2024
DOI: 10.1371/journal.pcbi.1012082
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A mathematical model for the role of dopamine-D2 self-regulation in the production of ultradian rhythms

An Qi Zhang,
Martin R. Ralph,
Adam R. Stinchcombe

Abstract: Many self-motivated and goal-directed behaviours display highly flexible, approximately 4 hour ultradian (shorter than a day) oscillations. Despite lacking direct correspondence to physical cycles in the environment, these ultradian rhythms may be involved in optimizing functional interactions with the environment and reflect intrinsic neural dynamics. Current evidence supports a role of mesostriatal dopamine (DA) in the expression and propagation of ultradian rhythmicity, however, the biochemical processes un… Show more

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