A mechanical heart valve is the best choice

Jaffer, Iqbal H.; Whitlock, Richard

doi:10.1136/heartasia-2015-010660

Cited by 22 publications

(13 citation statements)

References 22 publications

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“…Our results on the assessment of adhesion properties showed that platelets adhere to all polymers, regardless of their type. The mechanism of platelet adhesion on the surface of the studied materials can be determined through the potential difference of polymers and platelets, and platelet adhesion can follow the adhesion of protein components of the blood, in this case, the hydrophobicity of polymers plays a crucial role [4]. The presence of methyl groups (-CH3) and the styrene benzene ring in the SIBS structure may provoke both protein adhesion and platelet adhesion [56].…”

Section: Discussionmentioning

confidence: 99%

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Polyisobutylene-Based Thermoplastic Elastomers for Manufacturing Polymeric Heart Valve Leaflets: In Vitro and In Vivo Results

et al. 2019

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Superior polymers represent a promising alternative to mechanical and biological materials commonly used for manufacturing artificial heart valves. The study is aimed at assessing poly(styrene-block-isobutylene-block-styrene) (SIBS) properties and comparing them with polytetrafluoroethylene (Gore-texTM, a reference sample). Surface topography of both materials was evaluated with scanning electron microscopy and atomic force microscopy. The mechanical properties were measured under uniaxial tension. The water contact angle was estimated to evaluate hydrophilicity/hydrophobicity of the study samples. Materials’ hemocompatibility was evaluated using cell lines (Ea.hy 926), donor blood, and in vivo. SIBS possess a regular surface relief. It is hydrophobic and has lower strength as compared to Gore-texTM (3.51 MPa vs. 13.2/23.8 MPa). SIBS and Gore-texTM have similar hemocompatibility (hemolysis, adhesion, and platelet aggregation). The subcutaneous rat implantation reports that SIBS has a lower tendency towards calcification (0.39 mg/g) compared with Gore-texTM (1.29 mg/g). SIBS is a highly hemocompatible material with a promising potential for manufacturing heart valve leaflets, but its mechanical properties require further improvements. The possible options include the reinforcement with nanofillers and introductions of new chains in its structure.

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Section: Discussionmentioning

confidence: 99%

“…To date, damaged native valves are replaced with mechanical and tissue heart valves. However, neither mechanical nor tissue prostheses are ideal [3,4]. Their implantation is associated with reduced quality of life.…”

Section: Introductionmentioning

confidence: 99%

Polyisobutylene-Based Thermoplastic Elastomers for Manufacturing Polymeric Heart Valve Leaflets: In Vitro and In Vivo Results

et al. 2019

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“…The valve replacement with mechanical prosthesis provides excellent long term freedom from symptoms as it improves the cardiac dimensions, recovers cardiac functional status, and prolongs overall survival. 1 However, it necessitates the use of warfarin for long term anticoagulation.…”

Section: Introductionmentioning

confidence: 99%

Continued use of Warfarin in lower dose has safe maternal and neonatal outcomes in pregnant women with Prosthetic Heart Valves

