A Mechanical Simulator of Cardiac Wall Kinematics

Cutrì, Elena; Bagnoli, Paola; Marcelli, Emanuela; Biondi, Federico; Cercenelli, Laura; Costantino, Maria Laura; Plicchi, Gianni; Fumero, R.

doi:10.1097/mat.0b013e3181d7db0c

Cited by 5 publications

(5 citation statements)

References 28 publications

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“…1 ). The two processes may not be affected in the same way by ventricular dysfunction [ 29 ], so their evaluation may represent a valuable tool for clinical practice, even in moderate pathological situations that are not detected by analysing classical hemodynamic parameters [ 17 , 26 , 30 – 32 ].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive assessment of left ventricular myocardial function by two-dimensional speckle-tracking echocardiography

Llabata

Torres

Romero

et al. 2018

Cardiovasc Ultrasound

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BackgroundLeft ventricular ejection fraction (LVEF) results from the combined action of longitudinal and circumferential contraction, radial thickening, and basal and apical rotation. The study of these parameters together may lead to an accurate assessment of the cardiac function.MethodsNinety healthy volunteers, categorized by gender and age (≤ 55 and > 55 years), were evaluated using two-dimensional speckle tracking echocardiography. Transversal views of the left ventricle (LV) were obtained to calculate circumferential strain and left ventricular twist, while three apical views were obtained to determine longitudinal strain (LS) and mitral annular plane systolic excursion (MAPSE). We established the integral myocardial function of the LV according to: 1. The Combined Deformation Parameter (CDP), which includes Deformation Product (DP) - Twist x LS (° x %) - and Deformation Index (DefI) -Twist / LS (° / %)-; and 2. the Torsion Index (TorI): Twist / MAPSE (° / cm).ResultsThe mean age of our patients was 50.3 ± 11.1 years. CDP did not vary with gender or age. The average DP was − 432 ± 172 ° x %, and the average DefI was − 0.96 ± 0.36 ° / %. DP provides information about myocardial function (normal, pseudonormal, depressed), and the DefI quotient indicates which component (s) is/are affected in cases of abnormality. TorI was higher in volunteers over 55 years (16.5 ± 15.2 vs 13.1 ± 5.0 °/cm, p = 0.003), but did not vary with gender.ConclusionsThe proposed parameters integrate values of twisting and longitudinal shortening. They allow a complete physiological assessment of cardiac systolic function, and could be used for the early detection and characterization of its alteration.

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Section: Discussionmentioning

confidence: 99%

Comprehensive assessment of left ventricular myocardial function by two-dimensional speckle-tracking echocardiography

Llabata

Torres

Romero

et al. 2018

Cardiovasc Ultrasound

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“…In this study, we reported preliminary in vitro evaluations of the new implantable CardioMon lead, tested using a mechanical simulator of cardiac rotational movements. Additional lab tests will be conducted using an upgraded mechanical simulator that we recently designed, which is capable of reproducing all three components of cardiac motion (longitudinal, radial, and rotational) combined into synchronous movements [24].…”

Section: Discussionmentioning

confidence: 99%

An Implantable Sensorized Lead for Continuous Monitoring of Cardiac Apex Rotation

Marcelli

Cercenelli

2018

Sensors

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Changes in the pattern or amplitude of cardiac rotation have been associated with important cardiovascular diseases, including Heart Failure (HF) which is one of the major health problems worldwide. Recent advances in echocardiographic techniques have allowed for non-invasive quantification of cardiac rotation; however, these examinations do not address the continuous monitoring of patient status. We have presented a newly developed implantable, transvenous lead with a tri-axis (3D) MEMS gyroscope incorporated near its tip to measure cardiac apex rotation in the three-dimensional space. We have named it CardioMon for its intended use for cardiac monitoring. If compared with currently proposed implantable systems for HF monitoring based on the use of pressure sensors that can have reliability issues, an implantable motion sensor like a gyroscope holds the premise for more reliable long term monitoring. The first prototypal assembly of the CardioMon lead has been tested to assess the reliability of the 3D gyroscope readings. In vitro results showed that the novel sensorized CardioMon lead was accurate and reliable in detecting angular velocities within the range of cardiac twisting velocities. Animal experiments will be planned to further evaluate the CardioMon lead in in vivo environments and to investigate possible endocardial implantation sites.

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“…Moreover, pathologies which affect the fibers architecture and cardiac geometry were proved to alter the cardiac torsion pattern. For these reasons, the cardiac torsion represents a sensitive index of ventricular performance [9], [10], [11], [12], [13]. The assessment of cardiac torsion as a sensitive clinical index has led to a substantial increase of the number of experimental and clinical studies aimed at quantifying this parameter.…”

Section: Introductionmentioning

confidence: 99%

The cardiac torsion as a sensitive index of heart pathology: A model study

Cutrì

Serrani

Bagnoli

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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The torsional behaviour of the heart (i.e. the mutual rotation of the cardiac base and apex) was proved to be sensitive to alterations of some cardiovascular parameters, i.e. preload, afterload and contractility. Moreover, pathologies which affect the fibers architecture and cardiac geometry were proved to alter the cardiac torsion pattern. For these reasons, cardiac torsion represents a sensitive index of ventricular performance. The aim of this work is to provide further insight into physiological and pathological alterations of the cardiac torsion by means of computational analyses, combining a structural model of the two ventricles with simple lumped parameter models of both the systemic and the pulmonary circulations. Starting from diagnostic images, a 3D anatomy based geometry of the two ventricles was reconstructed. The myocytes orientation in the ventricles was assigned according to literature data and the myocardium was modelled as an anisotropic hyperelastic material. Both the active and the passive phases of the cardiac cycle were modelled, and different clinical conditions were simulated. The results in terms of alterations of the cardiac torsion in the presence of pathologies are in agreement with experimental literature data. The use of a computational approach allowed the investigation of the stresses and strains in the ventricular wall as well as of the global hemodynamic parameters in the presence of the considered pathologies. Furthermore, the model outcomes highlight how for specific pathological conditions, an altered torsional pattern of the ventricles can be present, encouraging the use of the ventricular torsion in the clinical practice.

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A Mechanical Simulator of Cardiac Wall Kinematics

Cited by 5 publications

References 28 publications

Comprehensive assessment of left ventricular myocardial function by two-dimensional speckle-tracking echocardiography

Comprehensive assessment of left ventricular myocardial function by two-dimensional speckle-tracking echocardiography

An Implantable Sensorized Lead for Continuous Monitoring of Cardiac Apex Rotation

The cardiac torsion as a sensitive index of heart pathology: A model study

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