A Massive Thymic Carcinoma Presenting as Superior Vena Cava and Inferior Vena Cava Syndromes

Maekura, Toshiya; Nakamura, Takahito; Maruyama, Hiroshi; Tokitsu, Kousuke; Orino, Tatsuhiko

doi:10.2482/haigan.51.202

Cited by 1 publication

(3 citation statements)

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“…The first case was a 76-year-old Japanese man with thymic carcinoma that invaded the region surrounding the IVC through the diaphragm, compressing the IVC. 26 Furthermore, myocardial necrosis with lymphocytic infiltration beneath the epicardium was observed in the present case. Pericarditis associated with myocardial infarction may be reminiscent of post-acute myocardial infarction syndrome, also known as Dressler syndrome.…”

Section: Discussionsupporting

confidence: 60%

“…To the best of our knowledge, this is the second case of IVC syndrome associated with thymic neoplasms extending into the right atrium. The first case was a 76‐year‐old Japanese man with thymic carcinoma that invaded the region surrounding the IVC through the diaphragm, compressing the IVC . Furthermore, myocardial necrosis with lymphocytic infiltration beneath the epicardium was observed in the present case.…”

Section: Discussionmentioning

confidence: 51%

“…Although tumor invasion of mediastinal organs such as the pericardium, pleura, and lungs have been reported, a case with tumor emboli in the pulmonary arteries has never been reported to the best of our knowledge, partly because the present case is a rare autopsy report. Indeed, only two autopsy reports in this category have been published in Japanese, but the present case is the first English autopsy report.…”

Section: Discussionmentioning

confidence: 99%

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Intracaval and intracardiac extension of invasive thymoma complicated by superior and inferior vena cava syndrome

Kurata

Saji

Ikeda

et al. 2012

Pathology International

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We present a case of an aged male with invasive thymoma that extended into the right atrium and led to superior and inferior vena cava syndrome. The patient initially presented with edema of the face and bilateral lower extremities. Echocardiography revealed a mass within the right atrium. Imaging studies demonstrated an anterior mediastinal tumor that continuously occupied the bilateral brachiocephalic veins, superior vena cava, and right atrium. Pathological diagnosis of the tumor biopsy was highly suspicious of thymoma. Due to the high risk of wide spread of the tumor, treatments including resection of the tumor were impossible. Several days later he died, and an autopsy was performed. The tumor was type B2 thymoma invading bilateral brachiocephalic veins, superior vena cava and right atrium. Multiple tumor emboli within the pulmonary arteries were identified. Direct cause of death was deemed to be tumor strangulation at the tricuspid orifice. In addition to the superior vena cava syndrome, inferior vena cava syndrome including ectasia of the intrahepatic vessels was confirmed along with pericarditis. To our knowledge, this is the first English report of an autopsy case of intracardiac thymoma extension, and a detailed literature review of similar cases is also presented.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

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