A mechanistic and empirical review of antcins, a new class of phytosterols of formosan fungi origin

Kumar, K. J. Senthil; Vani, M. Gokila; Chen, Chieh-Yin; Hsiao, Wen-Wei; Li, Jing; Zhifang, Lin; Chu, Fang-Hua; Yen, Gow‐Chin; Wang, Sheng-Yang

doi:10.1016/j.jfda.2019.09.001

Cited by 27 publications

(12 citation statements)

References 129 publications

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“…More than 160 compounds have been extracted from the rare Taiwenese fungus named Antrodia Camphorata (or Antrodia cinnamomea or Taiwanofungus camphoratus ) and studied for their various potential biological activities including anti-cancer, anti-oxidant, anti-inflammatory, anti-diabetic, anti-microbial, anti-ageing, hepatoprotective, neuroprotective, anti-hypertensive, anti-hyperlipidemic, and immunomodulatory properties ( Lu et al., 2013 ; Senthil Kumar et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Antroquinonol administration in animal preclinical studies for Alzheimer's disease (AD): A new avenue for modifying progression of AD pathophysiology

Fernández

Aust

Lye

et al. 2022

Brain, Behavior, & Immunity - Health

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Section: Introductionmentioning

confidence: 99%

Antroquinonol administration in animal preclinical studies for Alzheimer's disease (AD): A new avenue for modifying progression of AD pathophysiology

Fernández

Aust

Lye

et al. 2022

Brain, Behavior, & Immunity - Health

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“…Antcins are the typical triterpenoid compounds of AC fruiting bodies. Among them, antcins B, C, H, and K possess anti-inflammatory, anticancer, and hepatoprotective activities [ 2 , 3 , 23 ]. The concentration of triterpenoids in AC fruiting bodies was approximately 2.3 times higher than in mycelia [ 24 ], and ergostane-type triterpenoids were only found in AC fruiting bodies [ 3 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Chemical Composition and Chronic Toxicity of Disc-Cultured Antrodia cinnamomea Fruiting Bodies

Liu

Hsu

et al. 2022

Toxics

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Antrodia cinnamomea (AC) is a popular fungus for use as folk medicine in health maintenance and disease prevention and treatment. Disc culture is a novel technique for producing AC fruiting bodies. This study aimed to investigate the bioactive components and toxicological properties of disc-cultured AC fruiting body powders (ACP) in rats. The HPLC technique was used to quantify the composition of bioactive triterpenoids in ACP. Toxicological properties were evaluated on male and female Sprague-Dawley rats receiving ACP orally at 200, 600, and 1000 mg/kg body weight for 90 days; the control group received only distilled water. The results show that ACP contained seven important AC index compounds, namely antcins A, B, C, K, and H, dehydrosulphurenic acid, and dehydroeburicoic acid. At the tested doses, oral ACP administration for 90 days caused no mortality, adverse effects on general health, body and organ weights, and food intake. Furthermore, no significant variations were observed in hematological and biochemical parameters among either sex of ACP-treated and control animals. An histopathological examination of vital organs showed no significant structural changes in organs, even in high-dose ACP-treated animals. This study indicated that ACP contained the major bioactive triterpenoids of AC fruiting bodies, and its no-observed-adverse-effect level (NOAEL) was 1000 mg/kg/day, about 20 times the recommended daily intake.

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“…Antrodia camphorata is an edible and precious mushroom endemic to Taiwan, which has been used as traditional medicine. A. camphorata has been found to exhibit a broad range of pharmacological effects, which include anti-microbial, anti-oxidative, anti-inflammatory, anti-diabetic, anti-aging, anticarcinogenic, neuroprotective, hepatoprotective, cardioprotective, and immunomodulatory effects [12][13][14][15]. Phytochemical investigation of A. camphorata led to the isolation and characterization of diverse bioactive phytochemicals that include benzenoids, ubiquinones, maleic anhydride and maleimide derivatives, terpenoids, and steroids [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Constituents of Antrodia camphorata on RAW 264.7 Cells Induced by Polyinosinic-Polycytidylic Acid

Jiang

Lin

et al. 2022

Molecules

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Antrodia camphorata is an endemic mushroom in Taiwan. This study was designed to screen anti-inflammatory compounds from the methanolic extract of the mycelium of A. camphorata on nitric oxide (NO) production in RAW 264.7 cells induced by polyinosinic-polycytidylic acid (poly I:C), a synthetic analog of double-stranded RNA (dsRNA) known to be present in viral infection. A combination of bioactivity-guided isolation with an NMR-based identification led to the isolation of 4-acetylantroquinonol B (1), along with seven compounds. The structure of new compounds (4 and 5) was elucidated by spectroscopic experiments, including MS, IR, and NMR analysis. The anti-inflammatory activity of all isolated compounds was assessed at non-cytotoxic concentrations. 4-Acetylantroquinonol B (1) was the most potent compound against poly I:C-induced NO production in RAW 264.7 cells with an IC50 value of 0.57 ± 0.06 μM.

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A mechanistic and empirical review of antcins, a new class of phytosterols of formosan fungi origin

Cited by 27 publications

References 129 publications

Antroquinonol administration in animal preclinical studies for Alzheimer's disease (AD): A new avenue for modifying progression of AD pathophysiology

Antroquinonol administration in animal preclinical studies for Alzheimer's disease (AD): A new avenue for modifying progression of AD pathophysiology

Chemical Composition and Chronic Toxicity of Disc-Cultured Antrodia cinnamomea Fruiting Bodies

Anti-Inflammatory Constituents of Antrodia camphorata on RAW 264.7 Cells Induced by Polyinosinic-Polycytidylic Acid

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