2017
DOI: 10.1039/c7an01253e
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A luminescent and colorimetric probe based on the functionalization of gold nanoparticles by ruthenium(ii) complexes for heparin detection

Abstract: A sensitive assay was demonstrated for the colorimetric and luminescent detection of heparin. Positively charged [Ru(phen)np] (np: naphtho[2,3-f][1,10]phenanthroline) can interact with negatively charged AuNPs through electrostatic interaction, leading to the luminescence quenching of [Ru(phen)np]via energy transfer as well as the aggregation of AuNPs together with a color change in solution from red to blue. Upon the addition of negatively charged heparin to gold nanoparticles functionalized by ruthenium(ii) … Show more

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Cited by 15 publications
(8 citation statements)
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“…The detection limit of heparin at a signal-to-noise ratio of 3 is 0.3 μg·mL –1 . The sensitivity of the colorimetric method is comparable to previous reports. The Au-NCs are widely used as fluorescent probes because of their bright emission and low toxicity. The fluorescence responses of Au-NCs toward heparin were also investigated.…”
Section: Resultssupporting
confidence: 75%
“…The detection limit of heparin at a signal-to-noise ratio of 3 is 0.3 μg·mL –1 . The sensitivity of the colorimetric method is comparable to previous reports. The Au-NCs are widely used as fluorescent probes because of their bright emission and low toxicity. The fluorescence responses of Au-NCs toward heparin were also investigated.…”
Section: Resultssupporting
confidence: 75%
“…Similarly, the dosage of the anticoagulant heparin should be tightly regulated during surgery and postoperative care as high doses and prolonged use can lead to serious side effects. A sensitive assay was developed for colorimetric and luminescent detection of heparin using gold nanoparticles functionalized with ruthenium­(II) complexes . The assay was tested with fetal bovine serum; however, it has yet to be tested in human biological fluids.…”
Section: Drug Monitoringmentioning
confidence: 99%
“…A sensitive assay was developed for colorimetric and luminescent detection of heparin using gold nanoparticles functionalized with ruthenium(II) complexes. 15 The assay was tested with fetal bovine serum; however, it has yet to be tested in human biological fluids.…”
Section: ■ Drug Monitoringmentioning
confidence: 99%
“…Notably, luminescent metal complexes (with Ru 2+ , Fe 3+ , Zn 2+ , etc.) with polypyridine ligands, such as 2,2′-bipyridyl (bpy) or 1,10-phenanthroline (phen), have received a significant amount of attention recently as responsive photofunctional materials. In particular, the unique photophysical properties of Ru­(II) polypyridyl complexes include broad absorption maxima, reversible redox properties, large Stoke shifts, etc. In addition, high water solubility and biocompatibility make these probes a useful “photoswitching material” for biomolecules, such as DNA, protein, etc. Our findings present a unique instance in which a luminescent probe has been utilized for the detection and quantitative analysis of SLNPV via a color-changing response. Interestingly, the freshly prepared SLNPV has been differentiated from its storage-old analogues and other biopesticides.…”
Section: Introductionmentioning
confidence: 99%