A low-cost integrated biosensing platform based on SiN nanophotonics for biomarker detection in urine

Martens, Daan; Ramirez-Priego, Patricia; Murib, Mohammed Sharif; Elamin, Ayssar A.; González-Guerrero, Ana Belén; Stehr, Matthias; Jonas, Friedrich; Anton, Birgit; Hlawatsch, Nadine; Soetaert, Pieterjan; Vos, Rita; Stassen, Andim; Severi, S.; Roy, W. Van; Bockstaele, Ronny; Becker, Holger; Singh, Mahavir; Lechuga, Laura M.; Bienstman, Peter

doi:10.1039/c8ay00666k

Cited by 48 publications

(39 citation statements)

References 18 publications

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Section: Emerging Sensor Designs and Biosensing Strategiesmentioning

confidence: 99%

“…Compared to silicon, SiN featuring a transparency window in shorter wavelengths (<1.1 µm) is highly sought for a miniaturized low‐cost system utilizing widely available light sources such as LEDs, laser diodes and CMOS cameras. Recently, Martens et al developed a SiN MZI‐based biosensing system working in the wavelength around 850 nm using a superluminescent diode, [ 94 ] which is compatible with the response range of CMOS cameras. As illustrated in Figure 8b, the signal is filtered by AWG into 30 channels so that the spectrum can be reconstructed from the discretized data by fitting.…”

Section: Emerging Sensor Designs and Biosensing Strategiesmentioning

confidence: 99%

“…In 2018, Martens et al developed a low‐cost SiN MZI‐based biosensing chip integrated with a polymer microfluidic cartridge providing an automatic fluidic handling process, as shown in Figure 9f,g. [ 94 ] Figure 9h displays the sensor layout with six multiplexed BB‐MZI biosensors with corresponding AWGs working in the wavelength of ≈900 nm. Only off‐chip LEDs and a camera are required without the need to process critical optical alignments, which renders the system affordable for POC applications.…”

Section: Laboratory Prototypes Toward Poc Applicationsmentioning

confidence: 99%

“…Only off‐chip LEDs and a camera are required without the need to process critical optical alignments, which renders the system affordable for POC applications. [ 94 ] Immunoassays were carried out with label‐free detection of CRP with a calibrated LOD of 19.5 ng mL −1 . Recently, the system has also been successfully applied for tuberculosis diagnosis using clinical urine samples from patients.…”

Section: Laboratory Prototypes Toward Poc Applicationsmentioning

confidence: 99%

See 3 more Smart Citations

Silicon‐Based Integrated Label‐Free Optofluidic Biosensors: Latest Advances and Roadmap

Wang

Sánchez

Yin

et al. 2020

Adv Materials Technologies

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By virtue of the well‐developed micro‐ and nanofabrication technologies and rapidly progressing surface functionalization strategies, silicon‐based devices have been widely recognized as a highly promising platform for the next‐generation lab‐on‐a‐chip bioanalytical systems with a great potential for point‐of‐care medical diagnostics. Herein, an overview of the latest advances in silicon‐based integrated optofluidic label‐free biosensing technologies relying on the efficient interactions between the evanescent light field at the functionalized surface and specifically bound analytes is presented. State‐of‐the‐art technologies demonstrating label‐free evanescent wave‐based biomarker detection mainly encompass three device configurations, including on‐chip waveguide‐based interferometers, microring resonators, and photonic‐crystal‐based cavities. Moreover, up‐to‐date strategies for elevating the sensitivities and also simplifying the sensing processes are discussed. Emerging laboratory prototypes with advanced integration and packaging schemes incorporating automatic microfluidic components or on‐chip optoelectronic devices lead to one significant step forward in real applications of decentralized diagnostics. Besides, particular attention is paid to currently commercialized label‐free optical bioanalytical models on the market. Finally, the prospects are elaborated with several research routes toward chip‐scale, low‐cost, highly sensitive, multi‐functional, and user‐friendly bioanalytical systems benefiting to global healthcare.

