A mean platelet volume in inflammatory bowel disease: A systematic review and meta-analysis

Bambo, Getachew Mesfin; Shiferaw, Elias; Melku, Mulugeta

doi:10.1371/journal.pone.0273417

Cited by 6 publications

(4 citation statements)

References 62 publications

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“…For MPV, our meta-analysis found that the changes in MPV among IBD patients were significantly lower compared to those in the control group, irrespective of whether they belonged to the UC or CD groups or the active and inactive groups. A previous meta-analysis has reported a decrease in MPV in IBD patients [ 112 ], which was consistent with our findings. The reduced MPV levels were frequently reported and exhibited a correlation with endoscopic findings and disease activity indexes, such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) [ 68 , 84 ].…”

Section: Discussionsupporting

confidence: 93%

Abnormal platelet parameters in inflammatory bowel disease: a systematic review and meta-analysis

Xu,

Song,

et al. 2024

BMC Gastroenterol

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Background Platelet dysfunction plays a critical role in the pathogenesis of inflammatory bowel disease (IBD). Despite clinical observations indicating abnormalities in platelet parameters among IBD patients, inconsistencies persist, and these parameters lack standardization for diagnosis or clinical assessment. Methods A comprehensive search was conducted in the PubMed, Embase, Web of Science, and Cochrane Library databases for relevant articles published up to December 16th, 2023. A random-effects model was employed to pool the weighted mean difference (WMD) and 95% confidence interval (95% CI) of platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) between IBD patients and healthy controls, and subgroup analyses were performed. Results The meta-analysis included 79 articles with 8,350 IBD patients and 13,181 healthy individuals. The results revealed significantly increased PLT and PCT levels (WMD: 69.910, 95% CI: 62.177, 77.643 109/L; WMD: 0.046%, 95% CI: 0.031%, 0.061%), and decreased MPV levels (WMD: -0.912, 95% CI: -1.086, -0.739 fL) in IBD patients compared to healthy individuals. No significant difference was found in PDW between the IBD and control groups (WMD: -0.207%, 95% CI: -0.655%, 0.241%). Subgroup analysis by disease type and disease activity showed no change in the differences for PLT, PCT, and MPV in the ulcerative colitis and Crohn’s disease groups, as well as the active and inactive groups. Notably, the active group exhibited significantly lower PDW levels than the control group (WMD: -1.138%, 95% CI: -1.535%, -0.741%). Conclusions Compared with healthy individuals, IBD patients display significantly higher PLT and PCT and significantly lower MPV. Monitoring the clinical manifestations of platelet abnormalities serves as a valuable means to obtain diagnostic and prognostic information. Conversely, proactive measures should be taken to prevent the consequences of platelet abnormalities in individuals with IBD. Systematic review registration PROSPERO CRD42023493848.

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Section: Discussionsupporting

confidence: 93%

Abnormal platelet parameters in inflammatory bowel disease: a systematic review and meta-analysis

Xu,

Song,

et al. 2024

BMC Gastroenterol

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“…They reported that PLT level was predictive in the detection of MH (Cut-off value <278.6x10 3 /µL; Sensitivity and 72.2% Specificity 46.2%), but MPV levels were not statistically significant. According to the meta-analysis of Bambo et al [ 17 ], MPV levels were lower in UC compared to the control. The decreased MPV levels were associated with the progression and severity of UC activity.…”

Section: Discussionmentioning

confidence: 99%

Platelet, Mean Platelet Volume and Platelet Distribution Width Levels Might Be a Promising Marker for the Prediction of Disease Severity, Mucosal Healing and Steroid Dependence in Patients With Ulcerative Colitis

