1981
DOI: 10.1007/bf00431075
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A malignant tumor arising from interdigitating cells; Light microscopical, ultrastructural, immuno- and enzyme-histochemical characteristics

Abstract: A tumor in a 37 years old male is described in which the tumor cells appeared to be derived from interdigitating cells normally found in the T-cell area of lymph nodes. The patient presented with superior vena caval obstruction due to a mediastinal mass, followed by lymph node enlargement and skin lesions leading to death within 4 months. The tumor cells lacked immune markers for lymphocytic cells. They showed Ia-like antigens and high adenosine triphosphatase activity, while acid phosphatase and alpha-naphthy… Show more

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Cited by 78 publications
(27 citation statements)
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“…18 Patients were usually diagnosed with painless lymph node involvement, while systemic symptoms including fever, weight loss, fatigue or night sweats are rarely reported. 19 Clinical behavior and prognosis are heterogeneous. A recent overview of published cases of dendritic cell sarcoma, including 55 cases of interdigitating cell sarcoma, has reported that the recurrence rate after surgical resection is 50% for tumors of at least 5 cm and 11.1% when the size is inferior to 5 cm.…”
Section: Discussionmentioning
confidence: 99%
“…18 Patients were usually diagnosed with painless lymph node involvement, while systemic symptoms including fever, weight loss, fatigue or night sweats are rarely reported. 19 Clinical behavior and prognosis are heterogeneous. A recent overview of published cases of dendritic cell sarcoma, including 55 cases of interdigitating cell sarcoma, has reported that the recurrence rate after surgical resection is 50% for tumors of at least 5 cm and 11.1% when the size is inferior to 5 cm.…”
Section: Discussionmentioning
confidence: 99%
“…Local and distant recurrence within 1-2 years after CHOP chemotherapy has been reported [25,30]. Adjuvant combined chemotherapy and radiotherapy have been used in patients with local disease yielding limited benefit [27,76,77,78]. Good results were seen in patients who received neo-adjuvant radiotherapy and chemotherapy [27].…”
Section: Treatmentmentioning
confidence: 99%
“…There are 21 well-documented cases of IDDCS reported in the literature. The patients usually presented with lymphadenopathy [2,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30], and a few had constitutional symptoms such as fever (4/21, 19%). The median age at presentation was 52 years (range, eight to 74 years), and there was a slight male predilection (15/21).…”
Section: Interdigitating Dendritic Cell Sarcomamentioning
confidence: 99%
“…FDCS and IDDCS are rare and pose a diagnostic challenge to the surgical pathologist. It may be difficult, on morphologic review alone, to differentiate these diseases from each other and from other neoplastic processes, including Hodgkin's [27] CHOP PR Miettinen et al [25] CHOP CR Rabkin et al [23] MACOP-B PR Salisbury et al [22] M-BACOD Stable Miettinen et al [25] M-BACOD Progression Ara-C, P1, E Progression Turner et al [19] ABO Progression Chan and Zaatari [29] BACO Progression Horschowski et al [26] P, Lasp, Vn, DN Progression Daum et al [21] POACEMcPr PR Rousselet et al [24] M-BACOD + radiation PR MINE PR Feltkamp et al [17] CHOP + radiation Progression CHOP Progression Hammar et al [28] COP + radiation CR Rabkin et al [23] COP + radiation Progression disease, non-Hodgkin's lymphoma, soft tissue sarcomas, or nonneoplastic entities such as extranodal inflammatory pseudotumor. The use of immunohistochemical methods, electron microscopy, and molecular genetic studies usually helps to exclude Hodgkin's disease and non-Hodgkin's lymphoma.…”
Section: Differential Diagnosis Of Fdcs and Iddcsmentioning
confidence: 99%
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