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Section: Emerging Sensor Designs and Biosensing Strategiesmentioning

confidence: 99%

Section: Emerging Sensor Designs and Biosensing Strategiesmentioning

confidence: 99%

Section: Laboratory Prototypes Toward Poc Applicationsmentioning

confidence: 99%

Section: Laboratory Prototypes Toward Poc Applicationsmentioning

confidence: 99%

See 2 more Smart Citations

Silicon‐Based Integrated Label‐Free Optofluidic Biosensors: Latest Advances and Roadmap

Wang

Sánchez

Yin

et al. 2020

Adv Materials Technologies

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show abstract

“…The detection sensitivities achieved were rather moderate but the potential to overcome the phase ambiguity issue was demonstrated. In an effort to create a low-cost integrated nanophotonic lab-on-a-chip platform, a silicon chip that included multiple Mach-Zehnder interferometers along with an on-chip optical spectral analyser consisting of an arrayed-waveguide grating as well as a grating for coupling of broad-band light was fabricated [114]. The sensor exhibited a refractive index LOD of 6x10 -6 RIU that is comparable to those of LODs achieved with standard MZIs.…”

Section: Monolithically Integrated Broad-band Optoelectronic Transducersmentioning

confidence: 99%

Label-Free Biosensors Based Onto Monolithically Integrated Onto Silicon Optical Transducers

Angelopoulou¹,

Kakabakos²,

Petrou³

2018

Preprint

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The article reviews the current status of label-free integrated optical sensors focusing on the evolution over the years of their analytical performance. At first a short introduction to the evanescent wave optics is provided followed by detailed description of the main categories of label-free optical sensors including sensors based on surface plasmon resonance (SPR), grating coupler, photonic crystals, ring resonators and interferometric transducers. After a short reference to SPR techniques, including localized SPR, integrated optical sensors i.e., grating-couplers, interferometers, photonic crystals, microring resonators are reviewed. For each type of sensor, the detection principle is first provided followed by description of the different transducer configurations so far developed and their performance as biosensors. Finally, a short discussion about the current limitations and future perspectives of integrated label-free biosensors optical sensors is provided

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Refractometric Imaging and Biodetection Empowered by Nanophotonics

Geng

Shum

et al. 2023

Laser & Photonics Reviews

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Advancing clinical and nonclinical diagnostic technologies is particularly crucial for improved preparedness for the next pandemic and other global healthcare challenges. To this end, marrying advanced microscopic imaging with chip‐scale bioanalytical systems provides fresh modalities by analyzing signals of transmitted, reflected, or scattered light waves. This review brings clarity to the latest progress of refractometric imaging and biodetections on a chip, in which interferences and resonances as cornerstones of optics and plasmonics are breaking new ground. A vast range of nanophotonic and plasmonic transducers are discussed, ranging from planar films, nanoarrays, and waveguiding resonators to holistic designs. The augmented bioanalyses cover immunoassays, single‐molecule analysis, and motion tracking of bacterial pathogens and cells. Compared to single‐point spectroscopic measurements, imaging‐empowered approaches are rapidly evolving with greatly promoted signal‐noise ratio, spatial‐temporal resolutions, multiplexability, and throughput, which can be accomplished in a compact cradle system with minimized bulky components in a spectrometer‐free manner. Besides, advances in machine learning technologies applied for data analytics and transducer designs are highlighted. All in all, there are unlimited opportunities for new optical structures, principles, and ways of data retrieval to tap in, which will raise technological impacts on unveiling fundamental issues in life science and advancing global healthcare technologies.

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A low-cost integrated biosensing platform based on SiN nanophotonics for biomarker detection in urine

Abstract: We present a low-cost integrated nanophotonic lab-on-a-chip platform suitable for point-of-care (POC) biomarker analysis.

Cited by 48 publications

References 18 publications

Silicon‐Based Integrated Label‐Free Optofluidic Biosensors: Latest Advances and Roadmap

Silicon‐Based Integrated Label‐Free Optofluidic Biosensors: Latest Advances and Roadmap

Label-Free Biosensors Based Onto Monolithically Integrated Onto Silicon Optical Transducers

Refractometric Imaging and Biodetection Empowered by Nanophotonics

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