A Longitudinal Study on Avian Polyomavirus-specific Antibodies in Captive Spix's Macaws (Cyanopsitta spixii)

Deb, A; Foldenauer, Ulrike; Borjal, R J; Streich, W. Jürgen; Lüken, Caroline; Johne, Reimar; Müller, Hermann; Hammer, Sven

doi:10.1647/2009-004.1

Cited by 8 publications

(5 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In summary, the results of our study presented here and of previous investigations may indicate that the four polyomaviruses of birds could be classified into two different serogroups. Interpretation of results obtained with serological tests for polyomavirus infection of birds, which are in use for APyV and GHPyV (Khan et al , 2000; Zielonka et al , 2006; Deb et al , 2010), should take these cross-reactions into consideration. The demonstration of cross-HI activities, as well as cross-neutralization activities of the rabbit sera directed against individual virus types, may indicate protective effects after immunization with VLPs.…”

Section: Discussionmentioning

confidence: 99%

Serological cross-reactions between four polyomaviruses of birds using virus-like particles expressed in yeast

Zielonka

Gedvilaitė

Reetz

et al. 2012

Journal of General Virology

Self Cite

View full text Add to dashboard Cite

Polyomaviruses are aetiological agents of fatal acute diseases in various bird species. Genomic analysis revealed that avian polyomavirus (APyV), crow polyomavirus (CPyV), finch polyomavirus (FPyV) and goose hemorrhagic polyomavirus (GHPyV) are closely related to each other, but nevertheless form separate viral species; however, their serological relationship was previously unknown. As only APyV can be grown efficiently in tissue culture, virus-like particles (VLPs) were generated by expression of the genomic regions encoding the major structural protein VP1 of these viruses in yeast; these were used to elicit type-specific antibodies in rabbits and as antigens in serological reactions. For increased VLP assembly, a nuclear-localization signal was introduced into APyV-VP1. VLPs derived from the VP1 of the monkey polyomavirus simian virus 40 served as control. APyV-, GHPyV-and CPyV-VLPs showed haemagglutinating activity with chicken and human erythrocytes. CPyV-and GHPyV-specific sera showed slight cross-reactions in immunoblotting, haemagglutination-inhibition assay and indirect ELISA. The FPyV-specific serum inhibited the haemagglutination activity of APyV-VLPs slightly and showed a weak crossneutralizing activity against APyV in cell-culture tests. Generally, these data indicate that the four polyomaviruses of birds are serologically distinct. However, in accordance with genetic data, a relationship between CPyV and GHPyV as well as between APyV and FPyV is evident, and grouping into two different serogroups may be suggested. The haemagglutinating activity of APyV, CPyV and GHPyV may indicate similar receptor-binding mechanisms for these viruses. Our data could be useful for the development of vaccines against the polyomavirus-induced diseases in birds and for interpretation of diagnostic test results.

show abstract

Section: Discussionmentioning

confidence: 99%

Serological cross-reactions between four polyomaviruses of birds using virus-like particles expressed in yeast

Zielonka

Gedvilaitė

Reetz

et al. 2012

Journal of General Virology

Self Cite

View full text Add to dashboard Cite

show abstract

“…The majority of adult humans have antibodies to all thirteen identified human polyomaviruses 2,4–6 . Very little has been published regarding seroprevalence of naturally occurring polyomaviruses in animals, though one long-term study demonstrated high seroprevalence of avian polyomavirus in psittacines 7 . We hypothesize that exposure to RacPyV mirrors that of human polyomavirus, with geographically widespread seroprevalence not restricted to areas where tumors have been identified.…”

Section: Introductionmentioning

confidence: 99%

Exposure to raccoon polyomavirus (RacPyV) in free-ranging North American raccoons (Procyon lotor)

et al. 2016

View full text Add to dashboard Cite

There is evidence that raccoon polyomavirus is causative for neuroglial brain tumors in the western United States. It is unknown if infection is limited to geographic locales where tumors have been reported or is widespread, like human polyomaviruses. We demonstrate raccoons in western, eastern and midwestern states have been exposed to RacPyV by detection of antibodies to capsid protein, VP1. While raccoons in eastern and midwestern states are seropositive, exposure is lower than in the western states. Additionally, across geographic areas seropositivity is higher in older compared to younger raccoons, similar to polyomavirus exposure in humans. Serum titers are significantly higher in raccoons with tumors compared to raccoons without. Unlike polyomavirus-associated diseases in humans, we did not detect significant sequence variation between tumor and non-tumor tissue in raccoons with tumors compared to those without tumors. This warrants further investigation into co-morbid diseases or genetic susceptibility studies of the host.

show abstract

“…Apesar da distribuição mundial do vírus (ENDERS et al, 1997;PHALEN et al, 2000;BERT et al, 2005;WOLFF et al, 2006;DEB et al, 2010;ZHUANG et al, 2012;ALLEY et al, 2013;BENNETT;GILLETT, 2014), pouco se estudou sobre ele no Brasil (PHILADELPHO et al, 2015). O APV é comumente descrito em psitacídeos, entretanto, pode ocorrer em passeriformes também (GARCIA et al, 1993;ALLEY et al, 2013), apesar de ser menos descrito.…”

