A Maple Syrup Extract Prevents β-Amyloid Aggregation

Effects of a Standardized Phenolic-Enriched Maple Syrup Extract on β-Amyloid Aggregation, Neuroinflammation in Microglial and Neuronal Cells, and β-Amyloid Induced Neurotoxicity in Caenorhabditis elegans

“…These data are in agreement with the previous report for a phenolic-enriched maple syrup extract [20]. However, to date, no previous studies have been conducted to evaluate the neuroprotective effects of maple syrup in brain cells or in an in vivo AD model; therefore, we proceeded with the following experiments (described below).…”

“…However, further in vivo studies to confirm the neuroprotective effects of MSX, and to predict a human equivalent consumption dose, are necessary given that the current data does not account for important physiological considerations such as bioavailability and metabolism. Nevertheless, these findings add to recently published data supporting the potential neuroprotective effects of maple syrup [20, 21], warranting further studies on this natural plant-derived sweetener.…”

“…However, despite the wide consumption of maple syrup worldwide, and knowledge that it contains a diverse array of phenolic constituents (over fifty phenolics belonging to lignan, stilbene, flavonoid, coumarin, and phenolic acid sub-classes have been isolated and identified from maple syrup) [17–19, 22], studies evaluating their health promoting effects are very limited. Moreover, based on our knowledge to date, few studies have been conducted to evaluate the neuroprotective effects of this natural sweetener [20, 21]. In one of those studies, a phenolic-enriched maple syrup extract was shown to decrease oligomerization and aggregation of both Aβ 1–42 and tau peptides, which are proteins involved in AD pathogenesis [20].…”

“…Moreover, based on our knowledge to date, few studies have been conducted to evaluate the neuroprotective effects of this natural sweetener [20, 21]. In one of those studies, a phenolic-enriched maple syrup extract was shown to decrease oligomerization and aggregation of both Aβ 1–42 and tau peptides, which are proteins involved in AD pathogenesis [20]. In light of the aforementioned factors, and given the paucity of data on the neuroprotective effects of natural plant-derived sweeteners, including maple syrup, we designed the current study.…”

Anti-glycation and anti-oxidative effects of a phenolic-enriched maple syrup extract and its protective effects on normal human colon cells

“…15, 16 Maple syrup contains a wide variety of phenolic constituents 17–19 and in our group’s ongoing research on this natural product, 16, 18–21 we have developed a phenolic-enriched maple syrup extract (MSX) for nutraceutical applications which is well-tolerated and non-toxic to rats (at doses of up to 1000 mg/kg/day). 20 Phenolic-enriched extracts of maple syrup have been reported to show antioxidant 18 , anti-diabetic, 20–22 anticancer, 23 anti-inflammatory 24, 25 , and neuroprotective 26, 27 properties in vitro. More recently, our group has also reported on the neuroprotective effects of MSX on murine microglia BV-2 cells, human neuronal SH-SY5Y cells, and against neurotoxicity in Caenorhabditis elegans in vivo.…”