Nadeem¹,

Khilji²,

Ali³

et al. 2021

Pak J Med Sci

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Background and Objective: There has been concerns regarding the safety of Warfarin in pregnant females due to its teratogenic potential. At the same time warfarin provides best anticoagulation in patients with prosthetic valves. Various dosage regimes have been tried to strike a balance between safety of mother and the avoidance of congenital anomalies in the newborn. This study was conducted to observe the effect of Warfarin in pregnant mothers taking different doses of warfarin, and their neonatal outcome, in our outdoor patients. Methods: This is a cross sectional observational study conducted at the Faisalabad Institute of Cardiology. The pregnant mothers taking warfarin for prosthetic valve replacement who presented to our specialized clinic between November 2016 to April 2017 were included in the study. These included a total of 75 females between the age of 20-35 years. To compare the dose related effect of warfarin, two groups of the patients were formed. One group comprised of patients taking warfarin ≤5mg while the other group consisted of those who were taking >5mg of warfarin daily. These patients were followed till their delivery. The information was collected about the maternal and fetal outcomes. The maternal outcomes including mode of delivery/miscarriage, peripartum bleeding and any valve related thromboembolic complications. The fetal outcomes included birth weight, maturity, embryopathy and congenital anomaly in the baby. Results: Patient’s mean age was 29.25±3.75 years. The mitral valve replacement was present in 60% patients (n=45) while 25.3% patients (n=19) had aortic valve replacement and 14.7% patients (n=11) had double valve replacement. In this group 30 patients (40%) had taken <5 mg warfarin and 45 patients (60%) had received >5 mg warfarin medicine. Miscarriages, cesarean sections, low birth weight and prematurity were more common in patients receiving warfarin >5 mg with p-values 0.005, 0.046, 0.01 and 0.033 respectively. No case of fetal embryopathy was found in both groups. Conclusion: No case of embryopathy was found in each group which signifies that warfarin in lower doses is safe anticoagulant in patients with prosthetic valve replacements. doi: https://doi.org/10.12669/pjms.37.4.3924 How to cite this:Nadeem S, Khilji SA, Ali F, Jalal A. Continued use of Warfarin in lower dose has safe maternal and neonatal outcomes in pregnant women with Prosthetic Heart Valves. Pak J Med Sci. 2021;37(4):---------. doi: https://doi.org/10.12669/pjms.37.4.3924 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…Одним из основных недостатков механических клапанов сердца является необходимость перманентной антикоагулянтной терапии [5], направленной на снижение риска развития тромбоэмболических осложнений. Синтетическая природа материала, из которого изготавливаются такие протезы, оказывает влияние на свертывающую систему крови, вызывая тромбообразование [6].…”

Section: Introductionunclassified

“…5. «Решетчатые материалы»: а -1,6-гександиолдиакрилат (HDDA); б -трубчатый металл Ni-P; в -трубчатая алюминиевая керамика; г -твердая алюминиевая керамика; д-з -соответствующие снимки с увеличением «Lattice materials»: а -1,6-hexanediol diacrylate (HDDA); б -tubular metal of Ni-P; в -tubular aluminum ceramics; г -solid aluminum ceramics; д-з -corresponding images with magnifi cation…”

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Polymeric Heart Valve Prostheses: Condition and Perspectives

Резвова

Овчаренко

2018

RJTAO

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The idea of creating a polymer heart valve, which has high strength and biocompatibility, occurs in the 60’s. Since then, many polymer compounds have been investigated, but no solution has been found for this problem. In recent years, in connection with the development of technologies for the synthesis of high-molecular compounds, new polymers have appeared that can solve this problem, as evidenced by a number of publications describing experimental and clinical data. Nevertheless, the search for a polymer for the valve stem of the valvular valve body does not lose its relevance due to the deﬁ ciencies studied and the lack of evidence conﬁ rming the long-term safety of such products. This review presents the ﬁ rst results of a study of polymer heart valves prostheses based on a nanocomposite polymer from polyhedral oligomeric nanoparticles of silicosioxane and polycarbonate urethane polymer POSS-PCU, polystyrene block-isobutylene-block-styrene SIBS, PTFE polytetraﬂ uoroethylene, copolymers and composites based on oleﬁ n polymers series and polyesters, the idea of creating a material with a given three-dimensional microarchitecture that determines the anisotropy and the necessary mechanical properties.

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A mechanical heart valve is the best choice

Cited by 22 publications

References 22 publications

Polyisobutylene-Based Thermoplastic Elastomers for Manufacturing Polymeric Heart Valve Leaflets: In Vitro and In Vivo Results

Polyisobutylene-Based Thermoplastic Elastomers for Manufacturing Polymeric Heart Valve Leaflets: In Vitro and In Vivo Results

Continued use of Warfarin in lower dose has safe maternal and neonatal outcomes in pregnant women with Prosthetic Heart Valves

Polymeric Heart Valve Prostheses: Condition and Perspectives

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