Section: Introdução 1 Introdução Geralunclassified

“…Os sinais clínicos podem variar de acordo com a estirpe viral, ocorrendo a forma crônica na Europa e aguda na América (GERLACH, 1994;RITCHIE, 1995). O vírus está distribuído mundialmente (ENDERS et al, 1997;PHALEN et al, 2000;BERT et al, 2005;WOLFF et al, 2006;DEB et al, 2010;ZHUANG et al, 2012;ALLEY et al, 2013;BENNETT;GILLETT, 2014) e leva a uma elevada mortalidade, sendo causador de perdas econômicas anuais substanciais para a avicultura pet (PHALEN, 1998).…”

Section: Introductionunclassified

<b>Caracterização molecular de bornavírus, poliomavírus e circovírus em aves de cativeiro, vida livre e criação comercial</b>

Azevedo¹

View full text Add to dashboard Cite

AGRADECIMENTOSInicio os agradecimentos com a minha família: a meus pais: Maria de Jesus Garcia Philadelpho Azevedo e Philadelpho Azevedo Neto; ao meu irmão, Felipe Philadelpho Azevedo e a minha cunhada, Carla Linhares. Por estarem sempre presente e incentivando, por cederem os ouvidos todas as vezes que precisei desabafar, por acreditarem em mim mesmo quando eu mesmo não acreditava. Amo vocês.Ao meu namorado, Sahelê Montoza de Oliveira Felício, companheiro de todas as horas, por todo o carinho e compreensão.Não poderia deixar de agradecer também a minha segunda família, Luís Faria, Olga Penalva, Guilherme Penalva, Renata Penalva e Maria do Carmo. Por me fazerem sentir em casa em São Paulo, pela acolhida, pelo apoio e amor incondicional.Ao meu orientador, Prof. Dr. Antonio José Piantino Ferreira, por me orientar e me apoiar e pela sua disponibilidade e a Prof. Dr. Claudete S. A. Ferreira, que juntos formam uma outra família que me acolheu com muito carinho.Ao Dennis Rubbenstroth, pela disponibilidade e por oferecer seu conhecimento, ajudando na análise dos dados durante este trabalho. Sua parceria foi muito importante.A FMVZ USP e ao VPT por me darem essa oportunidade de enriquecer meu conhecimento.A Marta Brito Guimarães, que além de ceder parte do material utilizado neste projeto, sempre foi uma mentora e grande amiga.A Yamê Miniero Davies e Luciana Allegretti Frazão pela ajuda no laboratório, por animar todo lugar que passam e pela amizade, que levarei para a vida toda.Aos meus amigos Marcos P. V. Cunha, Gabriela Oliveira, Mirela Vilela, Dennis Zanatto, Claudia Carranza, Luis Nunes e Silvana Santander pelo companheirismo.A University of Saskatchewan pela oportunidade de intercâmbio.A meus amigos que fiz no Canadá, que tornaram esta experiência ainda mais especial: Tatiana Natasha, Alexandra Belota, Eduardo Bacchi, Amanda Nascimento, Carolina Malgarin, Tábata Bagatim, Craig Baird, Carolina topan, Shelly Popowich, Ashish Gupta.Aos membros da Banca Examinadora, por terem atendido ao convite e dispor de tempo e conhecimento para analisar este trabalho.A Milena Francisco de Oliveira, sempre com bom humor ajudando com as burocracias da pós-graduação. Muito obrigada, você é parte essencial da vida de todos nós.A CAPES pelo apoio financeiro.A todos que participaram direta ou indiretamente neste projeto."A mente que se abre a uma nova ideia jamais voltará ao seu tamanho original" Albert Eistein As doenças virais são de extrema importância para a saúde das aves. Os vírus podem se espalhar através de fezes, secreções respiratórias ou exfoliação epitelial de penas e pele, dificultando ainda mais esse controle. A utilização do PCR permite detecção de pequenas concentrações do vírus além da possibilidade de diagnosticar a patologia antes de iniciar alterações histológicas. O bornavírus aviário é responsável pela doença da dilatação pró-ventricular (PDD) em psitacídeos e outras aves, uma doença neurológica letal, que foi descoberta no início da década de oitenta na Europa e América do Norte. A detecção do vírus em passerifor...

show abstract

A Longitudinal Study on Avian Polyomavirus-specific Antibodies in Captive Spix's Macaws (Cyanopsitta spixii)

Cited by 8 publications

References 25 publications

Serological cross-reactions between four polyomaviruses of birds using virus-like particles expressed in yeast

Serological cross-reactions between four polyomaviruses of birds using virus-like particles expressed in yeast

Exposure to raccoon polyomavirus (RacPyV) in free-ranging North American raccoons (Procyon lotor)

<b>Caracterização molecular de bornavírus, poliomavírus e circovírus em aves de cativeiro, vida livre e criação comercial</b>

Contact Info

Product

Resources

About