oxygen. There is increasing evidence that maternally augmented OS exerts an adverse effect on pregnancy outcome. The aim of the present prospective study was to determine the association between the urinary concentration of relatively novel OS markers measured in the second trimester of pregnancy and the infant characteristics at birth. The maternal levels of urinary hexanoyl-lysine (HEL), propanoyl-lysine (PRL), dityrosine (DiY) and 3-nitrotyrosine (NY) were evaluated in generally healthy pregnant subjects to determine their association with birth weight, gestation at delivery and Apgar score. The observed levels of the markers were in agreement with those measured in healthy non-pregnant subjects in a previous study. A positive correlation was detected between HEL and PRL, as well as between HEL and DiY. Although the absence of a correlation between NY and the other markers has been previously noted in a non-pregnant population, a positive correlation in the pair PRL-NY (r=0.367; P<0.001) was observed in the present study. Maternal cigarette smoking was associated with increased urinary PRL levels (P=0.034). The most notable observation in the present study was that high levels of PRL and NY were associated with low Apgar scores at 1 and 5 min after birth (OR, 1.098 and 2.084 for PRL and NY, respectively; P<0.05). However, poor predictive accuracy was shown. For NY, the following results were obtained: Area under the curve (AUC), 0.818; sensitivity, 100%; specificity, 57%; positive predictive value (PPV), 11.54%; and negative predictive value (NPV), 100%.For PLR the values were as follows: AUC, 0.802; sensitivity, 100%; specificity, 62.6%; PPV, 13.05%; and NPV, 100%. DiY was negatively associated with preterm birth risk (OR=0.703; P=0.028). In conclusion, the results of the present study indicated the presence of OS in the second trimester of pregnancy, which was detected with damage to lipids and proteins and associated with an adverse Apgar score; however, the selected urinary markers exhibited poor positive predictive efficacy.

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A Longitudinal Study of Oxidative Stress and Antioxidant Status in Women With Uncomplicated Pregnancies Throughout Gestation

Cited by 110 publications

References 38 publications

F2-isoprostanes are correlated with trans fatty acids in the plasma of pregnant women

F2-isoprostanes are correlated with trans fatty acids in the plasma of pregnant women

Assessment of lipid and protein peroxidation markers in non-pregnant and pregnant female dogs

Lipid-lysine adducts and modified tyrosines as markers of oxidative stress in the second trimester of pregnancy and their association with infant characteristics

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