A mechanically robust and stable estradiol-loaded PHEMA-based hydrogel barrier for intrauterine adhesion treatment

Xie, Xiangyan; Xu, Ran; Ouyang, Hongyan; Tan, Shiqiao; Guo, Chuan; Luo, Xingqi; Xie, Yuanjie; Wu, Di; Dong, Xiangyu; Wu, Jinrong; Wang, Yi; Zhao, Lijuan

doi:10.1039/d2tb01740g

Cited by 16 publications

(12 citation statements)

References 36 publications

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“…The mesoporous silica also endowed the composite hydrogel with superior mechanical properties, more excellent stability, and good biocompatibility similar to that of the pure hydrogel, allowing it to maintain its structure and mechanical properties in simulated uterine fluid for 30 days. In addition, the hydrogel consistently and steadily released loaded drug, showing a good therapeutic effect in promoting endometrial cell proliferation and inhibiting fibrosis progression [ 108 ] ( Figure 3 ).…”

Section: Application Of Mesoporous Material-loaded Composite Hydrogelsmentioning

confidence: 99%

“…( f ) Stress–strain curves and ( g ) elastic moduli–fracture toughness histogram of the PHMH-Si hydrogel soaked in simulated uterine fluid for 30 days. ( h ) Mechanical properties of the PHMH-Si hydrogel in the as-prepared state ( ) and after swelling in the simulated uterine fluid for 30 days ( ), and other as-prepared PHEMA-based hydrogels [ 108 ].…”

Section: Figurementioning

confidence: 99%

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Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

Chen

Qiu

Xia

et al. 2023

Gels

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Scientists have been attempting to improve the properties of mesoporous materials and expand their application since the 1990s, and the combination with hydrogels, macromolecular biological materials, is one of the research focuses currently. Uniform mesoporous structure, high specific surface area, good biocompatibility, and biodegradability make the combined use of mesoporous materials more suitable for the sustained release of loaded drugs than single hydrogels. As a joint result, they can achieve tumor targeting, tumor environment stimulation responsiveness, and multiple therapeutic platforms such as photothermal therapy and photodynamic therapy. Due to the photothermal conversion ability, mesoporous materials can significantly improve the antibacterial ability of hydrogels and offer a novel photocatalytic antibacterial mode. In bone repair systems, mesoporous materials remarkably strengthen the mineralization and mechanical properties of hydrogels, aside from being used as drug carriers to load and release various bioactivators to promote osteogenesis. In hemostasis, mesoporous materials greatly elevate the water absorption rate of hydrogels, enhance the mechanical strength of the blood clot, and dramatically shorten the bleeding time. As for wound healing and tissue regeneration, incorporating mesoporous materials can be promising for enhancing vessel formation and cell proliferation of hydrogels. In this paper, we introduce the classification and preparation methods of mesoporous material-loaded composite hydrogels and highlight the applications of composite hydrogels in drug delivery, tumor therapy, antibacterial treatment, osteogenesis, hemostasis, and wound healing. We also summarize the latest research progress and point out future research directions. After searching, no research reporting these contents was found.

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Section: Application Of Mesoporous Material-loaded Composite Hydrogelsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

Chen

Qiu

Xia

et al. 2023

Gels

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“…276 Other biomedical materials include PEO-sodium carboxymethylcellulose gel, 363 and poly (hydroxyethyl methacrylate) (PHEMA) hydrogel. 274 With the continuous development of materials science and preparation technology, hydrogels in tissue engineering are gradually evolving toward stimulus-responsive smart hydrogels. Stimulus-responsive smart hydrogels are a class of smart polymeric materials that undergo deformation and phase change in the gel network in response to stimuli from the surrounding environment, which in turn causes swelling-shrinkage or gel-sol transition, [364][365][366] often manifested as changes in solubility and changes in drug release rate.…”

Section: 14mentioning

confidence: 99%

“…It also increased the expression of Ki‐67, CK7, CK19, VEGF, and ER/PR and inhibited the fibrotic process 276 . Other biomedical materials include PEO–sodium carboxymethylcellulose gel, 363 and poly (hydroxyethyl methacrylate) (PHEMA) hydrogel 274 …”

Section: The Future Of Regenerative Medicine In Cyclical Endometrial ...mentioning

confidence: 99%

Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions

Hu,

Wu,

Yong

et al. 2023

MedComm

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The endometrium is a unique human tissue with an extraordinary ability to undergo a hormone‐regulated cycle encompassing shedding, bleeding, scarless repair, and regeneration throughout the female reproductive cycle. The cyclical repair and regeneration of the endometrium manifest as changes in endometrial epithelialization, glandular regeneration, and vascularization. The mechanisms encompass inflammation, coagulation, and fibrinolytic system balance. However, specific conditions such as endometriosis or TCRA treatment can disrupt the process of cyclical endometrial repair and regeneration. There is uncertainty about traditional clinical treatments' efficacy and side effects, and finding new therapeutic interventions is essential. Researchers have made substantial progress in the perspective of regenerative medicine toward maintaining cyclical endometrial repair and regeneration in recent years. Such progress encompasses the integration of biomaterials, tissue‐engineered scaffolds, stem cell therapies, and 3D printing. This review analyzes the mechanisms, diseases, and interventions associated with cyclical endometrial repair and regeneration. The review discusses the advantages and disadvantages of the regenerative interventions currently employed in clinical practice. Additionally, it highlights the significant advantages of regenerative medicine in this domain. Finally, we review stem cells and biologics among the available interventions in regenerative medicine, providing insights into future therapeutic strategies.

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“…33,34 In recent years, the preparation of hydrogel-type electromagnetic shielding materials has required the incorporation of relevant functional fillers to endow them with electrical conductivity and electromagnetic shielding capabilities. 35,36 Among carbon nanomaterials, graphene and carbon nanotubes, including their components and composites, are the materials of choice for electromagnetic shielding due to their low density, high conductivity, and corrosion resistance. 37,38 Among them, carbon nanotubes are the most prevalent fillers due to their excellent aspect ratio, high modulus, high electrical conductivity, and mature preparation techniques.…”

Section: Introductionmentioning

confidence: 99%

Mechanical, robust and conductive eco-friendly self-assembling hydrogel: a novel material for electromagnetic shielding

Xu,

Pei,

Zhan

et al. 2023

New J. Chem.

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A mechanically robust and stable estradiol-loaded PHEMA-based hydrogel barrier for intrauterine adhesion treatment

Abstract: Estrogen combined with physical barrier therapy may be a prospective method to repair damaged endometrium and prevent postsurgical re-adhesion in the treatment of intrauterine adhesions (IUAs), but there lacks a...

Cited by 16 publications

References 36 publications

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions

Mechanical, robust and conductive eco-friendly self-assembling hydrogel: a novel material for electromagnetic shielding

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