A Mathematician's Odyssey

Bodmer, Walter F.

doi:10.1146/annurev-genom-090314-045856

Annu. Rev. Genom. Hum. Genet.

2015

DOI: 10.1146/annurev-genom-090314-045856

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A Mathematician's Odyssey

Walter F. Bodmer¹

Abstract: In this overview of my research, I have aimed to give the background as to how I came to be involved in my various areas of interest, with an emphasis on the early phases of my career, which largely determined my future directions.

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Cited by 3 publications

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“…An excellent history of the HLA system up to 1990 was assembled by Terasaki based on contributions from all the major HLA pioneers ([ 7 ], and see also [ 8 ] for further references).…”

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confidence: 99%

A historical perspective on HLA

Bodmer

2023

Immunotherapy Advances

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The discovery of the history of the HLA system is reviewed from the earliest attempts at cancer transfers between mice, through the discovery of the mouse H-2 system on mouse red blood cells, the discovery of HLA class II and II antigens by use of sera from multiparous women, to the resolution of the HLA and H-2 functions explained by the attachment of intra cellular peptides to the HLA antigen grooves on the cell surface. The study of the associations between HLA types and diseases forms the basis for the subsequent extensive study of the genetics of human complex disease and phenotypes by GWAS (Genome Wide Association Studies).

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“…An excellent history of the HLA system up to 1990 was assembled by Terasaki based on contributions from all the major HLA pioneers ([ 7 ], and see also [ 8 ] for further references).…”

mentioning

confidence: 99%

A historical perspective on HLA

Bodmer

2023

Immunotherapy Advances

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Richard Lewontin and the “complications of linkage”

Dietrich

Harman

Lamm

2021

Studies in History and Philosophy of Science

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A Journey Through Genetics to Biology

Heyningen

2022

Annu. Rev. Genom. Hum. Genet.

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Although my engagement with human genetics emerged gradually, and sometimes serendipitously, it has held me spellbound for decades. Without my teachers, students, postdocs, colleagues, and collaborators, I would not be writing this review of my scientific adventures. Early gene and disease mapping was a satisfying puzzle-solving exercise, but building biological insight was my main goal. The project trajectory was hugely influenced by the evolutionarily conserved nature of the implicated genes and by the pace of progress in genetic technologies. The rich detail of clinical observations, particularly in eye disease, makes humans an excellent model, especially when complemented by the use of multiple other animal species for experimental validation. The contributions of collaborators and rivals also influenced our approach. We are very fortunate to work in this era of unprecedented progress in genetics and genomics. Expected final online publication date for the Annual Review of Genomics and Human Genetics, Volume 23 is October 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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A Mathematician's Odyssey

Abstract: In this overview of my research, I have aimed to give the background as to how I came to be involved in my various areas of interest, with an emphasis on the early phases of my career, which largely determined my future directions.

Cited by 3 publications

References 66 publications

A historical perspective on HLA

A historical perspective on HLA

Richard Lewontin and the “complications of linkage”

A Journey Through Genetics to Biology

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