Gerçeker¹,

Cerrah

2023

Cureus

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Background/aims: In this study, we aimed to determine the value of mean platelet (PLT) volume (MPV), PLT and PLT distribution width (PDW) levels as a marker in the prediction of mucosal healing (MH), steroid resistance (SR) and steroid dependence (SD) in newly diagnosed moderate and severely active patients with ulcerative colitis (UC), who did not receive medical treatment before. Patients/methods: Two hundred forty-nine patients with severely or moderately active UC and 50 healthy subjects were enrolled in the study after retrospective analysis. Disease severity and MH of UC were determined according to the Mayo Score. According to the results of remission induction therapy, the patients were divided into two groups: Group 1; MH positive and Group 2; MH negative. UC patients with clinical remission (CR) but without MH were divided into two subgroups SD and non-SD during their follow-up. These two groups and subgroups were compared for variables. Results: 42.6% of patients with UC had severe disease activation. 44.6% of patients with UC had pancolitis. After remission induction therapy, CR was observed in 84.3% of patients with UC. MH rate was 53.0%. SR rate was 15.7% and the SD rate was 16.1%. A strong positive correlation was observed between C reactive protein (CRP), PLT and Mayo score in the activation period (r=0.835 and p<0.001; r=0.883 and p<0.001; respectively). A strong negative correlation was observed between mean PLT volume (MPV), PDW levels and Mayo score (r=-0.905 and p<0.001; r=-0.805 and p<0.001; respectively). According to the receiver operating characteristic curve (ROC) analysis, PLT had a sensitivity of 42.4% and a specificity of 22.7% in the prediction of MH at a cut-off value of 266.5x10 3 /µL. MPV had a sensitivity of 83.5% and a specificity of 73.5% in the prediction of MH at a cut-off value of 8.05 fL. PDW had a sensitivity of 88.6% and a specificity of 84.5% in the prediction of MH at a cut-off value of 2.95 fL. PLT was determined with 92.5% sensitivity and 86.8% specificity in the prediction of SD at a cut-off value of 287.0x10 3 /µL. MPV had a sensitivity of 86.8% and a specificity of 67.5% in the prediction of SD at a cut-off value of 7.95 fL. PDW had a sensitivity of 73.7% and a specificity of 72.5% in the prediction of SD at a cut-off value of 12.55 fL. Conclusions: There was a positive correlation between PLT levels and Mayo score, and a negative correlation between Mayo score and MPV or PDW levels. We think that PLT, MPV and PDW levels may be promising markers in the evaluation of disease activation/remission and severity. We believe that PLT, MPV and PDW levels will be determinative especially in the exclusion of SD, for UC patients with CR but without MH.

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“…Inflammatory bowel disease (IBD) is one kind of chronic recurrent inflammation, including ulcerative colitis and Crohn's disease. 1 IBD patients develop mucosal ulcers, epithelial barrier destruction, rectal bleeding, and diarrhea, 2 , 3 , 4 even enhancing the risk of colon cancer. Current studies cannot elucidate the exact pathogenesis of IBD.…”

Section: Introductionmentioning

confidence: 99%

Ononin alleviates DSS‐induced colitis through inhibiting NLRP3 inflammasome via triggering mitophagy

Liang

et al. 2023

Immunity Inflam & Disease

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Background: Ononin, a flavonoid isolated from Astragalus membranaceus root, is the active ingredient of A. membranaceus and has potential anti‐inflammatory properties, but its effect on colitis is unclear. Aims: This study aimed to explore the anticolitis effect of Ononin by establishing a colitis model in mice induced by dextran sulfate sodium (DSS). Methods: Male C57BL/6 mice were provided DSS, then treated with Ononin (10, 20, 40 mg/kg) or 5‐ASA (40 mg/kg). The colitis symptoms were observed, the disease activity index (DAI) score were recorded daily, and colonic inflammation was evaluted by histopathological scoring. The expression of cytokines, inflammatory mediators, and mitophagy/NLRP3 inflammasome‐related proteins were measured. Results: Ononin significantly alleviated weight loss and colon shortening in mice with colitis ( p < .01). Moreover, Ononin decreased the production of inflammatory cytokines and mediators associated with colitis ( p < .05). In addition, Ononin inhibited macrophages infiltration and reduced caspase‐1 activation in colitis mice. Caspase‐1 activation is closely related to the NLRP3 inflammasome. Therefore, we investigated the effect of Ononin on NLRP3 inflammasome in vitro. The relevant results confirmed that Ononin inhibited NLRP3 inflammasome activation and inhibited mitochondrial damage ( p < .05). Further studies revealed that Ononin inhibited mitochondrial damage through triggering mitophagy ( p < .05). Conclusion: Ononin alleviates DSS‐induced colitis by activating mitophagy to inhibit NLRP3 inflammasome.

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A mean platelet volume in inflammatory bowel disease: A systematic review and meta-analysis

Cited by 6 publications

References 62 publications

Abnormal platelet parameters in inflammatory bowel disease: a systematic review and meta-analysis

Abnormal platelet parameters in inflammatory bowel disease: a systematic review and meta-analysis

Platelet, Mean Platelet Volume and Platelet Distribution Width Levels Might Be a Promising Marker for the Prediction of Disease Severity, Mucosal Healing and Steroid Dependence in Patients With Ulcerative Colitis

Ononin alleviates DSS‐induced colitis through inhibiting NLRP3 inflammasome via triggering mitophagy

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