A malaria vaccine adjuvant based on recombinant antigen binding to liposomes

Huang, Wei‐Chiao; Deng, Bingbing; Lin, Cuiyan; Carter, Kevin A.; Geng, Jumin; Razi, Aida; He, Xuedan; Chitgupi, Upendra; Federizon, Jasmin; Sun, Boyang; Long, Carole A.; Ortega, Joaquı́n; Dutta, Sandeep; King, C. Richter; Miura, Kazutoyo; Lee, Shwu-Maan; Lovell, Jonathan F.

doi:10.1038/s41565-018-0271-3

Cited by 116 publications

(133 citation statements)

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“…The same group used liposomes modified with a fragment of tetanus toxoid as an antigen and PEGylated peptide adjuvants to target the Fc receptor of dendritic cells as a cancer vaccine . Recently, Lovell and co‐workers appended a recombinant polyhistidine‐tagged version of a malaria transmission‐blocking antigen (Pfs25) to the surfaces of liposomes, which induced a potent humoral immune response mediated by dendritic cell cross‐presentation …”

Section: Nanoscale Materials For Immunotherapymentioning

confidence: 99%

Materials for Immunotherapy

et al. 2019

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Breakthroughs in materials engineering have accelerated the progress of immunotherapy in preclinical studies. The interplay of chemistry and materials has resulted in improved loading, targeting, and release of immunomodulatory agents. An overview of the materials that are used to enable or improve the success of immunotherapies in preclinical studies is presented, from immunosuppressive to proinflammatory strategies, with particular emphasis on technologies poised for clinical translation. The materials are organized based on their characteristic length scale, whereby the enabling feature of each technology is organized by the structure of that material. For example, the mechanisms by which i) nanoscale materials can improve targeting and infiltration of immunomodulatory payloads into tissues and cells, ii) microscale materials can facilitate cell‐mediated transport and serve as artificial antigen‐presenting cells, and iii) macroscale materials can form the basis of artificial microenvironments to promote cell infiltration and reprogramming are discussed. As a step toward establishing a set of design rules for future immunotherapies, materials that intrinsically activate or suppress the immune system are reviewed. Finally, a brief outlook on the trajectory of these systems and how they may be improved to address unsolved challenges in cancer, infectious diseases, and autoimmunity is presented.

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Section: Nanoscale Materials For Immunotherapymentioning

confidence: 99%

Materials for Immunotherapy

et al. 2019

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Section: B Cells Act As Apcs To Activate Cellular Response Against VImentioning

confidence: 99%

“…[51] These NPs readily incorporate multiple antigens, which is particularly relevant for addressing the multiple stages of malaria. [51] These NPs readily incorporate multiple antigens, which is particularly relevant for addressing the multiple stages of malaria.…”

Section: Malaria Vaccine Enhanced By Co-delivery Of Antigens and Innamentioning

confidence: 99%

“…[51] These NPs readily incorporate multiple antigens, which is particularly relevant for addressing the multiple stages of malaria. [51] The liposome core of the antigen-presenting NPs integrated a synthetic monophosphoryl lipid A (PHAD), which is a TLR4 agonist. SNAP NPs with malaria antigens induced long-lasting functional antibodies against malaria in mice and rabbits ( Figure 2G).…”

Section: Malaria Vaccine Enhanced By Co-delivery Of Antigens and Innamentioning

confidence: 99%

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Engineering Biomaterials to Direct Innate Immunity

Oakes

Froimchuk

Jewell

2019

Advanced Therapeutics

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Small alterations during early stages of innate immune response can drive large changes in how adaptive immune cells develop and function during protective immunity or disease. Controlling these events creates exciting potential in the development of immune engineered vaccines and therapeutics. This progress report discusses recent biomaterial technologies exploiting innate immunity to dissect immune function and to design new vaccines and immunotherapies for infectious diseases, cancer, and autoimmunity. Across these examples, an important idea is the possibility to co-opt innate immune mechanisms to enhance immunity during infection and cancer. During inflammatory or autoimmune disease, some of these same innate immune mechanisms can be manipulated in different ways to control excess inflammation by promotion of immunological tolerance.

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“…The previous examples discussed the importance of antigen density in the context of autoimmune disease, but this feature is also important in mounting immune responses against infectious diseases. As one illustration, recent studies have exploited liposomes to control how malaria antigens are presented . These liposomes are designed to load antigens into the membrane stably by coordinating interactions with metal ions located in the particles.…”

Section: Biomaterials Provide Control Over the Molecular Properties Omentioning

confidence: 99%

Biomaterials as Tools to Decode Immunity

Eppler¹,

Jewell

2019

Advanced Materials

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The immune system has remarkable capabilities to combat disease with exquisite selectivity. This feature has enabled vaccines that provide protection for decades and, more recently, advances in immunotherapies that can cure some cancers. Greater control over how immune signals are presented, delivered, and processed will help drive even more powerful options that are also safe. Such advances will be underpinned by new tools that probe how immune signals are integrated by immune cells and tissues. Biomaterials are valuable resources to support this goal, offering robust, tunable properties. The growing role of biomaterials as tools to dissect immune function in fundamental and translational contexts is highlighted. These technologies can serve as tools to understand the immune system across molecular, cellular, and tissue length scales. A common theme is exploiting biomaterial features to rationally direct how specific immune cells or organs encounter a signal. This precision strategy, enabled by distinct material properties, allows isolation of immunological parameters or processes in a way that is challenging with conventional approaches. The utility of these capabilities is demonstrated through examples in vaccines for infectious disease and cancer immunotherapy, as well as settings of immune regulation that include autoimmunity and transplantation.

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A malaria vaccine adjuvant based on recombinant antigen binding to liposomes

Cited by 116 publications

References 50 publications

Materials for Immunotherapy

Materials for Immunotherapy

Engineering Biomaterials to Direct Innate Immunity

Biomaterials as Tools to Decode Immunity

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