A look beyond the priority: A systematic review of the genotoxic, mutagenic, and carcinogenic endpoints of non-priority PAHs

Silva, Francisco Carlos da; Felipe, Maria Beatriz Mesquita Cansanção; Castro, Denis Elvis Farias de; Araújo, Sinara Carla da Silva; Sisenando, Herbert Costa Nóbrega; Medeiros, Silvia Regina Batistuzzo de

doi:10.1016/j.envpol.2021.116838

Cited by 69 publications

(21 citation statements)

References 252 publications

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“…Polycyclic aromatic hydrocarbons are hazardous pollutants, as exposure to these harmful substances increases the chance of developing cancer, 25 due to the harmful effects that these toxins and their reactive metabolites, such as dihydrodiols and epoxides, can have when they join to DNA and cellular proteins 26 like mutations, problems in development, and cancers that occur from the cell damage. 27 The results of this study showed the presence of high concentrations of polycyclic aromatic hydrocarbons in the blood serum of the traffic police who are at the busy street intersections of the city of Baghdad, relative to the levels in the blood serum of the office police group.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of DNA Damage in Traffic Cops Exposed to Polycyclic Aromatic Hydrocarbon Pollution in Baghdad City Streets and its Association to Certain Biomarkers

Salem¹,

Al-Wasiti

Hasan

2022

J. Contemp. Med. Sci.

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Objectives: To find out the extent to which the genetic material of Baghdad traffic policemen is affected by the oxidative damage caused by pollutants by monitoring the levels of 8-OHdG compared to the levels of antioxidant enzymes and malondialdehyde. Methods: This study includes 140 participants; they have been divided into two groups (traffic police and office police). Polycyclic aromatic hydrocarbons were analyzed for each participant by GC/FID while 8-OHdG and antioxidant enzymes were measured by the ELISA technique. Results: The levels of polycyclic aromatic hydrocarbons, 8-Oxo-dG, and malondialdehyde were elevated in the blood of the traffic police compared to the office police, while higher levels of antioxidant enzymes (Catalase and glutathione peroxidase) were observed in the blood of the office police. Conclusion: Exposure to polycyclic aromatic hydrocarbones can cause oxidative stress through their metabolic derivatives and the resulting active molecules, which lead to the formation of 8-Oxo-dG and the reduction of enzymatic antioxidants, which may lead to the emergence of cancers.

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Section: Discussionmentioning

confidence: 99%

Evaluation of DNA Damage in Traffic Cops Exposed to Polycyclic Aromatic Hydrocarbon Pollution in Baghdad City Streets and its Association to Certain Biomarkers

Salem¹,

Al-Wasiti

Hasan

2022

J. Contemp. Med. Sci.

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“…PAHs have been applied to electronic devices such as organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and organic field-effect transistors (OFETs) . PAHs are toxic compounds that show carcinogenic and mutagenic effects . On the other hand, they have potential as medicinal compounds displaying antitumor activity .…”

Section: Introductionmentioning

confidence: 99%

Oxidative β-Cleavage of Fused Cyclobutanols Leading to Hydrofuran-Fused Polycyclic Aromatic Compounds

et al. 2021

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Treatment of aryl-fused bicyclo[4.2.0]octanols with an oxidant such as phenyliodine diacetate (PIDA) or hypochlorous acid gave dihydrofuran-containing polycyclic aromatic compounds by selective β-cleavage of the cyclobutanol moiety. Mechanistic studies suggest that the oxygen atom of the hydrofuran ring is incorporated from the hydroxy group of the substrate via intramolecular addition. The oxidative transformation should serve as a new method to prepare functionalized polycyclic aromatic compounds.

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“…Amongst all other water pollutants, PAHs are hazardous organic compounds that are naturally non-biodegradable due to their chemical properties. PAHs can quickly accumulate in the human body and cause carcinogenic diseases such as skin cancer, kidney failure, ulcers, brain damage, hepatitis, and liver damage [3]. These refractory organic pollutants are also present in oil and gas extraction industries' wastewater in considerable amounts [4].…”

Section: Introductionmentioning

confidence: 99%

“…The range of PAH concentration in PW reported by various research is from 124 to 1000 µg L −1 [6][7][8][9], and these pollutants are precarious even in low concentrations (µg L −1 -mg L −1 ) [7]. In addition, the United States Environmental Protection Agency has declared 16 PAHs as priority chemicals because of their mutagenic and carcinogenic effects [3]. Globally, approximately half a million tons of PW are produced from oil and gas exploration industries [10].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Micro-Pollutants’ Removal from Wastewater Using Agricultural Waste-Derived Sustainable Adsorbent

Alhothali

Haneef

Mustafa

et al. 2021

IJERPH

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Water pollution due to the discharge of untreated industrial effluents is a serious environmental and public health issue. The presence of organic pollutants such as polycyclic aromatic hydrocarbons (PAHs) causes worldwide concern because of their mutagenic and carcinogenic effects on aquatic life, human beings, and the environment. PAHs are pervasive atmospheric compounds that cause nervous system damage, mental retardation, cancer, and renal kidney diseases. This research presents the first usage of palm kernel shell biochar (PKSB) (obtained from agricultural waste) for PAH removal from industrial wastewater (oil and gas wastewater/produced water). A batch scale study was conducted for the remediation of PAHs and chemical oxygen demand (COD) from produced water. The influence of operating parameters such as biochar dosage, pH, and contact time was optimized and validated using a response surface methodology (RSM). Under optimized conditions, i.e., biochar dosage 2.99 g L−1, pH 4.0, and contact time 208.89 min, 93.16% of PAHs and 97.84% of COD were predicted. However, under optimized conditions of independent variables, 95.34% of PAH and 98.21% of COD removal was obtained in the laboratory. The experimental data were fitted to the empirical second-order model of a suitable degree for the maximum removal of PAHs and COD by the biochar. ANOVA analysis showed a high coefficient of determination value (R2 = 0.97) and a reasonable second-order regression prediction. Additionally, the study also showed a comparative analysis of PKSB with previously used agricultural waste biochar for PAH and COD removal. The PKSB showed significantly higher removal efficiency than other types of biochar. The study also provides analysis on the reusability of PKSB for up to four cycles using two different methods. The methods reflected a significantly good performance for PAH and COD removal for up to two cycles. Hence, the study demonstrated a successful application of PKSB as a potential sustainable adsorbent for the removal of micro-pollutants from produced water.

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A look beyond the priority: A systematic review of the genotoxic, mutagenic, and carcinogenic endpoints of non-priority PAHs

Cited by 69 publications

References 252 publications

Evaluation of DNA Damage in Traffic Cops Exposed to Polycyclic Aromatic Hydrocarbon Pollution in Baghdad City Streets and its Association to Certain Biomarkers

Evaluation of DNA Damage in Traffic Cops Exposed to Polycyclic Aromatic Hydrocarbon Pollution in Baghdad City Streets and its Association to Certain Biomarkers

Oxidative β-Cleavage of Fused Cyclobutanols Leading to Hydrofuran-Fused Polycyclic Aromatic Compounds

Optimization of Micro-Pollutants’ Removal from Wastewater Using Agricultural Waste-Derived Sustainable Adsorbent

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